Evaluation of Lasting High Levels of CRP among the Patients with Metabolic Syndrome

Saiki, Osamu; Kuhara, Makihiko; Kikuchi, Norihisa; Shiraishi, Sanshirou; Uda, Hiroshi

doi:10.1007/s10753-011-9368-7

Cited by 5 publications

(4 citation statements)

References 29 publications

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“…The multiple linear regression analysis showed that hip circumference and WHtR are the main independent variables associated with the levels of hsCRP and IL-6, respectively, in subjects with MetS. These observations are in concordance with the results of previous reports investigating other populations (22,23).…”

Section: Discussionsupporting

confidence: 90%

The Relationship between Metabolic Syndrome, Cardiometabolic Risk Factors and Inflammatory Markers in a Tehranian Population: The Tehran Lipid and Glucose Study

et al. 2012

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Objective The aim of this study was to investigate the relationship between the high sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6) and homocysteine (Hcy) levels and cardiometabolic risk factors in subjects with and without metabolic syndrome (MetS) in a sample of the Tehranian population. Methods In this cross-sectional study, 365 individuals aged ! 19 years were randomly selected from among participants of the Tehran Lipid and Glucose Study (TLGS). The serum levels of IL-6, hsCRP and Hcy were determined using the Enzyme Linked Immunosorbent Assay (ELISA) method. Results Of the 365 subjects, aged a mean of 46.1±16.1 years, MetS was present in 160 (43.8%) individuals. The levels of hsCRP, Hcy and IL-6 were higher in the subjects with MetS. A gradual and significant increase in the levels of hsCRP was found in association with increasing numbers of MetS components after adjusting for sex and age. A strong linear augmentation in the hsCRP levels was observed as the numbers of MetS components increased. Additionally, an increase of 0.40 was observed in the hsCRP levels in association with increases in each component of MetS adjusted for age and sex. The best predictors for the levels of hsCRP, IL-6 and Hcy in the subjects with MetS were hip, waist to height ratio (WHtR) and height, respectively. Conclusion Hip and WHtR are significant predictors of elevated levels of hsCRP and IL-6 associated with MetS, respectively.

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Section: Discussionsupporting

confidence: 90%

The Relationship between Metabolic Syndrome, Cardiometabolic Risk Factors and Inflammatory Markers in a Tehranian Population: The Tehran Lipid and Glucose Study

et al. 2012

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“…Like the participants in our B-MeS group, the metabolic syndrome patients had persistently higher levels of CRP with no clinical symptoms of inflammatory diseases [53, 54]. Higher CRP was found to correlate with visceral obesity also in non-obese young people [38, 55].…”

Section: Discussionmentioning

confidence: 99%

Detection of metabolic syndrome burden in healthy young adults may enable timely introduction of disease prevention

Šoštarič

Jenko

Kozjek

et al. 2019

aoms

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IntroductionMetabolic syndrome and associated diseases are a global health problem. Detection of early metabolic modifications that may lead to metabolic syndrome would enable timely introduction of preventive lifestyle modifications.Material and methodsIn total 103 young, healthy adults were assessed for indicators of metabolic alterations. Anthropometric, lifestyle, genetic and biochemical parameters were assessed. Individuals who fulfilled at least one criterion for diagnosis of metabolic syndrome were assigned to the group with the higher metabolic syndrome burden (B-MeS).ResultsThe 34 young healthy individuals who were assigned to the B-MeS group had lower fat-free mass, higher body mass index, waist-to-hip ratio, fat mass, and blood pressure, more visceral fat, they were less physically active, had higher C-reactive protein values and higher catalase activity. Their phenotype was more similar to that of patients diagnosed with metabolic syndrome than the rest of the population.ConclusionsSimple anthropometric measurements, lifestyle assessment and basic biochemical measurements can be used to identify young healthy individuals with increased risk for metabolic syndrome. These assessments can be performed at periodic check-ups of the healthy population so that timely diagnosis of B-MeS can be made. As lifestyle factors have a big influence on development or improvement of the MeS, the timely diagnosis for B-MeS would enable an early opportunity for intervention for lifestyle modification in the still healthy population, saving costs and reducing disability adjusted life years.

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“…Various air pollutants have demonstrated the ability to induce an acute phase response including ozone, diesel exhaust particles, amphibole asbestos, and single walled carbon nanotubes (Laskin et al 1998, Lewis et al 2007, Erdely et al 2011, Shannahan et al 2012b). Increases in acute phase response proteins have been associated with metabolic syndrome and the eventual development of diabetes and cardiovascular disease (Saiki et al 2011, Wellen, Hotamisligil 2005, Venteclef et al 2011). The release of acute phase response proteins such as C-reactive protein, fibrinogen, and Factor VII from the liver into circulation also promote a prothrombotic state and are recognized as risk factors for myocardial infarction (Donaldson et al 2001, Upadhyay et al 2010, Wilhelmsen et al 1984, Moyssakis et al 2010).…”

Section: Pulmonary-derived Mediator Release and Systemic Effectsmentioning

confidence: 99%

Manufactured and airborne nanoparticle cardiopulmonary interactions: a review of mechanisms and the possible contribution of mast cells

Shannahan

Kodavanti

Brown

2012

Inhalation Toxicology

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Human inhalation exposures to manufactured nanoparticles (NP) and airborne ultrafine particles (UFP) continues to increase in both occupational and environmental settings. UFP exposures have been associated with increased cardiovascular mortality and morbidity, while ongoing research supports adverse systemic and cardiovascular health effects after NP exposures. Adverse cardiovascular health effects include alterations in heart rate variability, hypertension, thrombosis, arrhythmias, increased myocardial infarction, and atherosclerosis. Exactly how UFP and NP cause these negative cardiovascular effects is poorly understood, however a variety of mediators and mechanisms have been proposed. UFP and NP, as well as their soluble components, are known to systemically translocate from the lung. Translocated particles could mediate cardiovascular toxicity through direct interactions with the vasculature, blood, and heart. Recent study suggests that sensory nerve stimulation within the lung may also contribute to UFP- and NP-induced acute cardiovascular alterations. Activation of sensory nerves, such as C-fibers, within the lung may result in altered cardiac rhythm and function. Lastly, release of pulmonary-derived mediators into systemic circulation has been proposed to facilitate cardiovascular effects. In general, these proposed pulmonary-derived mediators include pro-inflammatory cytokines, oxidatively-modified macromolecules, vasoactive proteins, and prothrombotic factors. These pulmonary-derived mediators have been postulated to contribute to the subsequent prothrombotic, atherogenic, and inflammatory effects after exposure. This review will evaluate the potential contribution of individual mediators and mechanisms in facilitating cardiopulmonary toxicity following inhalation of UFP and NP. Lastly we will appraise the literature and propose a hypothesis regarding the possible role of mast cells in contributing to these systemic effects.

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Evaluation of Lasting High Levels of CRP among the Patients with Metabolic Syndrome

Cited by 5 publications

References 29 publications

The Relationship between Metabolic Syndrome, Cardiometabolic Risk Factors and Inflammatory Markers in a Tehranian Population: The Tehran Lipid and Glucose Study

The Relationship between Metabolic Syndrome, Cardiometabolic Risk Factors and Inflammatory Markers in a Tehranian Population: The Tehran Lipid and Glucose Study

Detection of metabolic syndrome burden in healthy young adults may enable timely introduction of disease prevention

Manufactured and airborne nanoparticle cardiopulmonary interactions: a review of mechanisms and the possible contribution of mast cells

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