Evaluation of Intra‐ and Interscanner Reliability of MRI Protocols for Spinal Cord Gray Matter and Total Cross‐Sectional Area Measurements

Papinutto, Nico; Henry, Roland G.

doi:10.1002/jmri.26269

Cited by 21 publications

(28 citation statements)

References 33 publications

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“…This is in line with an average area of about 80 mm 2 as detected in the previous study for CSA in the 20‐25 years range 10 . Although different acquisition protocols were used in the two studies, we previously showed that, using Jim, they provide comparable CSA estimates 8 …”

Section: Resultssupporting

confidence: 90%

“…Recent advancements in magnetic resonance imaging (MRI) technology have allowed for the acquisition of high‐resolution SC magnetic resonance (MR) images at cervical and thoracic levels. In particular, T2*‐weighted and phase sensitive inversion recovery (PSIR) sequences have been developed and used to quantitatively assess GM/WM damage in neurodegenerative diseases of the CNS 7,8 . In the absence of cutting‐edge SC dedicated acquisitions, SC atrophy at the upper cervical levels (defined in terms of cross‐sectional area [CSA]) can be assessed using routinely acquired T 1 ‐weighted brain scans that include the upper cervical cord 9 …”

Section: Introductionmentioning

confidence: 99%

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MRI Measurement of Upper Cervical Spinal Cord Cross‐Sectional Area in Children

Papinutto

Cordano

Asteggiano

et al. 2020

Journal of Neuroimaging

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BACKGROUND AND PURPOSE: Neurological and neurodegenerative diseases can affect the spinal cord (SC) of pediatric patients. Magnetic resonance imaging (MRI) allows for in vivo quantification of SC atrophy via cross-sectional area (CSA). The study of CSA values in the general population is important to disentangle disease-related changes from intersubject variability. This study aimed at providing normative values for cervical CSA in children, extending our previous work performed with adults. METHODS: Seventy-eight children (age 7-17 years) were selected from a Developmental Dyslexia study. All subjects underwent a 3T brain MRI session and any incidental findings were reported on the scans. A sagittal 1 mm 3 3-dimensional T 1-weighted brain acquisition extended to the upper cervical cord was used to measure CSA at C2-C3, as well as spinal canal area and skull volume (V-scale). These three metrics were linearly fitted as a function of age to extract trends and percentage annual changes. Sex differences of CSA were assessed using least squares regression analyses, adjusting for age. We tested normalization strategies proven to be effective in reducing the intersubject variability of adults' CSA. RESULTS: CSA changed as a function of age at a faster rate when compared with skull volume (CSA: 1.82% increase, V-scale: .60% reduction). Sex had a statistically significant effect on CSA. Normalization methods based on canal area and skull volume reduced the CSA intersubject variability up to 16.84%. CONCLUSIONS: We present CSA normative values in a large cohort of children, reporting on sources of intersubject variability and how to reduce them applying normalization methods previously developed.

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Section: Resultssupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

MRI Measurement of Upper Cervical Spinal Cord Cross‐Sectional Area in Children

Papinutto

Cordano

Asteggiano

et al. 2020

Journal of Neuroimaging

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“…Compared to former analyses of reliability of other automated spinal cord segmentation tools, the ICC of spinal cord CSA at C6/C7 is currently lower than previously reported (e.g. ( Papinutto and Henry, 2019 , De Leener et al, 2015 ). As the ICC improved tremendously after exclusion of one outlier, we suspect the low inter-rater agreement to be caused by the manual labeling process.…”

Section: Discussioncontrasting

confidence: 60%

Focal cervical spinal stenosis causes mechanical strain on the entire cervical spinal cord tissue – A prospective controlled, matched-pair analysis based on phase-contrast MRI

Wolf

Reisert

Beltrán

et al. 2021

NeuroImage: Clinical

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“…Currently, there are some pipelines available for SC segmentation, 18,19 but we chose the SCT because it is highly reproducible and less affected by artifacts. [12][13][14] Then, we were able to show, for the first time, that cervical SC atrophy is found in some but not all HSP subtypes. Moreover, SC morphometric changes in HSP-SPG4 and SPG11 extend to both GM and WM.…”

Section: Discussionmentioning

confidence: 72%

“…13 This pipeline has high segmentation accuracy and acceptable intra-and interscanner reliability. 13,14 The measurement of these segmented structures can contribute to identifying potential biomarkers for HSPs through understanding the pattern of SC damage. This might be helpful for diagnostic purposes and also to assess disease progression.…”

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confidence: 99%

Spinal Cord Gray and White Matter Damage in Different Hereditary Spastic Paraplegia Subtypes

Servelhere

Casseb

Lima

et al. 2021

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE: Spinal cord damage is a hallmark of hereditary spastic paraplegias, but it is still not clear whether specific subtypes of the disease have distinctive patterns of spinal cord gray (GM) and white (WM) matter involvement. We compared cervical cross-sectional GM and WM areas in patients with distinct hereditary spastic paraplegia subtypes. We also assessed whether these metrics correlated with clinical parameters. MATERIALS AND METHODS:We analyzed 37 patients (17 men; mean age, 47.3 [SD, 16.5] years) and 21 healthy controls (7 men; mean age, 42.3 [SD, 13.2] years). There were 7 patients with spastic paraplegia type 3A (SPG3A), 12 with SPG4, 10 with SPG7, and 8 with SPG11. Image acquisition was performed on a 3T MR imaging scanner, and T2*-weighted 2D images were assessed by the Spinal Cord Toolbox. Statistical analyses were performed in SPSS using nonparametric tests and false discovery rate-corrected P values , .05. RESULTS:The mean disease duration for the hereditary spastic paraplegia group was 22.4 [SD, 13.8] years and the mean Spastic Paraplegia Rating Scale score was 22.8 [SD, 11.0]. We failed to identify spinal cord atrophy in SPG3A and SPG7. In contrast, we found abnormalities in patients with SPG4 and SPG11. Both subtypes had spinal cord GM and WM atrophy. SPG4 showed a strong inverse correlation between GM area and disease duration (r ¼ -0.903, P , .001).

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Evaluation of Intra‐ and Interscanner Reliability of MRI Protocols for Spinal Cord Gray Matter and Total Cross‐Sectional Area Measurements

Abstract: 1 Technical Efficacy: Stage 4.

Cited by 21 publications

References 33 publications

MRI Measurement of Upper Cervical Spinal Cord Cross‐Sectional Area in Children

MRI Measurement of Upper Cervical Spinal Cord Cross‐Sectional Area in Children

Focal cervical spinal stenosis causes mechanical strain on the entire cervical spinal cord tissue – A prospective controlled, matched-pair analysis based on phase-contrast MRI

Spinal Cord Gray and White Matter Damage in Different Hereditary Spastic Paraplegia Subtypes

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