Background:
Several compounds have been synthesized as a therapeutic alternative for heart failure; however, its
preparation requires special conditions.
Objective:
The aim of this study, was to synthesize some aniline derivatives (4-9) from 3-ethynylaniline to evaluate their
biological activity against heart failure.
Methods:
The synthesis of aniline derivatives involved a series of reactions such as etherification, addition, and cyclization.
The structure of all compounds obtained was confirmed by spectroscopic and spectrometric methods. In addition, to evaluate
the biological activity of compounds an ischemia/reperfusion injury model was used.
Results:
The results showed that compound 8 decreases heart failure, which translates into a decrease in the infarction area
compared to compounds 4-7 and 9.
Conclusion:
This study is reported a facile method for the preparation of aniline derivatives. This method offers some
advantages such as; a simple procedure, low cost, and ease of work. In addition, compound 8 showed an interesting biological
activity against heart failure. This phenomenon is particularly interesting because the biological activity induced by this
compound could involve a molecular mechanism different compared with other drugs used for the treatment of heart failure.