Evaluation of lactate dehydrogenase enzyme activity in saliva and serum of oral submucous fibrosis patients

Abstract

This study provides additional rationale for the role of salivary LDH in the early diagnosis and prognosis of oral submucous fibrosis.

Quantitative analysis of lactate dehydrogenase, albumin and uric acid levels in saliva and serum of Sudanese snuff dippers

“…In the present study the level of salivary lactate dehydrogenase in toombak dippers was found higher than the level of the enzyme concentration in the control group , while the level of the enzyme in OSCC patients was found lower than the level in control group. The results of the present study agreed with the study held by Sivaramakrishnanet al 27 on oral submucous fibrosis when they reported lower level of enzyme concentration in OSCC patients group compared to control group.The results contradicted with the findings ofthe findings of Josti 28 , who reported an overall steadily increasing levels of enzyme concentration, matching the progress in cancer lesion.The results of the study are inconsistent with the findings of Lockshet al 29 , who reported statistically significant difference between the level in the control group, and the level in patients group.…”

“…Shircant and Rashmi 26 revealed that are very few studies have been done in serum and saliva lactatedehydrogenase in patients with OSCC 27 .Salivary lactate dehydrogenase levels of the different groups in the present study ( Table 2) showed slight difference that was not statistically significant. In the present study the level of salivary lactate dehydrogenase in toombak dippers was found higher than the level of the enzyme concentration in the control group , while the level of the enzyme in OSCC patients was found lower than the level in control group.…”

Lactate Dehydrogenase as a Tumor Marker in Oral Cancer and Oral Potentially Malignant Disorders: A Biochemical Study

“…The comparison of salivary LDH levels between OSMF and healthy subjects was statistically significant (p < 0.001). Our study findings were consistent with the study conducted by Sivaramakrishnan et al, 3 Kallalli et al, 1 Bhambal et al, 2 Shetty et al, 16 Rathore et al, 9 Pereira et al, 6 and Muralidhar et al 14 According to WHO 2005, oral leukoplakia is defined as a predominantly white patch or plaque that cannot be characterized clinically or pathologically as any other disorder; oral leukoplakia carries an increased risk of cancer development either in or close to the area of leukoplakia or elsewhere in the oral cavity or the head and neck region. 17 Malignant transformation rate of oral leukoplakia varies from 0.13 to 34%.…”

“…The LDH enzyme activity in OSMF is mainly related to following factors: Hypoxia, alteration in glycolysis, and fibrosis. 3 On comparing the serum LDH levels in OSMF groups and healthy controls in our study, we found that serum LDH levels in OSMF cases were greater than in healthy controls. This comparison was statistically significant (p < 0.001).…”

“…1 Oral cancer is often preceded by potentially malignant disorders (PMDs), with more emphasis being placed on early detection, since diagnosis at an early stage is comparatively easier and is the key to reduce mortality and morbidity. 2,3 Recently, the role of tumor markers in the management of head and neck cancer has increased for attention. 4 Tumor markers are biologically elaborated by tumor cells due to either the cause or effect of malignant process substances.…”