Evaluation of innovative polyvinyl alcohol/ alginate/ green palladium nanoparticles composite scaffolds: Effect on differentiated human dental pulp stem cells into osteoblasts

Ismail, Enas; Mabrouk, Mostafa; Salem, Zeinab A.; AbuBakr, Nermeen; Beherei, Hanan H.

doi:10.1016/j.jmbbm.2023.105700

Cited by 3 publications

(2 citation statements)

References 48 publications

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“…Ismail et al developed an innovative polyvinyl alcohol/ALG (PVA/Alg) composite scaffold loaded with green-synthesized Pd NPs. Their results suggested the loading with Pd NPs provides an appropriate mechanical support, increases cell viability, and produces an extracellular and mineralized matrix [185]. Murugesan et al investigated the effects of Pd NPs on nanocomposite scaffolds composed of reduced graphene oxide (rGO) functionalized with polypyrrole (PPy) (Pd/PPy/rGO).…”

Section: Metal Npsmentioning

confidence: 99%

Bone Tissue Engineering and Nanotechnology: A Promising Combination for Bone Regeneration

Bauso,

La Fauci,

Longo

et al. 2024

Biology

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Large bone defects are the leading contributor to disability worldwide, affecting approximately 1.71 billion people. Conventional bone graft treatments show several disadvantages that negatively impact their therapeutic outcomes and limit their clinical practice. Therefore, much effort has been made to devise new and more effective approaches. In this context, bone tissue engineering (BTE), involving the use of biomaterials which are able to mimic the natural architecture of bone, has emerged as a key strategy for the regeneration of large defects. However, although different types of biomaterials for bone regeneration have been developed and investigated, to date, none of them has been able to completely fulfill the requirements of an ideal implantable material. In this context, in recent years, the field of nanotechnology and the application of nanomaterials to regenerative medicine have gained significant attention from researchers. Nanotechnology has revolutionized the BTE field due to the possibility of generating nanoengineered particles that are able to overcome the current limitations in regenerative strategies, including reduced cell proliferation and differentiation, the inadequate mechanical strength of biomaterials, and poor production of extrinsic factors which are necessary for efficient osteogenesis. In this review, we report on the latest in vitro and in vivo studies on the impact of nanotechnology in the field of BTE, focusing on the effects of nanoparticles on the properties of cells and the use of biomaterials for bone regeneration.

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Section: Metal Npsmentioning

confidence: 99%

Bone Tissue Engineering and Nanotechnology: A Promising Combination for Bone Regeneration

Bauso,

La Fauci,

Longo

et al. 2024

Biology

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“…It was found that this DPSC-secreted ECM enhanced the integration of artificial bone constructs and induced successful tissue regeneration. Ismail et al [ 46 ] improved the innovative composite scaffolds for dental applications, specifically bone tissue engineering, using palladium nanoparticles (Pd NPs), a hybrid material containing polyvinyl alcohol and alginate. The scaffolds showed impressive microstructure, shape stability, and oriented lamellar porosity.…”

Section: Scaffold Application In Bone Regeneration With Stem Cellsmentioning

confidence: 99%

Scaffold Application for Bone Regeneration with Stem Cells in Dentistry: Literature Review

Saberian,

Jenča,

Zafari

et al. 2024

Cells

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Bone tissue injuries within oral and dental contexts often present considerable challenges because traditional treatments may not be able to fully restore lost or damaged bone tissue. Novel approaches involving stem cells and targeted 3D scaffolds have been investigated in the search for workable solutions. The use of scaffolds in stem cell-assisted bone regeneration is a crucial component of tissue engineering techniques designed to overcome the drawbacks of traditional bone grafts. This study provides a detailed review of scaffold applications for bone regeneration with stem cells in dentistry. This review focuses on scaffolds and stem cells while covering a broad range of studies explaining bone regeneration in dentistry through the presentation of studies conducted in this field. The role of different stem cells in regenerative medicine is covered in great detail in the reviewed literature. These studies have addressed a wide range of subjects, including the effects of platelet concentrates during dental surgery or specific combinations, such as human dental pulp stem cells with scaffolds for animal model bone regeneration, to promote bone regeneration in animal models. Noting developments, research works consider methods to improve vascularization and explore the use of 3D-printed scaffolds, secretome applications, mesenchymal stem cells, and biomaterials for oral bone tissue regeneration. This thorough assessment outlines possible developments within these crucial regenerative dentistry cycles and provides insights and suggestions for additional study. Furthermore, alternative creative methods for regenerating bone tissue include biophysical stimuli, mechanical stimulation, magnetic field therapy, laser therapy, nutritional supplements and diet, gene therapy, and biomimetic materials. These innovative approaches offer promising avenues for future research and development in the field of bone tissue regeneration in dentistry.

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Recent advancements in hydrogels as novel tissue engineering scaffolds for dental pulp regeneration

Guo,

Li,

et al. 2024

International Journal of Biological Macromolecules

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Evaluation of innovative polyvinyl alcohol/ alginate/ green palladium nanoparticles composite scaffolds: Effect on differentiated human dental pulp stem cells into osteoblasts

Cited by 3 publications

References 48 publications

Bone Tissue Engineering and Nanotechnology: A Promising Combination for Bone Regeneration

Bone Tissue Engineering and Nanotechnology: A Promising Combination for Bone Regeneration

Scaffold Application for Bone Regeneration with Stem Cells in Dentistry: Literature Review

Recent advancements in hydrogels as novel tissue engineering scaffolds for dental pulp regeneration

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