Evaluation of left atrial mechanical functions and atrial conduction abnormalities in patients with clinical hypothyroid

Öztürk, Serkan; Dikbaş, Oğuz; Özyaşar, Mehmet; Ayhan, Suzi Selim; Özlü, Fatih; Baltaci, Davut; Erdem, Alim; Alçelik, Aytekin; Tosun, Mehmet; Yazıcı, Mehmet

doi:10.5603/cj.2012.0051

Cited by 16 publications

(24 citation statements)

References 29 publications

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“…The present study shows that LA conduit and reservoir functions are decreased, whereas LA booster pump is increased in the SHT patients comparing with the healthy controls, which agrees with Ozturk et al 13,14 Interestingly, our results show that levothyroxine therapy firstly started to improve LA conduit and reservoir function, while LA pump function obviously needed more time. However, 1-year substitution therapy did not induce complete restoration of LA function in the SHT patients.…”

Section: Discussionsupporting

confidence: 94%

“…This also concurs with other studies. 13,14 Our results about LA mechanics in the SHT subjects show that LA systolic strain and strain rates significantly and progressively decreased from the controls, throughout the treated SHT patients, to the untreated SHT subjects. LA early diastolic strain rate was lower, and late diastolic strain rate was higher, in the SHT par- ticipants at the baseline.…”

Section: Discussionmentioning

confidence: 87%

“…Previous investigations had shown a correlation between increased LA minimum volume and left ventricular diastolic dysfunction, 23 which could be one of the reasons for left ventricular diastolic dysfunction in the SHT patients, which was also confirmed in this study by significantly increased mitral E/e′ ratio, as well as deteriorated LV early and late diastolic strain rates, in the SHT patients before levothyroxine therapy. Ozturk et al 13,14 did not find a statistically important difference in LA maximum, minimum, or pre-A volumes between hypothyroid patients and the controls.…”

Section: Discussionmentioning

confidence: 94%

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Left Atrial Phasic Function and Mechanics in Women with Subclinical Hypothyroidism: The Effects of Levothyroxine Therapy

et al. 2014

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 94%

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Left Atrial Phasic Function and Mechanics in Women with Subclinical Hypothyroidism: The Effects of Levothyroxine Therapy

et al. 2014

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“…Öztürk et al (26) found prolonged intra- and inter-atrial EMCD in patients with overt hypothyroidism in their study. As a consequence, prolonged intra- and inter-atrial EMCD may be associated with an increased risk of arrhythmias in patients with overt hypothyroidism.…”

Section: Discussionmentioning

confidence: 66%

Evaluating functional capacity, and mortality effects in the presence of atrial electromechanical conduction delay in patients with systolic heart failure

Bi̇lgi̇n

Yıldız²,

Tülüce³

et al. 2015

Anatol J Cardiol

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Objective:Atrial functions are relatively suppressed in heart failure (HF). We aimed to investigate the associations of intra- and inter-atrial electromechanical conduction delay (EMCD) with functional class and mortality over a 12-month follow-up period.Methods:The prospective study included 65 patients with systolic HF and 65 healthy subjects with normal sinus rhythm. Left ventricular (LV) systolic functions and left atrial (LA) dimensions and volumes were evaluated by transthoracic echocardiography. Tissue Doppler imaging (TDI) signals at the lateral border of the mitral annulus (lateral PA’), septal mitral annulus (septal PA’), and tricuspid annulus (tricuspid PA’) were measured. Intra- and inter-atrial EMCD were calculated.Results:Mitral inflow velocities were studied using pulsed-wave Doppler after placing the sample volume at the leaflets’ tips. The peak early (E wave) and late (A wave) velocities were measured. The septal annular E/E’ ratio was relatively higher and lateral, septal, and right ventricular S, E’, and A’ waves were significantly lower in the HF group than in the control group (12.49±6.03 – 7.16±1.75, pE/E’ <0.0001). Intra-atrial EMCD was detected as 117.5 ms and inter-atrial EMCD as 127.5 ms in patients with prolonged atrial EMCD. A significant increase was found in prolonged intra- and inter-atrial EMCD according to functional capacity increase (p=0.012 and p=0.031, respectively). The incidence of mortality was significantly higher in patients with prolonged atrial EMCD (p=0.025), and 5 patients in the HF group died during the study over the 12-month follow-up period.Conclusions:In this study, we found a relationship between prolonged atrial conduction time and increased functional class and mortality in patients with systolic HF. (Anatol J Cardiol 2016; 16: 579-86)

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“…Recently, it has been shown that paroxysmal AF, rheumatoid arthritis, systemic lupus erythematosus and subclinical hypothyroidism may impair LA functions and atrial conduction times [14,15,16,17]. However, to date, effects of a single HD session and acute volume-preload changes on atrial electromechanical conduction functions have not been investigated by TDE.…”

Section: Introductionmentioning

confidence: 99%

The Effects of a Single Dialysis Session on Atrial Electromechanical Conduction Times and Functions

Tekçe¹,

Öztürk²,

Aktas³

et al. 2013

Kidney Blood Press Res

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Background/Aims: Abnormalities in atrial electromechanical delay (EMD) times and mechanical functions are considered as independent predictors of atrial fibrillation. However, to date, effects of a single hemodialysis (HD) session and acute volume-preload changes on atrial-EMD functions have not been investigated by Tissue Doppler Echocardiography (TDE). The aim of the present study was to evaluate atrial-EMD times and mechanical functions in HD patients. Methods: Thirty-five non-diabetic, normotensive HD patients and 35 healthy control subjects were enrolled in the study. Standard and TDE performed before mid-week dialysis session for hemodialysis group and on admission for control group. Results: Interatrial and left-right intraatrial-EMD intervals and left atrial mechanical volumes were significantly longer in hemodialysis group compared to controls (all p<0.01) and were reduced after HD session. Furthermore, removed ultrafiltration volume was associated with reduction in atrial-EMD intervals and functional volumes. LA-passive emptying volume, ultrafiltration volume, LV-E/E' ratio, and V_p were independent predictors of interatrial-EMD. Conclusions: The present study confirms negative effects in HD patients of structural remodeling and reveals negative effects of electrical remodeling. Prolonged inter and intraatrial-EMD intervals should be the underlying pathophysiological factors of increased rate of atrial fibrillation in the HD population.

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Evaluation of left atrial mechanical functions and atrial conduction abnormalities in patients with clinical hypothyroid

Cited by 16 publications

References 29 publications

Left Atrial Phasic Function and Mechanics in Women with Subclinical Hypothyroidism: The Effects of Levothyroxine Therapy

Left Atrial Phasic Function and Mechanics in Women with Subclinical Hypothyroidism: The Effects of Levothyroxine Therapy

Evaluating functional capacity, and mortality effects in the presence of atrial electromechanical conduction delay in patients with systolic heart failure

The Effects of a Single Dialysis Session on Atrial Electromechanical Conduction Times and Functions

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