Evaluation of left atrial longitudinal function in patients with hypertrophic cardiomyopathy: a tissue Doppler imaging and two-dimensional strain study

Paraskevaidis, Ioannis; Panou, Fotis; Papadopoulos, Costas; Farmakis, Dimitrios; Parissis, John; Ikonomidis, Ignatios; Rigopoulos, Angelos; Iliodromitis, Efstathios K.; Kremastinos, Dimitrios Th.

doi:10.1136/hrt.2008.146548

Cited by 91 publications

(72 citation statements)

References 49 publications

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“…21 One study in 50 HCM patients indicated that LA reservoir speckle tracking-derived strain independently predicts occurrence of AF requiring hospitalization (odds ratio, 0.85; 95% . 24 The present study, representing the largest cohort of HCM patients evaluated by LA strain to date, demonstrates higher sensitivity of LA strain compared with LA diameter to predict new-onset AF and confirms its independent predictive value for this end point.…”

Section: Discussionmentioning

confidence: 57%

Left Atrial Size and Function in Hypertrophic Cardiomyopathy Patients and Risk of New-Onset Atrial Fibrillation

Debonnaire

Joyce

Hiemstra

et al. 2017

Circ: Arrhythmia and Electrophysiology

132

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Background— The value of left atrial (LA) diameter, volume, and strain to risk stratify hypertrophic cardiomyopathy patients for new-onset atrial fibrillation (AF) was explored. Methods and Results— A total of 242 hypertrophic cardiomyopathy patients without AF history were evaluated by (speckle-tracking) echocardiography. During mean follow-up of 4.8±3.7 years, 41 patients (17%) developed new-onset AF. Multivariable analysis showed LA volume (≥37 mL/m 2 ; hazard ratio, 2.68; 95% confidence interval, 1.30–5.54; P =0.008) and LA strain (≤23.4%; hazard ratio, 3.22; 95% confidence interval, 1.50–6.88; P =0.003), but not LA diameter (≥45 mm; hazard ratio, 1.67; 95% confidence interval, 0.84–3.32; P =0.145), as independent AF correlates. Importantly, 59% (n=24) of AF events occurred despite a baseline LA diameter <45 mm, observed in 185 patients. In this patient subset, LA strain (area under the curve 0.73) and LA volume (area under the curve 0.83) showed good predictive value for new-onset AF. Furthermore, patients with LA volume <37 versus ≥37 mL/m 2 and LA strain >23.4% versus ≤23.4% had superior 5-year AF-free survival of 93% versus 80% ( P =0.003) and 98% versus 74% ( P =0.002), respectively. Importantly, LA volume <37 mL/m 2 and strain >23.4% yielded high negative predictive value (93% and 98%, respectively) for new-onset AF. Likelihood ratio test indicated incremental value of LA volume assessment ( P =0.011) on top of LA diameter to predict new-onset AF in hypertrophic cardiomyopathy patients with LA diameter <45 mm, which tended to increase further by addition of LA strain ( P =0.126). Conclusions— LA diameter, volume, and strain all relate to new-onset AF in hypertrophic cardiomyopathy patients. In patients with normal LA size, however, both LA volume and strain further refine risk stratification for new-onset AF.

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Section: Discussionmentioning

confidence: 57%

Left Atrial Size and Function in Hypertrophic Cardiomyopathy Patients and Risk of New-Onset Atrial Fibrillation

Debonnaire

Joyce

Hiemstra

et al. 2017

Circ: Arrhythmia and Electrophysiology

132

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“…'Strain' görüntüleme SA fonksiyonlarının değerlendirilme-sinde de oldukça değerlidir. Doku Doppler ve iki boyutlu "strain" ile yapılmış incelemelerde atrium fonksiyonlarının HKM hastalarında diğer ikincil nedenlerle ilişkili hipertrofi hastalarına göre daha fazla azaldığı gösteril-miştir (32). "Strain" ekokardiyografinin HKM'li hastalarda prognozun belirlemesindeki yeri şu an için net olarak bilinmemektedir.…”

Section: Strain (Gerilme) Görüntülemeunclassified

Hipertrofik kardiyomiyopatili hastaların risk sınıflandırmasında görüntüleme yöntemlerinin yeri

Tülüce¹,

Emren²,

Tülüce³

et al. 2015

Ege Tıp Dergisi

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Hipertrofik kardiyomiyopati (HKM) genetik geçişli bir kalp hastalığıdır. Genç sporcularda ani kardiyak ölümün (AKÖ) en sık nedenidir. Bu ölümlerin önlenebilmesi için hekimler büyük özen göstermektedir. Ani kardiyak ölüm açısından yüksek riskli hastalar implante edilebilen kardiyoverter defibrilatör tedavisi için adaydırlar. Ani kardiyak ölüm açısından yüksek riskli bu bireylerin saptanabilmesi için yapılan risk sınıflandırmasında kardiyak görüntüleme yöntemleri önemli bilgiler sağlamaktadır. Görüntüleme yöntemleri ile elde edilen bilgilerin doğru yorumlanması ve önlemlerin alınması bu hastalar için hayat kurtarıcı olması nedeniyle büyük önem taşımaktadır. Teknolojideki gelişmeler yüksek riskli hastaların erken tespitine önemli katkılar sağlamaktadır. Bu derlemede biz HKM'li hastaların risk sınıflandırmasında görüntüleme yöntemlerinin yeri ve önemini değerlendirdik.Anahtar Sözcükler: Hipertrofik kardiyomiyopati, ani kardiyak ölüm, kalp görüntüleme yöntemleri. Abstract Hypertrophic cardiomyopathy (HCM) is a genetic cardiac disorder. It is the most common reason of sudden cardiac death (SCD) in young athletes. Prevention of these deaths is

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“…U pacjentów z HCM podłużne odkształcenie ścian LA jest wyraźnie obniżone, zarówno w fazach biernych (rezerwuarowej i okresie wczesnorozkurczowym), jak i czynnej (skurcz LA). Zmiany te są bardziej zaawansowane niż u chorych z wtórną przebudową LA, co może wskazywać na pierwotny remodeling jego ściany [78].…”

Section: Powiększenie Lewego Przedsionkaunclassified

Imaging in hypertrophic cardiomyopathy. Expert consensus statement of the Polish Clinical Forum for Cardiovascular Imaging

Oko−Sarnowska

Pyda²,

Trojnarska³

et al. 2015

Kardiol Pol

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Evaluation of left atrial longitudinal function in patients with hypertrophic cardiomyopathy: a tissue Doppler imaging and two-dimensional strain study

Abstract: Left atrial longitudinal function is reduced in HCM compared to non-HCM LVH and healthy controls. In addition, 2D atrial strain has an additive value in differentiating HCM from non-HCM LVH and it is more reproducible and less time consuming than TDI strain.

Cited by 91 publications

References 49 publications

Left Atrial Size and Function in Hypertrophic Cardiomyopathy Patients and Risk of New-Onset Atrial Fibrillation

Left Atrial Size and Function in Hypertrophic Cardiomyopathy Patients and Risk of New-Onset Atrial Fibrillation

Hipertrofik kardiyomiyopatili hastaların risk sınıflandırmasında görüntüleme yöntemlerinin yeri

Imaging in hypertrophic cardiomyopathy. Expert consensus statement of the Polish Clinical Forum for Cardiovascular Imaging

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