Evaluation of infiltrative growth pattern in squamous cell carcinoma of the tongue: Comparison with Yamamoto–Kohama classification

Abstract

博士（歯学）・第２１１２号（甲 第1325号）・平成２７年３月３１日学術雑誌投稿済み論文による学位審査のため、本文(出版社版)登録不可。よって、著者最終稿を要約として登録

A retrospective investigation of minor risk factors as prognostic predictors and treatment indications in oral squamous cell carcinoma

“… 18 Our results are consistent with those of previous studies. 14 , 18 However, the criteria used to determine a tumor's YK classification, and especially grade 4C/4D invasion, vary markedly among pathologists, which might have affected our results. 19 …”

“… 17 On the other hand, in recent studies although 5-year disease-free survival was significantly lower in patients that exhibited grade 4C invasion than in those that displayed grade 1, 2, or 3 invasion, there was no significant difference in the survival rate between grades 4C and 4D. 18 Our results are consistent with those of previous studies. 14 , 18 However, the criteria used to determine a tumor's YK classification, and especially grade 4C/4D invasion, vary markedly among pathologists, which might have affected our results.…”

Tumor-stroma contact ratio - a novel predictive factor for tumor response to chemoradiotherapy in locally advanced oropharyngeal cancer

“…Extensive in vivo data from human carcinomas demonstrates the critical role the activated tumor stroma plays in tumor growth and treatment response. In particular, the pattern of tumor invasion, driven by interactions between malignant epithelial cells and activated fibroblasts, creates particular tumor microenvironments (TME) and reflects the invasive potential of squamous cell carcinomas (SCC) of the head and neck region [ [4] , [5] , [6] , [7] , [8] , [11] , [12] , [13] , [14] ]. Hence, it would be desirable to have an objective, reproducible and quantitative measure representing the shape of the tumor-stroma interface to enable correlation with other pathological characteristics of the tumor (e.g., biomarker expression or immune cell composition) and clinical outcome data.…”

“…While data on the pattern of invasion in OPSCC is sparse, extensive evidence from squamous cell carcinomas of the oral cavity (OSCC) demonstrates that invasive growth patterns at the tumor-host border are associated with poorer outcomes, higher metastatic risk, and reduced survival [ [4] , [5] , [6] , [7] , [8] , [9] ]. Consequently, risk stratification scores incorporating invasion patterns have been proposed to guide adjuvant radiotherapy decisions in OSCC [ 3 , 4 ].…”

Effect of chloroquine on the apoptosis of tongue squamous cell carcinoma SCC25 cells induced by bleomycin and nedaplatin

“…Chemotherapy, as one of the important methods for treating tongue cancer, is crucial for the treatment of advanced cases, auxiliary before and after surgery and some patients with distant metastasis, and can effectively improve the prognosis of patients. However, conventional chemotherapy drugs at present are easy to cause a series of side effects [5][6][7][8][9] such as loss of appetite, alopecia, vomiting, nausea, body immunity decline, bone marrow suppression, etc. At present, scholars at home and abroad believe that the combination of drugs can effectively improve the curative effect of tumor and survival rate of patients, but these treatments often increase drug toxicity and cause the risk of cross drug resistance [10][11] .…”