Evaluation of Inflammatory Markers in Pregnant Women at Risk, for the Prediction of Preeclampsia

Abstract

Introduction:A low degree of infl ammation has been associated with complications in pregnancies, including preeclampsia (PE). The aim of our study was to determine the serum values of high sensitivity C Reactive Protein (hs-CRP) and Interleukin-6 (IL-6) in the fi rst and second trimesters of pregnancy in pregnant women with risk factors for the development of PE, and to evaluate their relevance for the prediction of this disorder. Material and methods:We performed a prospective longitudinal study on 120 pregnant women, who were divided based on the pregnancy evolution, into two groups: group I -26 pregnant women who developed preeclampsia and group II -94 pregnant women with physiological evolution of pregnancy. Results: Our study has shown an increase in serum levels of hs-CRP and IL-6 in the fi rst and second trimester of pregnancy in patients from group I, signifi cant values being revealed only in the second trimester of pregnancy. The predictive power of the selected infl ammatory markers was signifi cant only for values of hs-CRP in the second trimester of pregnancy, while the association with IL-6 increased the prediction. Conclusions: Increased values of hs-CRP and IL-6 in the second trimester of pregnancy are associated with higher risk for preeclampsia, however the study provided only a modest effi ciency of the prediction capacity.

Association of lipoprotein (a) and high-sensitive C-reactive protein in preeclampsia

“…(Table 2) These results are comparable with the studies conducted elsewhere [11][12][13] . Patho-physiologically, the hallmark of preeclampsia includes increased vasoconstriction resulting in maternal hypertension and reduced uteroplacental blood flow, disturbed vascular endothelial integrity with increased vascular permeability, and activation of the coagulation cascade [5,7,13,14] . Inflammatory cells are activated in preeclampsia and localized to the site of vascular injury and associated with higher levels of pro-inflammatory molecules, cytokines and adhesion molecules [5,7,13,14] .…”

“…Patho-physiologically, the hallmark of preeclampsia includes increased vasoconstriction resulting in maternal hypertension and reduced uteroplacental blood flow, disturbed vascular endothelial integrity with increased vascular permeability, and activation of the coagulation cascade [5,7,13,14] . Inflammatory cells are activated in preeclampsia and localized to the site of vascular injury and associated with higher levels of pro-inflammatory molecules, cytokines and adhesion molecules [5,7,13,14] . In the present study, the average lipoprotein (a) levels were significantly higher among preeclamptic group (43.25±12.3 mg/dl) compared to normal pregnancy group 23.75±5.43mg/dl).…”

Artikel Review : Sistem Imunitas Dalam Kehamilan

“…preeklampsia, dan sindrom kehamilan lainnya (Romero et al, 2008). terjadinya preeklamsia, tetapi nilai prediksinya masih ambigu (Daniela et al, 2014).…”