Evaluation of intramyocellular and extramyocellular lipids in the paraspinal muscle in patients with chronic low back pain using MR spectroscopy: preliminary results

Takashima, Hiroyuki; Takebayashi, Toru; Ogon, Izaya; Yoshimoto, Mitsunori; Terashima, Yoshiaki; Imamura, Rui; Yamashita, Toshihiko

doi:10.1259/bjr.20160136

Cited by 22 publications

(33 citation statements)

References 42 publications

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“…We previously reported that IMCLs using MRS analysis in the Mm of patients with CLBP was significantly higher than that of asymptomatic volunteers. 26 However, sagittal spinopelvic alignment tended to be different between patients with chronic LBP and asymptomatic volunteers. 27 Therefore, we needed the control group with the same sagittal spinopelvic alignment as the CLBP group to investigate the connection among IMCLs, EMCLs and CLBP.…”

Section: Discussionmentioning

confidence: 96%

“…26 In brief, the Signa HDx 1.5-T MRI system (GE Healthcare, Milwaukee, WI) with a spine coil was used to obtain T 2 weighted sagittal and transverse MR images. From these images, the proton MRS volume of interest (VOI) was positioned in the centre of the Mm at L4/L5 for the right side ( Figure 3).…”

Section: Mri Protocol and Analysis For Mr Spectroscopic Datamentioning

confidence: 99%

“…6,24,25 We previously reported that IMCLs using MRS analysis in the Mm of patients with CLBP were significantly higher than in asymptomatic volunteers. 26 Some reports have described the associations of spinopelvic alignment with LBP [27][28][29] and fatty atrophy of Mm; 7,30 however, the association of IMCLs and EMCLs with spinopelvic alignment in patients with CLBP remains unclear. The aims of the present study were to analyze IMCLs and EMCLs of the Mm using MRS in CLBP and control groups and to identify possible correlations with spinopelvic alignment.…”

Section: Introductionmentioning

confidence: 99%

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Magnetic resonance spectroscopic analysis of multifidus muscles lipid content and association with spinopelvic malalignment in chronic low back pain

Ogon

Takebayashi

Takashima

et al. 2017

BJR

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Objective: To analyze intramyocellular lipids (IMCLs) and extramyocellular lipids (EMCLs) of the multifidus muscle (Mm) using MR spectroscopy in chronic low back pain (CLBP) and control groups and to identify correlations with spinopelvic alignment. Methods: 40 patients (16 males, 24 females; mean age, 62.9 6 1.9 years) whose visual analogue scale scores were .30 mm for CLBP were included. Furthermore, 40 control participants matched with the CLBP group subjects by sample size, gender and age (17 males, 23 females; mean age, 65.0 6 1.2 years) were included. We compared the body mass index, physical workload, leisure time physical activity level, spinopelvic parameters, and IMCLs and EMCLs of the Mm between the groups. We also evaluated possible correlations of spinopelvic parameters with IMCLs and EMCLs of the Mm in the groups.

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Section: Discussionmentioning

confidence: 96%

Section: Mri Protocol and Analysis For Mr Spectroscopic Datamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Magnetic resonance spectroscopic analysis of multifidus muscles lipid content and association with spinopelvic malalignment in chronic low back pain

Ogon

Takebayashi

Takashima

et al. 2017

BJR

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“…However, elevated levels of TAG 50:2 in circulation may represent the early cascade of alterations in cardiovascular risk factors and intramyocellular storage that have been associated with LBP (Goodson et al, 2013; Leino-Arjas et al, 2006; Takashima et al, 2016). To date, we are not aware of any studies that have examined lipid levels in relation to peripheral and central sensitivity, although fat distribution has been shown to influence pressure pain threshold.…”

Section: Discussionmentioning

confidence: 99%

“…It has been posited that the increase in circulating lipids among individuals with LBP contributes to lumbar artherosclerosis, resulting in accelerated degenerative disc disease and higher fat content of the multifidus muscle (Mengiardi et al, 2006). More detailed investigation of the lipid content of the multifidus muscle revealed an increase in intramyocellular lipids in patients with LBP compared to asymptomatic volunteers (Takashima et al, 2016). Although it is currently unclear whether elevated levels of circulating lipids increase vulnerability to developing chronic LBP, both higher BMI and triglyceride levels have been reported in patients with chronic LBP compared to healthy controls (Rinaldo et al, 2016).…”

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confidence: 99%

Circulating Lipids and Acute Pain Sensitization

Starkweather¹,

Julian

Ramesh³

et al. 2017

Nursing Research

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Background In individuals with low back pain, higher lipid levels have been documented and were associated with increased risk for chronic low back pain. Objectives The purpose of this research was to identify plasma lipids that discriminate participants with acute low back pain with or without pain sensitization as measured by quantitative sensory testing. Methods This exploratory study was conducted as part of a larger parent randomized controlled trial. A cluster analysis of 30 participants with acute low back pain revealed two clusters: one with signs of peripheral and central sensitivity to mechanical and thermal stimuli and the other with an absence of peripheral and central sensitivity. Lipid levels were extracted from plasma and measured using mass spectroscopy. Results TAG 50:2 was significantly higher in participants with peripheral and central sensitization compared to the nonsensitized cluster. The nonsensitized cluster had significantly higher levels of PG 34:2, plasmenyl-PC 38:1, and PA 28:1 compared to participants with peripheral and central sensitization. Linear discriminant function analysis was conducted using the four statistically significant lipids to test their predictive power to classify those in the sensitization and no sensitization clusters; the four lipids accurately predicted cluster classification 58% of the time (R2 = .58 (−2 log likelihood = 14.59). Discussion The results of this exploratory study suggest a unique lipidomic signature in plasma of patients with acute low back pain based on the presence or absence of pain sensitization. Future work to replicate these preliminary findings is underway.

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Imaging diagnosis for intervertebral disc

Ogon

Takebayashi²,

Takashima

et al. 2019

JOR Spine

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Various functional magnetic resonance imaging (MRI) techniques have been investigated in recent years and are being used in clinical practice for the patients with low back pain (LBP). MRI is an important modality for diagnosing intervertebral disc (IVD) degeneration. In recent years, there have been several reported attempts to use MRI T2 mapping and MRI T1ρ mapping to quantify lumbar disc degeneration. MRI T2 mapping involves digitizing water content, proteoglycan content, and collagen sequence breakdown as relaxation times (T2 values) at each site. These digitized values are used to create a map, that is, then used to quantitatively evaluate the metabolite concentrations within IVD tissues. MRI T2 mapping utilizes the T2 relaxation time to quantify moisture content and the collagen sequence breakdown. MRI T1ρ mapping digitizes water molecule dispersion within the cartilaginous matrix to evaluate the degree of cartilaginous degeneration. Magnetic resonance spectroscopy is a less‐invasive diagnostic test that provides biochemical information. Adequate analysis of the IVD has not yet been performed, although there are indications of a relationship between the adipose content of the multifidus muscle in the low back and LBP. The ultra short TE technique has been recently used to investigate lumbar cartilaginous endplates. Unlike diagnosis based on contrast‐enhanced images of the IVD, which depends on the recurrence of pain that is determined subjectively, MRI‐based diagnosis is less‐invasive and based on objective imaging findings. It is therefore expected to play a key role in the diagnostic imaging of IVD conditions in the future.

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Evaluation of intramyocellular and extramyocellular lipids in the paraspinal muscle in patients with chronic low back pain using MR spectroscopy: preliminary results

Abstract: We investigated the detail of the fat content in the paraspinal muscles in patients CLBP and asymptomatic volunteers. The increase of fat content in the Mm of patients with LBP on previous studies was demonstrated to be the increase of IMCL.

Cited by 22 publications

References 42 publications

Magnetic resonance spectroscopic analysis of multifidus muscles lipid content and association with spinopelvic malalignment in chronic low back pain

Magnetic resonance spectroscopic analysis of multifidus muscles lipid content and association with spinopelvic malalignment in chronic low back pain

Circulating Lipids and Acute Pain Sensitization

Imaging diagnosis for intervertebral disc

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