Evaluation of left ventricular longitudinal function and synchrony after dual chamber pacemaker implantation

Baronaitė-Dūdonienė, Kristina; Vaškelytė, Jolanta Justina; Puodžiūkynas, Aras; Zabiela, Vytautas; Kazakevičius, Tomas; Šakalytė, Gintarė

doi:10.1016/j.medici.2014.11.010

Cited by 4 publications

(1 citation statement)

References 16 publications

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“…PICM is mainly seen in patients with a single chamber pacemaker on the right ventricle. However, a dual-chamber pacemaker could also play a dyssynchrony role [20]. In RV pacing, lead placement on both apical and septal is related to dyssynchrony, although the incidence of dyssynchrony is lower in the septal location [21].…”

Section: Discussionmentioning

confidence: 99%

Mechanism of Pacemaker-Induced Left Ventricular Dysfunction: Study Protocol

Laksono¹,

Yuniadi²,

Soesanto³

et al. 2022

Journal of Hunan University Natural Sciences

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A permanent pacemaker (PPM) is currently the definitive treatment for patients with a total atrioventricular block (TAVB). The number of pacemaker implantation has been increasing every year. However, PPM implantation increases the risk of developing left ventricular (LV) dysfunction and becoming pacemaker-induced cardiomyopathy (PICM). There has never been a published study on the cellular mechanism of LV dysfunction caused by PPM implantation. The mechanism of pacemaker-induced left ventricular dysfunction (PILVD) study is a multi-center, quasi-experimental, etiognostic study with a time-series design. This etiognostic study aims to investigate the mechanism of cellular level changes in TAVB patients who had PPM implanted. In particular, the difference in serum miR-155 levels and plasma levels of IL-6, sTNFR-2, MMP-9, N-Cad, and ZO-1 in TAVB patients had LV dysfunction caused by right ventricular dysfunction septal PPM implantation measured by global longitudinal strain (GLS) obtained from echocardiography. Blood samples and echocardiographic examinations will be performed on patients who satisfied the inclusion criteria prior to pacemaker implantation, one month after, and three months following pacemaker implantation. The ELISA method will be used to assess IL-6, sTNFR-2, MMP-9, ZO-1, and N-Cad from plasma samples. MiR-155 levels in serum will be determined using the reverse-transcriptase polymerase chain reaction (RT-PCR) technique. The main findings are a decrease in serum miR-155 levels and increased plasma IL-6, sTNFR-2, MMP-9, N-Cad, and ZO-1 levels in TAVB patients who developed LV dysfunction due to right ventricular septal pacemaker implantation measured by GLS at 1 and 3 months.

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Section: Discussionmentioning

confidence: 99%

Mechanism of Pacemaker-Induced Left Ventricular Dysfunction: Study Protocol

Laksono¹,

Yuniadi²,

Soesanto³

et al. 2022

Journal of Hunan University Natural Sciences

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Impact of right ventricular lead position on left ventricular functions and early remodeling in permanent single- and dual-chamber pacemakers

Ali

Hawas

Ramadan

et al. 2022

Herzschr Elektrophys

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Assessment of Left Ventricular Asynchrony after Permanent Cardiac Pacing by Using Speckle Tracking Echocardiography

Teima¹,

Mahfouz

Maaty³

et al. 2019

The Medical Journal of Cairo University

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Background: Echocardiography is important in assessing Left Ventricular (LV) Mechanical Dysynchrony (LVMD) and left ventricular function after permanent pacemaker. At present, Real-Time Three Dimensional Echocardiography (RT3DE) and tissue Doppler imaging (TDI) are the most sensitive and commonly used techniques for the quantification of LVMD. Global longitudinal strain (GLS) and LV dyssynchrony assessment enables us to detect early signs of LV dysfunction after cardiac pacing. Aim of Study:To evaluate LV mechanical dyssynchrony and LV function in different pacing modes after permanent cardiac pacing by using TDI and speckle tracking echocardiography and to correlate these changes with other clinical, electrocardiographic and echocardiographic data.

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Evaluation of left ventricular longitudinal function and synchrony after dual chamber pacemaker implantation

Abstract: Global longitudinal strain and LV dyssynchrony assessment enables us to detect early signs of LV dysfunction. Mechanisms of dyssynchrony development will be useful for pacemaker programing choices in order to prevent further dyssynchronisation.

Cited by 4 publications

References 16 publications

Mechanism of Pacemaker-Induced Left Ventricular Dysfunction: Study Protocol

Mechanism of Pacemaker-Induced Left Ventricular Dysfunction: Study Protocol

Impact of right ventricular lead position on left ventricular functions and early remodeling in permanent single- and dual-chamber pacemakers

Assessment of Left Ventricular Asynchrony after Permanent Cardiac Pacing by Using Speckle Tracking Echocardiography

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