Evaluation of involvement of testicular metallothionein gene expression in the protective effect of zinc against cadmium-induced testicular pathophysiology in rat

Messaoudi, Imed; Bannı, Mohamed; Said, Lamia; Saïd, Khaled; Kerkeni, Abdelhamid

doi:10.1016/j.reprotox.2010.01.004

Cited by 50 publications

(37 citation statements)

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“…Zn is one of the most important nutritional factors influencing the metabolism and toxicity of Cd [18]. The protective effect of Zn in condition of Cd exposure in animals has been demonstrated for many years by our and others research groups [11,17,48]. As shown in the present work, the concomitant treatment with Cd and Zn reduced Cd transfer from dams to the fetus during pregnancy and its accumulation in the testis during postnatal development.…”

Section: Discussionsupporting

confidence: 70%

“…The hypothesis that Zn can protect testicular tissue against Cd-induced testicular damage in adult rats was established by our and several other previous studies [8,11,20]. In addition, studies demonstrated that gestational and lactational exposure to Cd may produce adverse effects in the offspring, resulting in developmental, reproductive and behavioural deficits [21][22][23][24].…”

Section: Discussionmentioning

confidence: 88%

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Protective role of zinc against the toxicity induced by exposure to cadmium during gestation and lactation on testis development

Chemek

Mimouna

Boughammoura

et al. 2016

Reproductive Toxicology

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Highlights Effects of Cd and Zn on testicular development were assessed. Cd accumulation and Zn depletion in testis during lactation were noted. Cd-induced abnormal seminiferous tubules and a plasmatic testosterone decrease. Zn supply induced a significant protection against Cd toxicity. Cd toxicity observed in pups is mediated by disruption of maternal Zn metabolism. *Research Highlights AbstractTo assess the effects of exposure to Cd and Zn on rat testicular development, offspring, from mothers receiving either tap water, Cd, Zn or Cd+Zn during gestation and lactation periods, were observed on gestational day (GD) 20 and on postnatal days (PND) 12, 21 and 35. During gestation, Cd induced maternal hypozincemia and less transfer of Zn to the fetus. During lactation, progressive Cd accumulation and Zn depletion in testis at PND12 and PND21 werenoted. An increase of abnormal seminiferous tubules and a decrease in testis weight and plasmatic testosterone concentration were also observed at PND21 and PND35 respectively. Interestingly, Zn supply induced a significant protection against Cd toxicity. These results suggest that the toxic effects of Cd observed during development are mediated by the disruption of Zn metabolism, which is established in mothers during pregnancy causing Zn deficiency in fetuses and continues to become more pronounced during lactation.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 88%

Protective role of zinc against the toxicity induced by exposure to cadmium during gestation and lactation on testis development

Chemek

Mimouna

Boughammoura

et al. 2016

Reproductive Toxicology

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“…The adverse effects of cadmium on histological structure of reproductive tissues have been reported even after administration of single doses where acute Cd injection caused some necrotic and apoptotic changes in the seminefrous tubular epithelium as well as edema, congestion, hemorrhage of testes besides diffuse necrosis of spermatozoa with impaired spermatogenesis as reported by Messaodi et al (2010) and El-shahat et al (2009). On the same context, Adamkovičová et al (2010) also reported that I/P injection of a single dose of Cd (2 mg/kg body weight) to adult rats showed necrosis of seminiferous tubular epithelium, disruption of blood-testis barrier leading to edema and ischemia.…”

Section: Discussionmentioning

confidence: 88%

Evaluating the ameliorative efficacy of Spirulina platensis on spermatogenesis and steroidogenesis in cadmium-intoxicated rats

Farag

El-Aziz

Ali

et al. 2015

Environ Sci Pollut Res

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The present study was conducted to evaluate the ameliorative efficacy of Spirulina platensis (SP) on reproductive dysfunctions induced by cadmium chloride (CdCl2) in male rats. Rats (n = 40) were divided into five groups (eight rats/each). Group 1: served as control without any treatment. Group 2: Rats were administered SP (150 mg/kg body weight (BW)) in drinking water for 10 days. Group 3: Rats were subcutaneously injected with CdCl2 (2 mg/kg BW) daily for 10 days. Group 4: Rats were co-treated with both CdCl2 (2 mg/kg BW) and SP (150 mg/kg BW) daily for 10 days (SP prophylactic group). Group 5: Rats received CdCl2 for 10 days followed by administration of SP alone in drinking water daily for another 30 days with the same mentioned routes and doses (SP treatment group). From our findings, the administration of SP alone or co-administration with Cd significantly attenuated the harmful effects of Cd, suggesting its beneficial role in improving spermatogenesis and steroidogenesis after Cd exposure.

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“…Moreover, Santos et al (2004) reported that endothelial damage of the small blood vessels, oedema and haemorrhage of the rat testes can be demonstrated by using just a single parenteral dose of Cd chloride at 2-4 mg kg -1 . Several studies focusing on Cd-related changes in testicular histopathology have implicated testicular blood vessel damage, followed by the degeneration of spermatopoietic epithelial, as the main cause of Cd toxicity (Thompson & Bannigan, 2008;Messaoudi, Banni, Said, Said, & Kerkeni, 2010).…”

Section: Resultsmentioning

confidence: 99%

<b>Semen traits, testicular morphometry and histopathology of cadmium-exposed rabbit bucks administered methanolic extract of <i>Phoenix dactylifera</i> fruit

Ansa¹,

Akpere²,

Imasuen³

2017

Acta Sci. Anim. Sci.

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ABSTRACT. This study evaluated the effect of Cd on some male reproductive parameters; and explored the therapeutic potentials of methanolic extract of Phoenix dactylifera (MEPD) fruit in averting such reproductive damages. 45 rabbit bucks aged 24-28 weeks and weighing 1.41-1.43 kg was used. The rabbits were assigned to 5 treatment groups (control, Cd-only, Cd + 300 mg MEPD, Cd + 600 mg MEPD and Cd + 900 mg MEPD) in a completely randomized design. The rabbits were dosed with 3 mg CdCl 2 kg -1 feed for 7 days followed by MEPD for 56 days after every 72 hours. Result of semen evaluation indicates that semen volume, motility, libido, concentration, total ejaculate, viability and morphology were significantly reduced by Cd compared to the normal control group. Testis density and epididymis length of the control rabbits were significantly different from the Cd-only exposed rabbits. Histopathological examination revealed severe testicular damage due to Cd. Indeed, treatment with MEPD significantly reversed the deleterious reproductive effects caused by Cd. In conclusion, cadmium drastically affected the testis of rabbits and treatment with MEPD alleviated some deleterious effects.Keywords: testis, sperm, heavy metal, methanol, plant extract.Características do sêmen, morfometria testicular e histopatologia de cadáveres de coelho expostos, administrado extrato metanólico de frutos de Phoenix dactylifera RESUMO. Este estudo avaliou o efeito da Cd em alguns parâmetros reprodutivos masculinos e explorou os potenciais terapêuticos de extrato metanólico de Phoenix dactylifera (MEPD), fruto na prevenção de tais danos reprodutivos. Foram utilizados 45 machos de coelho com idade entre 24-28 semanas e pesando 1,41-1,43 kg. Os coelhos foram designados a cinco grupos de tratamento (controle, Cd-apenas, Cd+300 mg MEPD, Cd+600 mg MEPD e Cd+900 mg MEPD) num delineamento inteiramente casualizado. Os coelhos foram doseados com 3 mg de CdCl2 kg -1 de alimento durante sete dias seguido por MEPD durante 56 dias após cada 72h. O resultado da avaliação do sêmen indica que o volume de sêmen, a motilidade, a libido, a concentração, a ejaculação total, a viabilidade e a morfologia foram significativamente reduzidos pelo Cd em comparação com o grupo controle normal. A densidade do testículo e o comprimento do epidídimo dos coelhos de controle foram significativamente diferentes dos coelhos expostos. O exame histopatológico revelou dano testicular grave devido ao Cd. Na verdade, o tratamento com MEPD reverteu significativamente os efeitos deletérios reprodutivos causados por Cd. Em conclusão, o cádmio afetou muito os testículos de coelhos e o tratamento com MEPD aliviou alguns efeitos deletérios.Palavras-chave: testículo, esperma, metal pesado, metanol, extrato vegetal.

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Evaluation of involvement of testicular metallothionein gene expression in the protective effect of zinc against cadmium-induced testicular pathophysiology in rat

Cited by 50 publications

References 52 publications

Protective role of zinc against the toxicity induced by exposure to cadmium during gestation and lactation on testis development

Protective role of zinc against the toxicity induced by exposure to cadmium during gestation and lactation on testis development

Evaluating the ameliorative efficacy of Spirulina platensis on spermatogenesis and steroidogenesis in cadmium-intoxicated rats

<b>Semen traits, testicular morphometry and histopathology of cadmium-exposed rabbit bucks administered methanolic extract of <i>Phoenix dactylifera</i> fruit

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