Evaluation of jawbone morphology and bone density indices in panoramic radiographs of selective serotonin reuptake inhibitor users: a preliminary study

Gupta, Brijen K.; Acharya, Aneesha; Singh, Shilpa; Brazzoli, Stefania; Ghorab, Mahmoud M.; Malik, Shaima; Pelekos, George; Rossouw, Emile

doi:10.1259/dmfr.20170360

Cited by 5 publications

(3 citation statements)

References 57 publications

(74 reference statements)

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“…They suggested that since CBCT has higher radiation dose and lower image resolution, panoramic radiography is more advantageous for the examination of trabecular bone. In the literature, there are also many studies that panoramic morphometric indices were used successfully to deduce possible disease or drug-related osteoporotic conditions in craniofacial bones [ 31 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

The effects of vitamin D deficiency on mandibular bone structure: a retrospective radiological study

et al. 2022

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Objective The aim of the study was to evaluate the effects of vitamin D deficiency on the mandibular bone structure by fractal analysis and panoramic morphometric indices. Methods Ninety participants were divided into three groups as 30 individuals with severe vitamin D deficiency, 30 individuals with vitamin D deficiency, and 30 individuals with vitamin D sufficiency. Fractal dimension analysis (FD), panoramic mandibular index (PMI), mandibular cortical index (MCI), and mandibular cortical thickness measurement (CTM) were evaluated on panoramic radiographs. Results FD values of the patients with vitamin D deficiency were found to be statistically lower than the patients with vitamin D sufficiency ( p < 0.05). FD value of supracortical area above the angulus mandible (FD2) in patients with severe vitamin D deficiency was significantly lower than FD values ( p = 0.002). There was no statistically significant difference between the groups in the CTM ( p > 0.05). PMI was significantly lower in patients with severe vitamin D deficiency ( p < 0.001). There was a significant difference in MCI values between the groups ( p < 0.05). Conclusion Vitamin D deficiency causes a decrease in bone mineral density in the mandible, and an increase in alveolar porosity. FD analysis and radiomorphometric indices in panoramic radiographs can be used to assess osteoporotic changes in patients with vitamin D deficiency.

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Section: Discussionmentioning

confidence: 99%

The effects of vitamin D deficiency on mandibular bone structure: a retrospective radiological study

et al. 2022

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“…20 Gupta et al evaluated the effect of selective serotonin reuptake inhibitors by using morphometric analysis on panoramic radiographs. 37 They stated that KI was the strongest predictor of drug-related osteoporotic alterations. 37 On the other hand, in a study by Allen et al, in which the researchers evaluated the compatibility of the BMD values for the mandible with KI by using quantitative computed tomography (QCT) and panoramic radiography, it was observed that KI was not compatible with the mineral density of the bone.…”

Section: Discussionmentioning

confidence: 99%

“…37 They stated that KI was the strongest predictor of drug-related osteoporotic alterations. 37 On the other hand, in a study by Allen et al, in which the researchers evaluated the compatibility of the BMD values for the mandible with KI by using quantitative computed tomography (QCT) and panoramic radiography, it was observed that KI was not compatible with the mineral density of the bone. 38 On the contrary, in the current study, the C2 index frequency was higher in the study group.…”

Section: Discussionmentioning

confidence: 99%

Does childhood chemotherapy affect mandibular bone structures in a lifetime?

Kış¹,

Coşgunarslan²,

Delikan³

et al. 2022

Dent. Med. Probl.

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Background. Chemotherapy, one of the most important treatment modalities for treating childhood cancers, is a major cause of bone loss in patients and survivors.Objectives. This study aimed to evaluate mandibular bone structures in childhood cancer survivors (CCSs) by means of fractal dimension (FD) analysis and the Klemetti index (KI), and to compare them with regard to the control group. Material and methods.In this retrospective study, the panoramic radiographs of 49 CCSs were included as the study group and the panoramic radiographs of 49 cancer-free volunteers were included as the control group. Based on the panoramic radiographs, FD and KI were determined.Results. No significant differences were observed between the study and control groups in terms of mean FD values for regions of interest (ROIs) ROI_1, ROI_2 and ROI_3 (p = 0.750, p = 0.490 and p = 0.910, respectively). The mean FD values for ROI_1 for the study and control groups were 1.08 ±0.18 and 1.07 ±0.14, respectively. The mean FD values for ROI_2 for the study and control groups were 1.11 ±0.13 and 1.09 ±0.13, respectively. The mean FD values for ROI_3 for the study and control groups were 1.15 ±0.14 and 1.15 ±0.15, respectively. Statistically significant differences between the study and control groups were noted only in the distribution of the KI categories (p = 0.015). Conclusions.Childhood chemotherapy may affect mandibular bone structures during a lifetime. The Klemetti index should be considered a useful clinical diagnostic tool for the examination of mandibular bone structures.

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The effect of selective serotonin reuptake inhibitors on the human mandible

et al. 2020

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Evaluation of jawbone morphology and bone density indices in panoramic radiographs of selective serotonin reuptake inhibitor users: a preliminary study

Abstract: SRRI use was significantly associated with worse panoramic morphometric indices: KI, condylar pathology, ramus height, and MCW, where KI was its strongest predictor. Worse KI was independently predicted by SSRI use.

Cited by 5 publications

References 57 publications

The effects of vitamin D deficiency on mandibular bone structure: a retrospective radiological study

The effects of vitamin D deficiency on mandibular bone structure: a retrospective radiological study

Does childhood chemotherapy affect mandibular bone structures in a lifetime?

The effect of selective serotonin reuptake inhibitors on the human mandible

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