Evaluation of Leaf extracts of <i>Simarouba glauca</i> on Experimentally Induced Inflammatory Bowel Diseases in Wistar rats

Ariharasivakumar, Ganesan; Karthikaa, T.; Nongkhlaw, Ridahunlang; Packialakshmi, P.

doi:10.5958/0974-360x.2020.00340.6

Rese. Jour. of Pharm. and Technol.

2020

DOI: 10.5958/0974-360x.2020.00340.6

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Evaluation of Leaf extracts of Simarouba glauca on Experimentally Induced Inflammatory Bowel Diseases in Wistar rats

Ganesan Ariharasivakumar¹,

T. Karthikaa²,

Ridahunlang Nongkhlaw³

et al.

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2023

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Cited by 2 publications

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Gallic acid attenuates the Chronic construction injury of sciatic nerve induced neuropathic pain in mice

Kaur,

Muthuraman

2023

RJPT

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Gallic acid (GA) is one of the natural flavonoids and it is known to protect the neuronal system from various endogenous neurodegenerative processes. The present study is focused on evaluating the role of GA in chronic construction injury (CCI) of sciatic nerve-induced neuropathic pain. The test compound i.e., gallic acid (20 and 40mg/kg), and reference compound i.e., pregabalin (PrG: 5mg/kg) were administered intravenously for 10 consecutive days. The sciatic nerve injury-induced neuralgic sensations were assessed with multiple test methods like acetone drop, pinprick, plantar, tail-flick, and tail pinch tests at different time points i.e., 0, 4th, 8th, 12th, and 16th days. The biochemical level changes i.e., thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH), superoxide anion, calcium, myeloperoxidase (MPO), and tumor necrosis factor–α (TNF-α) were estimated in sciatic nerve samples. The administration of GA and PreG was shown a significant ameliorative effect against the CCI-induced pain response in a dose-dependent manner. Moreover, it also attenuated the tissue biochemical changes. The observed effects of GA were similar to reference drug PreG treated groups. Hence, GA has neuroprotective and pain relief effects against the CCI-induced neuralgia. It may be due to its natural free radical scavenging; regulation of inflammatory proteins; expression of antioxidant proteins, reduction of intracellular free calcium, and prevention of neuroinflammatory actions.

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Gallic acid attenuates the Chronic construction injury of sciatic nerve induced neuropathic pain in mice

Kaur,

Muthuraman

2023

RJPT

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Therapeutic potential of Simarouba glauca in treatment of Oral diseases

C. Dony,

G.S.,

Srivastava

2023

RJPT

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Simarouba glauca is an evergreen, flowering tree belonging to family Simaroubaceae. It is commonly called as LaxmiTaru or Paradise Tree. Since ancient times it is widely used as a traditional medicinal plant and different parts of the plant are used for treatment of diseases like malaria, dysentery and cancer. Studies on Simarouba glauca, revealed the presence of several essential phytoconstituents of major pharmacological significance. These phytoconstituents are known to impart a wide range of medicinal properties like anti-cancerous, anti-inflammatory, anti- oxidative, anti-microbial and hemostatic properties to its plant extract.A group of triterpenes called quassinoids is by far the most active phytoconstituent present in Simarouba glauca. In recent years, there is an increase in its popularity as several studies showed its success in treatment of cancers including oral cancer. Also, there is a growing demand for natural products over synthetic drugs as it exhibits less side effects and develop less resistance during drug therapy. However, further in-vivo studies and clinical trials are needed to authenticate the efficiency and safety of Simarouba glauca plant extracts in humans. The purpose of this review is to summarize the therapeutic and medicinal properties of Simarouba glauca and to explore its potential applications in dentistry.

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Evaluation of Leaf extracts of Simarouba glauca on Experimentally Induced Inflammatory Bowel Diseases in Wistar rats

Cited by 2 publications

References 1 publication

Gallic acid attenuates the Chronic construction injury of sciatic nerve induced neuropathic pain in mice

Gallic acid attenuates the Chronic construction injury of sciatic nerve induced neuropathic pain in mice

Therapeutic potential of Simarouba glauca in treatment of Oral diseases

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