Evaluation of Late Toxicities of Patients with Carcinoma of the Cervix Treated with Radical Radiotherapy: An Audit from India

Saibishkumar, Elantholi P.; Patel, Firuza D.; Sharma, Suresh C.

doi:10.1016/j.clon.2005.06.013

Cited by 34 publications

(29 citation statements)

References 27 publications

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“…7,9,43 It has been shown that women >50 years receiving radiotherapy experience higher incidence of vaginal toxicity (stenosis) than women <50 years. 44 Overall, incidence of vaginal toxicity has also been shown to be higher in women receiving ICRT compared with those receiving supplementary radiotherapy (EBRT) only. 44 Ninety percent of our women were >50 years of age, and all of them were treated with ICRT combined with EBRT.…”

Section: Discussionmentioning

confidence: 99%

Chronic fatigue and its correlates in long‐term survivors of cervical cancer treated with radiotherapy

Vistad

Fosså

Kristensen

et al. 2007

BJOG

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Objective To describe the prevalence of chronic fatigue (CF) and associated variables in locoregional cervical cancer survivors (CCSs) surveyed >5 years after radiotherapy. Demographic, clinical and psychological characteristics of the CCSs were compared with normative data.Design Cross-sectional study.Setting Department of Gynaecologic Oncology at RikshospitaletRadiumhospitalet Medical Center, Oslo, Norway.Population Seventy-nine CCSs aged £79 years, treated between 1994 and 1999, representing 62% of those invited. Normative data were based on various population studies of Norwegian women.Methods Data were collected by means of a mailed questionnaire, which included demographic variables and instruments covering fatigue, mental distress, sexual functioning, somatic impairments and quality of life (QOL).Main outcome measures Self-reported fatigue score and caseness of CF based on the fatigue questionnaire.Results CCSs showed 30% CF versus 13% reported in the general population (P = 0.001). CCSs with CF had a significantly lower QOL, higher levels of anxiety and depression and more physical impairments than those without CF. In a multivariable regression model, depression was the only variable significantly associated with CF in CCSs.Conclusions More CCSs have CF than age-matched women in the general population. CF should be of clinical concern since these women also frequently have treatable mental and physical problems.

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Section: Discussionmentioning

confidence: 99%

Chronic fatigue and its correlates in long‐term survivors of cervical cancer treated with radiotherapy

Vistad

Fosså

Kristensen

et al. 2007

BJOG

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“…The simplicity and cost-effectiveness of radiograph-based planning has ensured its continued applicability for dose reporting in brachytherapy [7]. This is especially true in resource-constrained settings which bear the greatest burden of disease [8,9].…”

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confidence: 99%

Can point doses predict volumetric dose to rectum and bladder: a CT-based planning study in high dose rate intracavitary brachytherapy of cervical carcinoma?

Patil

Patel²,

Chakraborty³

et al. 2011

BJR

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Objective: Point doses, as defined by the International Commission on Radiation Units and Measurements (ICRU), are classically used to evaluate doses to the rectum and bladder in high dose rate intracavitary brachytherapy (HDR-ICBT) in cervical cancer. Several studies have shown good correlation between the ICRU point doses and the volumetric doses to these organs. In the present study we attempted to evaluate whether this correlation could be used to predict the volumetric doses to these organs. Methods: A total of 150 HDR-ICBT insertions performed between December 2006 and June 2008 were randomly divided into two groups. Group A (n550) was used to derive the correlation between the point and volumetric doses using regression analysis. This was tested in Group B (n5100) insertions using studentised residuals and Bland-Altman plots. Results: Significant correlations were obtained for all volumetric doses and ICRU point doses for rectum and bladder in Group A insertions. The strongest correlation was found for the dose to 2 cc volumes (D 2cc ). The correlation coefficients for bladder and rectal D 2cc versus the respective ICRU point doses were 0.82 and 0.77, respectively (p,0.001). Statistical validation of equations generated in Group B showed mean studentised residual values of 0.001 and 0.000 for the bladder and rectum. However, Bland-Altman analysis showed that the error range for these equations for bladder and rectum were ¡64% and ¡41% of the point A dose, respectively, which makes these equations unreliable for clinical use. Conclusion: Volumetric imaging is essential to obtain proper information about volumetric doses.

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“…In China, the incidence of radiation proctitis and radiation cystitis following californium-252 (252Cf) neutron intracavitary brachytherapy (ICBT) combined with EBRT was reported as 7.1% and 6.2%, respectively, for patients with Stage IB to IIIB cervical carcinoma (Lei et al, 2011). Impressive results with acceptable late toxicity can be achieved in the treatment of cancer of the cervix using an ideal combination of EBRT and ICRT (Saibishkumar et al, 2006). A similar follow-up study revealed that among 240 cases of Stage I to Stage III cervical carcinoma, 13.3% and 8.8% patients had severe radiation proctitis and radiation cystitis, respectively, following ICBT combined with EBRT (Yu et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Possible Risk Factors Associated with Radiation Proctitis or Radiation Cystitis in Patients with Cervical Carcinoma after Radiotherapy

Yang

Liu²

2012

Asian Pacific Journal of Cancer Prevention

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Radiation proctitis and radiation cystitis are major complications for patients with cervical carcinoma following radiotherapy. In the present study, we aimed to determine the potential risk factors for the development of radiation proctitis and radiation cystitis after irradiation. A total of 1,518 patients with cervical carcinoma received external beam radiotherapy (EBRT) followed by high-dose-rate intracavitary brachytherapy (HDRICB) in our hospital. The incidences of radiation proctitis and radiation cystitis were recorded and associations with different factors (age, time period, tumor stage) were analyzed with c 2 (chi-squared) and Fisher exact tests. We found that 161 and 94 patients with cervical carcinoma were diagnosed with radiation proctitis and radiation cystitis, respectively, following radiotherapy. The prevalence of Grade I-II radiation proctitis or radiation cystitis was significantly lower than that of Grade III (radiation proctitis: 3.82% vs. 6.76%, P < 0.05; radiation cystitis: 2.31% vs. 3.87%, P < 0.05) and was significantly enhanced in patients with late stage (IIIb) tumor progression compared to those in early stage (Ib, IIa) (P < 0.05). Moreover, the incidence of radiation proctitis and cystitis was not correlated with age or, time period following radiation, for each patient (P > 0.05). These observations indicate that a late stage of tumor progression is a potential risk factor for the incidence of radiation proctitis and cystitis in cervical carcinoma patients receiving radiotherapy.

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Evaluation of Late Toxicities of Patients with Carcinoma of the Cervix Treated with Radical Radiotherapy: An Audit from India

Cited by 34 publications

References 27 publications

Chronic fatigue and its correlates in long‐term survivors of cervical cancer treated with radiotherapy

Chronic fatigue and its correlates in long‐term survivors of cervical cancer treated with radiotherapy

Can point doses predict volumetric dose to rectum and bladder: a CT-based planning study in high dose rate intracavitary brachytherapy of cervical carcinoma?

Possible Risk Factors Associated with Radiation Proctitis or Radiation Cystitis in Patients with Cervical Carcinoma after Radiotherapy

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