Evaluation of Intoxication Cases Followed in Our Pediatric Intensive Care Unit

Yöntem, Ahmet; Yıldızdaş, Dinçer; Horoz, Özden Özgür; Ekinci, Faruk; Mısırlıoğlu, Merve; Bilen, Sevcan; Yılmaz, Hayri Levent

doi:10.4274/cayd.galenos.2020.97658

Cited by 2 publications

(4 citation statements)

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“…Poisoning cases can be hospitalized in the PICU for close monitoring, even if there is no system involvement at the time of admission. Studies conducted in our country and around the world have reported that 70% to 80% of patients hospitalized in the PICU due to poisoning do not require any treatment 15,26 . In our study, it was noted that 35.5% of the patients were given specific treatment, antidote treatment was the most common, and N -acetylcysteine was the most common antidote treatment.…”

Section: Discussionmentioning

confidence: 50%

“…Studies conducted in our country and around the world have reported that 70% to 80% of patients hospitalized in the PICU due to poisoning do not require any treatment. 15,26 In our study, it was noted that 35.5% of the patients were given specific treatment, antidote treatment was the most common, and Nacetylcysteine was the most common antidote treatment. Ozkale and Ozkale 10 reported that 26.5% of the patients were given specific treatment in their study, and N-acetylcysteine was the most common antidote treatment.…”

Section: Discussionmentioning

confidence: 67%

“…Most of the poisonings seen in childhood (85%-90%) are accidental, and 10%-15% of them are suicidal poisonings. 12,13 Some studies have reported that accidental poisonings are more common in boys, 14,15 and suicidal poisonings are more common in girls starting from adolescence. 16,17 We determined that 79.6% of the patients were poisoned by accident and 20.4% of them were poisoned by suicide.…”

Section: Discussionmentioning

confidence: 99%

“…Poisoning cases can be hospitalized in the PICU for close follow-up even if there is no system involvement at the time of admission 15 . In previous studies, it was reported that 28.7% to 34.5% of the patients were symptomatic, and the most common symptoms were reported to be related to GIS, followed by CNS 22,27–29 .…”

Section: Discussionmentioning

confidence: 99%

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Retrospective Evaluation of Poisoning Cases Followed Up in Pediatric Intensive Care Unit—A 12-Year Experience in a Single Center

Boyraz,

Botan,

Yuce

et al. 2023

Pediatr Emer Care

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Objectives Poisonings constitute an important part of preventable morbidity and mortality in pediatric intensive care units (PICUs) and hospitalizations. However, information on poisoning requiring intensive care is limited. This study aimed epidemiological evaluation of poisoning cases treated in the PICU in a single center. Methods The records of 504 patients admitted to the PICU due to acute poisoning between 2010 and 2022 were retrospectively reviewed. Data were evaluated using descriptive methods and the χ2 test, and statistical differences with P value <0.05 were considered significant. Results The age range of the patients ranged from 1 month to 216 months (18 years), and the rate of girls was 53.2% (n = 268), whereas the rate of boys was 46.8% (n = 236). The mean age was 4.4 ± 4.3 years for boys, 6.7 ± 5.8 years for girls, and 5.6 ± 5.3 years for all patients. It was determined that 79.6% of the cases were poisoned by accident and 20.4% by suicide. A total of 76.7% of the patients who were poisoned for suicide were girls and 23.3% were boys. The mean age of these patients was 14.3 ± 3.0 years. On the other hand, 47.1% of the children who were accidentally poisoned were girls and 52.9% were boys, and the mean age of these children was 3.4 ± 2.9 years. Although 79.9% of poisonings occurred at home, the causative agent was oral poisoning in 97.4% of the cases. Approximately two thirds (69.2%) of the cases were drug-related, whereas 30.8% were related to nondrug substances. In drug-related poisonings, central nervous system drugs (35.8%) were the most common agent, followed by analgesic/antipyretic (20.9%) agents, whereas among the nonpharmaceutical factors, insecticides (agricultural pesticides, rat poison, pesticides, etc) were the most common, followed by poisonous herbs (beetleweed, widow's weed, cannabis, etc). The mean admission time of the patients to the hospital was 6.3 ± 8.4 hours, and the mean length of stay in the intensive care unit was 1.6 ± 1.3 days. In the 12 years of our study, only 3 patients died due to poisoning, and our mortality rate was 0.5%. Four patients (0.7%) were referred to the Alcohol and Drug Addicts Treatment and Research Center. Conclusions In this study, in which we retrospectively analyzed the profiles of poisoning cases hospitalized in the PICU for 12 years, we determined that poisonous weeds were the major factor in accidental poisonings, and suicidal poisonings were above the expected rates even at the young age group such as 8–12 years old. These results show the importance of determining the poisoning profile of the health care service area.

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Section: Discussionmentioning

confidence: 50%

Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Retrospective Evaluation of Poisoning Cases Followed Up in Pediatric Intensive Care Unit—A 12-Year Experience in a Single Center

Boyraz,

Botan,

Yuce

et al. 2023

Pediatr Emer Care

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Life-threatening amlodipine and irbesartan poisoning in two adolescents: Extracorporeal life support is life-saving

Koç,

Ersayoğlu,

Cebeci

et al. 2024

Trends in Pediatrics

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Calcium channel blockers (CCBs’) and angiotensin receptor blockers (ARBs’) are widely used in clinical practice and are easily available. Intoxication with these drugs results in life-threatening deep vasoplegic shock, making them particularly dangerous, especially for children. Here, we report two patients who ingested amlodipine and irbesartan for suicidal attempts and were unresponsive to all conventional treatments. They were placed on venoarterial extracorporeal membrane oxygenation (VA-ECMO) and hemodynamically stable immediately after extracorporeal life support (ECLS). Patients were successfully decannulated and extubated. CCB and ARB poisoning that are resistant to medical therapy can be treated by ECLS successfully.

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Evaluation of Intoxication Cases Followed in Our Pediatric Intensive Care Unit

Cited by 2 publications

References 0 publications

Retrospective Evaluation of Poisoning Cases Followed Up in Pediatric Intensive Care Unit—A 12-Year Experience in a Single Center

Retrospective Evaluation of Poisoning Cases Followed Up in Pediatric Intensive Care Unit—A 12-Year Experience in a Single Center

Life-threatening amlodipine and irbesartan poisoning in two adolescents: Extracorporeal life support is life-saving

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