Evaluation of information flows in the RAS-MAPK system using transfer entropy measurements
Nobuhisa Umeki,
Yoshiyuki Kabashima,
Yasushi Sako
Abstract:The RAS-MAPK system serves as a prominent signal processing network within animal cells, controlling various cell fates such as proliferation, differentiation, and cell death. Dysregulation of this system has been identified in genetic diseases and cancer affecting diverse tissues. To better understand the dynamics of this system, we employed information flow analysis based on transfer entropy (TE) between the activation dynamics of two key elements: SOS, a guanine nucleotide exchanger for the small GTPase RAS… Show more
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