Evaluation of left ventricular endocardial volumes and ejection fractions computed from gated perfusion SPECT with magnetic resonance imaging: Comparison of two methods

Faber, Tracy L.; Vansant, John; Pettigrew, Roderic I.; Galt, James R.; Blais, Michel; Chatzimavroudis, George P.; Cooke, C. David; Folks, Russell; Waldrop, Sandra M.; Gürtler-Krawczyńska, E; Wittry, Mark D.; Garcia, Ernest

doi:10.1067/mnc.2001.117173

Cited by 79 publications

(65 citation statements)

References 10 publications

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“…Subsequent studies compared the QGS results with other reference techniques, such as equilibrium radionuclide angiocardiography (ERNA), echocardiography, contrast ventriculography and magnetic resonance imaging [16, 19-21, 23, 26-36, 55]. The Emory Cardiac Toolbox (ECTb, Emory University, Atlanta, GA) has also been extensively validated by comparison with first-pass radionuclide ventriculography, ERNA, echocardiography and magnetic resonance imaging [23,25,30,34,55]. Furthermore, comparative studies with ERNA and magnetic resonance imaging have confirmed the reliability of 4D-MSPECT (University of Michigan Medical Center, Ann Arbor, MI) [32,34,55,56].…”

Section: Value Of Gated Spect For Estimating Left Ventricular Functionmentioning

confidence: 99%

The expanding role of left ventricular functional assessment using gated myocardial perfusion SPECT: the supporting actor is stealing the scene

Sciagrà

2007

Eur J Nucl Med Mol Imaging

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Background Gating of single-photon emission computed tomography (SPECT) has significantly improved the reliability and diagnostic accuracy of myocardial perfusion imaging. The functional parameters derived from this technique, mainly left ventricular volumes and ejection fraction, have been demonstrated to be accurate and reproducible. They are able to increase the detection of severe and extensive coronary artery disease and show a significant incremental prognostic power over perfusion abnormalities. Therefore, the importance given to gated SPECT functional data has progressively grown. Discussion This circumstance has further expanded the indications for myocardial perfusion imaging and strengthened its position among the different imaging modalities. Moreover, several studies show that the evaluation of ventricular function may have a leading part in justifying the execution of perfusion scintigraphy in various clinical conditions. Aim Aim of this review is to describe this evolution of gated SPECT functional assessment from a supporting rank with respect to perfusion, to a main actor position in the field of cardiac imaging.

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Section: Value Of Gated Spect For Estimating Left Ventricular Functionmentioning

confidence: 99%

The expanding role of left ventricular functional assessment using gated myocardial perfusion SPECT: the supporting actor is stealing the scene

Sciagrà

2007

Eur J Nucl Med Mol Imaging

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“…Various modalities, including quantitative echocardiography (ECHO), semiquantitative ECHO, radionuclide ventriculography (RNA), methoxyisobutyl isonitrile scanning, angiography, computed tomography (CT), positron emission tomography and magnetic resonance imaging (MRI), exist for estimating LVEF (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). In clinical practice, ECHO is often used as the first-line test for screening patients for decreased LVEF (17).…”

mentioning

confidence: 99%

Limitations in the current screening practice of assessing left ventricular ejection fraction for a primary prophylactic implantable defibrillator in southern Ontario

Lane

Dorian

Ghosh

et al. 2010

Canadian Journal of Cardiology

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“…In which quantitative assessment of end-diastolic and end-systolic perfusion, wall motion and wall thickening using the 20-segment bull's eye representation of the QGS model [ figure 2], as well as estimates for end-diastolic (EDV) and end-systolic (ESV) ventricular volume and derived stroke volume and LVEF is incorporated. The underlying algorithms have been reviewed in literature [2][3][4][5][6][7][8][9][10][11][12][13]17]. The software algorithm implementation is the same in the different camera systems.…”

Section: Gated Spect Protocolmentioning

confidence: 99%

“…With regard to the validation of the Cedars-Sinai's Quantitative SPECT (QGS) software, several requirements have already been met. The algorithm and its basic validation have already been described [2][3][4][5][6][7][8][9][10][11][12][13][14][15]. However, one particular issue is still not fully solved: reproducibility of the quantitative assessment of regional functional parameters in the presence of severe major defects or artifacts.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Quantitative Gated SPECT (QGS) software program in the presence of large perfusion defects

America

Bax

Dibbets‐Schneider

et al. 2005

Int J Cardiovasc Imaging

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Objectives: To evaluate the reproducibility and operator dependence for the quantitative regional left ventricular functional parameters (LVFP) assessed by Cedars-Sinai's Quantitative automated gated SPECT (QGS) software. Methods: The QGS algorithm was reviewed in detail and potential operator dependencies were defined. Series of prototypes were selected, consisting of a) normal perfusion, b) perfusion defects in all perfusion regions, c) perfusion studies of patients with angiographic confirmed normal coronary arteries, proximal ( >70% stenoses) single and multiple vessel disease, and d) spurious activity in close proximity. While defining and re-orienting the volume containing the left ventricle, the operator adjusted 8 variables/ degrees of freedom (DF). The software was used without further operator interventions. Results were expressed as a coefficient of variation (COV). Separate COV were calculated per distinct DF. A segment was considered not robust when the COV did exceed 20% in a single DF, 15% in at least 2 DF, or 10% in at least 3 DF. Results: Regional left ventricular EF and volumes showed excellent reproducibility. Normal perfusion and the vessel disease prototypes showed an excellent COV (for all re-orientation steps [33/prototype]) mostly below 5% for LVFP. However, regional wall motion and thickening became less reliable in the presence of large perfusion defects or artifacts. Conclusions: Quantitative estimates for regional left ventricular functional data show excellent reproducibility using automated gated SPECT. However, there may be substantial operator dependency in the presence of large defects or spurious activity in close proximity.

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Evaluation of left ventricular endocardial volumes and ejection fractions computed from gated perfusion SPECT with magnetic resonance imaging: Comparison of two methods

Cited by 79 publications

References 10 publications

The expanding role of left ventricular functional assessment using gated myocardial perfusion SPECT: the supporting actor is stealing the scene

The expanding role of left ventricular functional assessment using gated myocardial perfusion SPECT: the supporting actor is stealing the scene

Limitations in the current screening practice of assessing left ventricular ejection fraction for a primary prophylactic implantable defibrillator in southern Ontario

Evaluation of the Quantitative Gated SPECT (QGS) software program in the presence of large perfusion defects

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