Evaluation of isoflavone content and antioxidant activity of selected soy taxa

Szymczak, Grażyna; Wójciak–Kosior, Magdalena; Sowa, Ireneusz; Zapała, Karolina; Strzemski, Maciej; Kocjan, Ryszard

doi:10.1016/j.jfca.2016.12.015

Cited by 32 publications

(21 citation statements)

References 20 publications

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“…In fact, isoflavones consist of two forms, aglycone forms and conjugated forms including glucoside type, acetylgucoside type, and malonyglucoside type. Approximate isoflavone contents of soybean and its products from various experiment researches are shown in Table (Zhu, Hettiarachchy, Horax, & Chen, ; Ishihara, Singh, Chung, & Tam, ; Baiano, Terracone, Gambacorta, & La Notte, ; Chan et al., ; Cvejic, Tepavcevic, Bursac, Miladinovic, & Malencic, ; Oh, Hwang, & Lim, ; Ma & Huang, ; Chen & Chang, ; Xu, Bin, & Xu, ; Kumari & Chang, ; Szymczak et al., ; Morales‐de La Pena, Martin‐Belloso, & Welti‐Chanes, ; Lee, Hwang, Son, & Cho, ; Niyibituronsa et al., ). Although the amount of aglycone form was little in natural food, it could be elevated greatly after fermentation.…”

Section: Discussionmentioning

confidence: 99%

Effect of Genistein on Cholesterol Metabolism‐Related Genes in HepG2 Cell

Zheng

Yin

et al. 2019

Journal of Food Science

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It has been reported that genistein could improve metabolic syndromes. Our study aimed to investigate the effects and potential mechanisms of genistein on improving cholesterol metabolism in HepG2 cell. HepG2 cells were cultured with 0, 0.01, 1.00, 10.00, and 50.00 µM genistein for 24 hr. The current results showed a dose‐dependent manner between genistein and intracellular contents of total cholesterol (TC), high‐density lipoprotein‐cholesterol (HDL‐C), and cellular apolipoprotein A1 (Apo‐A1) secretion. TC was increased by 25.69%, meanwhile HDL‐C and Apo‐A1 were decreased by 56.00% and 25.93%, respectively, when the dosage of genistein was 1.00 µM. Genistein dose‐dependently upregulated the protein and mRNA levels of sterol regulatory element binding proteins‐2 (SREBP‐2), as well as the mRNA levels of low‐density lipoprotein receptor (LDLR) and 3‐hydroxy‐3‐methyl glutaryl coenzyme A reductase (HMGCR), by 145.91%, 72.29%, 310.23%, and 123.08%, respectively, when we gave 1.00 µM genistein, indicating that intracellular cholesterol synthesis and absorption of exogenous cholesterol were increased. In addition, the mRNA levels of peroxisome proliferator‐activated receptor‐γ (PPARγ) and liver X receptor (LXRα), lowered by 58.23% and 34.86% at 0.01 µM genistein, were reduced in a dose‐dependent manner. LXRα and ATP‐binding cassette transporter A1 (ABCA1) protein levels were significantly (P < 0.05) decreased by 50.35% and 11.60% at 1.00 µM genistein, which indicated that cellular cholesterol efflux was inhibited. Taken together, our results suggested that genistein at dosage of more than 1.00 µM was able to increase the intracellular cholesterol levels by up regulating SREBP‐2/LDLR/HMGCR pathway and suppressing PPARγ/LXRα/ABCA1 pathway. Practical Application In this study, genistein appeared to be effective in reducing plasma cholesterol levels due to increase the intracellular cholesterol levels by upregulating cholesterol absorption through SREBP‐2/LDLR/HMGCR pathway, and also downregulating cholesterol efflux via PPARγ/LXRα/ABCA1 pathway in vitro. In addition, plasma cholesterol is regarded as the key indicator of atherosclerosis; therefore, we believe that our findings could be used for further exploration on a possible therapeutic application of genistein for atherosclerosis.

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Section: Discussionmentioning

confidence: 99%

Effect of Genistein on Cholesterol Metabolism‐Related Genes in HepG2 Cell

Zheng

Yin

et al. 2019

Journal of Food Science

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“…Soy isoflavones are diphenolic compounds present in plants, such as soybeans, red clover, and kudzu root, and there is growing evidence that they exhibit strong bioactivities as antiobesity (Wang, Wang, Pan, & Ho, ), anticancer (Kucuk, ), antioxidant (Szymczak et al., ), and other beneficial effects on the human body (Hu et al., ; Kucuk, ; Szymczak et al., ; Vázquez, Flórez, Guadamuro, & Mayo, ; Wang & Wu, ; Wang et al., ).…”

Section: Perspectives In Nutrient Recovery From Fvpi Wastewatermentioning

confidence: 99%

Recovery of High Value‐Added Nutrients from Fruit and Vegetable Industrial Wastewater

Chen

Zhang

Tian

et al. 2019

Comp Rev Food Sci Food Safe

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The industrial processing water of fruit and vegetables has raised serious environmental concerns due to the presence of many important bioactive compounds being disposed in the wastewater. Bioactive compounds have great potential for the food industry to optimize their process and to recover these compounds in order to develop value‐added products and to reduce environmental impacts. However, to achieve this goal, some challenges need to be addressed such as safety assurance, technology request, product regulations, cost effectiveness, and customer factors. Therefore, this review aims to summarize the recent advances of bioactive compounds recovery and the current challenges in wastewater from fruit and vegetable processing industry, including fruit and beverage, soybean by‐products, starch and edible oil industry. Moreover, future direction for novel and green technology of bioactive compounds recovery are discussed, and a prospect of bioactive compounds reuse and sustainable development is proposed.

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“…The ability of isoflavones to mimic estrogen molecules in their ability to bind to RE is more pronounced in the case of genistein and daidzein and their derivative compounds [ 21 ]. These are the main isoflavones found in soybean, predominantly being daidzin, malonyldaidzin, genistin, and malonylgenistin (the glycosylated forms and, respectively, malonyl-derivatives of genistein and daidzein) [ 22 ]. Along with these substances, glycitein and glycitin (glycosylated form) are present in a smaller amount [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of the Hormone Replacement Therapy and of Soy Isoflavones on Bone Resorption in Postmenopause

Ţiţ

Bungău

Iovan

et al. 2018

JCM

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Postmenopausal osteoporosis is the most common form of osteoporosis and one of the major public health problems in developed countries. The prevalence of this condition, associated with the physiological stage of menopause, is continuously increasing. This study evaluated the effectiveness of soy isoflavones as compared to hormone replacement therapy (HRT) in low doses, on the prevention of postmenopausal osteoporosis, by determining bone mineral density (BMD) and urinary deoxypyridinoline (D-pyr) in physiological postmenopausal women. The study was conducted over a period of 12 months, on three parallel groups, which included a total of 325 postmenopausal women (HRT group: n = 95; phytoestrogens group: n = 124; control group: n = 106). At the one-year evaluation, we observed T-score normalization in a small number of cases (5.26%, 2.42% and 0.00%, respectively). The average values of D-Pyr decreased by 11.38% in the group treated with phytoestrogens (p < 0.05) and by 15.32% in the group that followed HRT (p < 0.05); it increased by 4.38% in the control group (p > 0.05). Both therapies have beneficial effects on bone metabolism, leading to a significant decrease in the evolution of bone resorption and there are no major differences between the efficacy of HRT and phytoestrogens in terms of the effects on BMD and bone resorption.

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Evaluation of isoflavone content and antioxidant activity of selected soy taxa

Cited by 32 publications

References 20 publications

Effect of Genistein on Cholesterol Metabolism‐Related Genes in HepG2 Cell

Effect of Genistein on Cholesterol Metabolism‐Related Genes in HepG2 Cell

Recovery of High Value‐Added Nutrients from Fruit and Vegetable Industrial Wastewater

Effects of the Hormone Replacement Therapy and of Soy Isoflavones on Bone Resorption in Postmenopause

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