Evaluation of interstitial lung disease in mixed connective tissue disease (MCTD)

Abstract

HRCT is the gold standard for diagnosis of ILD. However, we used another method, (99m)Tc-DTPA, in order to compare this technique with HRCT. This latter technique has not been studied previously in MCTD. The elevated levels of IC and increased complement consumption indicated that IC-mediated alveolocapillary membrane damage and tissue injury might play a role in the pathogenesis of ILD in MCTD.

Pictorial review: Thoracic involvement in connective tissue diseases: radiological patterns and follow-up

“…Pulmonary hemorrhage, diffuse alveolar damage, organizing pneumonia, NSIP, UIP, airway disease may be seen in these patients (35). This is consistent with the other manifestations of MCTD which have features of PSS, SLE or PM/DM.…”

Rheumatoid Arthritis-Associated Interstitial Lung Disease

“…Interstitial lung disease (ILD) is the primary pulmonary manifestation of RA, as it is for other connective tissue diseases (CTDs), such as scleroderma (systemic sclerosis), inflammatory myositis (polymyositis and dermatomyositis), Sjö gren syndrome, and undifferentiated CTD. [2][3][4][5][6][7] RA-associated ILD (RA-ILD) is a source of substantial morbidity and mortality for affected patients. The histopathologic and radiographic appearance of RA-ILD is heterogeneous and primarily mimics the following two patterns seen in the idiopathic interstitial pneumonias (IIPs): usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP) [Fig 1].…”

Treatment of pulmonary fibrosis for twenty weeks with imatinib mesylate in a patient with mixed connective tissue disease

“…Later, a high prevalence of arthritis resembling rheumatoid arthritis was observed in patients with MCTD. Pulmonary involvement is commonly observed in patients with MCTD (2)(3)(4)(5)(6). The prevalence of interstitial lung disease has been suggested to be as high as 67%, based on findings of high-resolution computed tomography (HRCT) and gadolinium diethylenetriaminepentaacetic acid scans.…”

“…The prevalence of interstitial lung disease has been suggested to be as high as 67%, based on findings of high-resolution computed tomography (HRCT) and gadolinium diethylenetriaminepentaacetic acid scans. Ground-glass opacities were found in 48-78% of patients by HRCT (3,4). Although many of these patients are asymptomatic, interstitial lung disease can progress to severe, lifethreatening lung fibrosis in patients with MCTD.…”