Evaluation of inflammatory markers in threatened abortions and spontaneous abortions

Taşkömür, Aysun Tekeli; Aydın, Sakine Merve

doi:10.5603/gp.a2022.0069

Cited by 1 publication

(2 citation statements)

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“…24 Similarly, another retrospective study of 39 pregnant women with missed abortion and 239 normal healthy pregnant women reported high serum NLR rates in favor of missed abortion, while no significant difference was found in serum PLR values. 25 The pregnant groups in both those studies differed from those in the present research, and it is unclear whether these increased serum NLR and PLR values cause miscarriage, or whether that elevation is a result of miscarriage, in other words, whether they represent a cause or an effect. A previous study of 60 pregnant women with threatened miscarriage, 60 aborting pregnant women, and 60 healthy pregnant individuals reported significantly higher serum NLR values in the women with threatened miscarriage than in the other two groups, while no difference was detected in serum PLR values between the groups.…”

Section: Gestational Age On Admission (Week)contrasting

confidence: 68%

“…A study comparing 40 pregnant women with missed abortion and 40 healthy pregnant women reported significantly higher maternal serum NLR and PLR values in cases of missed abortion 24 . Similarly, another retrospective study of 39 pregnant women with missed abortion and 239 normal healthy pregnant women reported high serum NLR rates in favor of missed abortion, while no significant difference was found in serum PLR values 25 . The pregnant groups in both those studies differed from those in the present research, and it is unclear whether these increased serum NLR and PLR values cause miscarriage, or whether that elevation is a result of miscarriage, in other words, whether they represent a cause or an effect.…”

Section: Discussionmentioning

confidence: 96%

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An evaluation of serum blood parameters and amyloid A levels in pregnant women with threatened miscarriage

Isenlik,

Sarica,

Kaygun

et al. 2024

American J Rep Immunol

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ObjectiveThis study investigated whether serum amyloid A (AA) levels can be used as a biomarker in patients with threatened abortion.Material and MethodsThis prospective cohort study was conducted at the Antalya Training and Research Hospital, Department of Obstetrics and Gynecology, Türkiye, between April and October 2023. Eighty‐eight pregnant women, 44 diagnosed with threatened miscarriage (Group 1) and 44 healthy individuals (Group 2), were included in the study. Sociodemographic, obstetric, and laboratory parameters were compared between the groups.ResultsNo statistically significant differences were observed between the groups in terms of sociodemographic data (age, body mass index, education level, economic status, occupation status, smoking, and alcohol consumption). However, obstetric characteristics (number of pregnancies, living children, miscarriages, dilatation and curettage, gestational age on admission, and fetal crown‐rump length) and laboratory values including complete blood count, hematocrit, leukocyte, neutrophil, lymphocytes, platelet, hs‐C‐reactive protein, neutrophil‐lymphocyte and platelet‐lymphocyte ratio (p > .05), and serum AA values (7.49 ± 3.07 in Group 1 vs. 9.46 ± 4.80 in Group 2, p = .024) differed significantly. Receiver operating characteristic analysis showed that the area under the curve (AUC: 0.662) was statistically significant for serum AA (p = .032), with a cut‐off value of ≥7.51 (95% [confidence interval] 0.516−0.749, sensitivity 65%, specificity 51%). The positive predictive value of serum AA for threatened miscarriage was 56.8%, and the negative predictive value 59.4%.ConclusionThis study shows that serum AA can be used as a biomarker in the diagnosis of threatened miscarriage. Prospective studies involving more participants are now needed to confirm our results.

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Section: Gestational Age On Admission (Week)contrasting

confidence: 68%

Section: Discussionmentioning

confidence: 96%

An evaluation of serum blood parameters and amyloid A levels in pregnant women with threatened miscarriage

Isenlik,

Sarica,

Kaygun

et al. 2024

American J Rep Immunol

View full text Add to dashboard Cite

show abstract

Evaluation of inflammatory markers in threatened abortions and spontaneous abortions

Abstract: This article has been peer reviewed and published immediately upon acceptance.It is an open access article, which means that it can be downloaded, printed, and distributed freely, provided the work is properly cited. Articles in "Ginekologia Polska" are listed in PubMed.

Cited by 1 publication

References 10 publications

An evaluation of serum blood parameters and amyloid A levels in pregnant women with threatened miscarriage

An evaluation of serum blood parameters and amyloid A levels in pregnant women with threatened miscarriage

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