2017
DOI: 10.1002/dta.2154
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Evaluation of KIMS immunoassays on a cobas c 501 analyzer for drugs of abuse and ethyl glucuronide testing in urine for forensic abstinence control

Abstract: For the medico-psychological assessment (MPA) during driving licence re-granting in Germany, abstinence control including urine samples is required. In these programmes, even small amounts of markers for drug or alcohol abuse have to be detected. Thus, the concentrations of the target compounds are very low, and, in consequence, the sensitivity of the applied screening method has to be much higher than for clinical use. Modified drugs of abuse and ethyl glucuronide immunoassays on a Roche cobas c 501 analyzer … Show more

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Cited by 5 publications
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“…Ethyl glucuronide (EtG) is a direct, minor metabolite of ethanol that is routinely used as a biomarker for recent drinking. EtG measurement has become an established complementary parameter in urine drug testing and commercial immunochemical screening tests are available [1,2]. To secure a preliminary positive immunoassay EtG result, mass spectrometry (MS) methods are used and often include also measurement of ethyl sulfate (EtS), another conjugated ethanol metabolite [3], to confirm alcohol intake [4,5].…”
Section: Introductionmentioning
confidence: 99%
“…Ethyl glucuronide (EtG) is a direct, minor metabolite of ethanol that is routinely used as a biomarker for recent drinking. EtG measurement has become an established complementary parameter in urine drug testing and commercial immunochemical screening tests are available [1,2]. To secure a preliminary positive immunoassay EtG result, mass spectrometry (MS) methods are used and often include also measurement of ethyl sulfate (EtS), another conjugated ethanol metabolite [3], to confirm alcohol intake [4,5].…”
Section: Introductionmentioning
confidence: 99%