Evaluation of Inflammation and Oxidative Stress Markers in Patients with Obstructive Sleep Apnea (OSA)

Abstract

Background: The identification of circulating markers of oxidative stress and systemic inflammation might enhance risk stratification in obstructive sleep apnea (OSA). We investigated the association between specific haematological parameters, as easily measurable markers of oxidative stress and inflammation, and the degree of hypoxia during polysomnography using the apnea hypopnea index (AHI), oxygen desaturation index (ODI), and oxygen saturation (SpO2), in OSA patients. Methods: Associations between polysomnographic parameters and demographic, clinical, and laboratory characteristics were assessed in a consecutive series of patients with OSA attending the Respiratory Disease Unit of the University Hospital of Sassari, north Sardinia (Italy), between 2015 and 2019. Results: In 259 OSA patients (195 males and 64 females), the body mass index (BMI) was significantly and positively associated with the AHI and ODI, and negatively associated with the mean SpO2. No haematological parameter was independently associated with the AHI or ODI. By contrast, albumin, neutrophil, and monocyte counts, and the systemic inflammatory response index (SIRI) were independently associated with a lower SpO2. Conclusions: Our results suggest that albumin and specific haematological parameters are promising markers of reduced oxygen saturation in OSA.

Causal Relationships Between Circulating Inflammatory Proteins and Obstructive Sleep Apnea: A Bidirectional Mendelian Randomization Study

“…For forward MR, we identified independent genetic variants in CIPs that reached genome-wide significance (p < 5×10⁻ 8 ), ie SNPs. However, the initial SNP selection using this criterion demonstrated limitations.…”

“…However, the initial SNP selection using this criterion demonstrated limitations. Previous studies indicate the challenge of attaining the gold standard threshold of p < 5×10⁻ 8 for SNP selection in certain non-disease-related human phenotypes, such as gut microbiota, metabolic products, and immunological characteristics. Thus, for present MR analysis, setting the threshold between 5×10⁻⁶ and 5×10⁻⁵ is feasible.…”

“… 7 A separate study exploring the relationship between specific hematological and polysomnographic parameters in OSA patients revealed independent associations between albumin, neutrophil, and monocyte counts, as well as the systemic inflammation response index (SIRI), with reduced oxygen saturation levels in OSA patients. 8 …”

“…7 A separate study exploring the relationship between specific hematological and polysomnographic parameters in OSA patients revealed independent associations between albumin, neutrophil, and monocyte counts, as well as the systemic inflammation response index (SIRI), with reduced oxygen saturation levels in OSA patients. 8 Mendelian randomization (MR) is a modern research methodology that utilizes genetic variations strongly linked to exposure factors as instrumental variables (IVs). It aims to infer causal relationships between exposure and outcome.…”

High Monocyte-to-Lymphocyte Ratio is Associated with Obstructive Sleep Apnea Hypopnea Syndrome

“…Studies have shown that NLR is associated with the severity of OSAHS. 23 Some research has investigated the relevance of SII and SIRI in the development of OSAHS 24,25 . However, there is currently no reported research on the relationship between MLR, PIV, and the occurrence of OSAHS, nor comparative studies of the association between different inflammatory parameters and the development of OSAHS.…”