Evaluation of Infiltration of Immunological cells (Tumour Associated Tissue Eosinophils and Mast cells) in Oral Squamous Cell Carcinoma by Using Special Stains

Debta, Priyanka; Debta, Fakir Mohan; Chaudhary, Minal; Dani, Anurag

doi:10.9734/bjmmr/2012/680

Cited by 7 publications

(9 citation statements)

References 37 publications

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“…Thus, a controversy still exists. [ 18 ] Till now, there are only few literature [ 18 19 20 ] in which both myeloid cells (Tumor-associated tissue eosinophils [TATE] and mast cells) has been observed in the OSCC. Hence, in search of new predictive factors for OSCC, our study aimed to evaluate the significance of tissue eosinophil and mast cell infiltration in different grades (WHO grading) of OSCC.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of myeloid cells (tumor-associated tissue eosinophils and mast cells) infiltration in different grades of oral squamous cell carcinoma

Debta

Chaudhary³

et al. 2016

Indian Journal of Medical and Paediatric Oncology

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Background:The multifunctional involvement and infiltration of myeloid cells (tumor-associated tissue eosinophils [TATE] and mast cells) can provide a unique opportunity to define relevant effectors functions that may represent novel, therapeutic options for modulation of tumor onset/growth.Aim:Our study aimed to evaluate infiltration of myeloid cells (TATE and Mast cells) infiltration in different grades (WHO grading) of oral squamous cell carcinoma (OSCC).Materials and Methods:Total 30 cases of OSCC were selected for this study. Hematoxylin and eosin stain and toluidine blue special stain, to evaluate TATE and the mast cells infiltration, were used. Three-year follow-up of OSCC cases was done.Result:Among 30 cases, 63.33% cases of OSCC showed TATE-positive and 36.66% cases showed TATE-negative. Regarding mast cells infiltration, 66.66% OSCC cases showed mast cells positive and 33.33% cases did not show significant mast cells infiltration. We found significant association of TATE and mast cells infiltration in OSCC cases. These myeloid cells infiltration significantly associated with age of patients but did not show any significant association with gender, site, and habit of cases. When we compared these cells infiltration with clinical stages and different histological grades of tumor, we found their infiltration is decreasing, from Stages 1 to Stage 3 of tumor and from well to poorly differentiated carcinoma. We have also found the less infiltration of these myeloid in recurrence cases of OSCC.Conclusion:As the infiltration of TATE and mast cells are correlated, along with evaluation of TATE, we should also evaluate the presence of mast cells infiltration in OSCC. The assessment of myeloid cells could become, in the future, useful for therapeutic approaches in this subset of the patient.

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Section: Introductionmentioning

confidence: 99%

Evaluation of myeloid cells (tumor-associated tissue eosinophils and mast cells) infiltration in different grades of oral squamous cell carcinoma

Debta

Chaudhary³

et al. 2016

Indian Journal of Medical and Paediatric Oncology

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“…It is characterised by the presence of eosinophils as a component of peritumoral and intratumoral inflammatory infiltrate [ 7 , 8 ]. TATE in malignancies is associated with different sites such as nasopharynx [ 6 , 9 ], larynx [ 10 , 11 ], esophagus [ 12 ], colon [ 13 , 14 ], cervix [ 15 ], external genitalia [ 16 ], skin [ 17 ], gastrointestinal tract [ 18 ], and oral cavity [ 7 , 8 , 16 , 19 – 27 ].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Tissue Eosinophilia as a Prognosticator in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma—An Image Analysis Study

Jain

Kasetty

Sudheendra

et al. 2014

Pathology Research International

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Association of tissue eosinophilia with oral squamous cell carcinoma has shown variable results ranging from favourable to unfavourable or even having no influence on prognosis. Also, very few studies have been done to know the role of eosinophils in premalignancy. So the present study investigated role of eosinophilic infiltration in oral precancer and cancer and its possible use as a prognosticator. 60 histopathologically proven cases (20 cases each of metastatic and nonmetastatic oral squamous cell carcinoma and oral leukoplakia with dysplasia of various grades) were included. Congo red is used as a special stain for eosinophils. Each specimen slide was viewed under high power in 10 consecutive microscopic fields for counting of eosinophils. As a result, a significant increase in eosinophil count was found in oral carcinomas compared to dysplasia. Nonmetastatic cases showed higher counts than metastatic carcinomas. So, it is concluded that eosinophilia is a favourable histopathological prognostic factor in oral cancer. Moreover, higher eosinophil counts in carcinoma group compared to dysplasia group proved that they might have a role in stromal invasion thus suggesting that quantitative assessment of tissue eosinophilia should become a part of the routine histopathological diagnosis for oral precancer and OSCC.

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“…[11] Stromal response usually characterized by the intensity of lymphoplasmacytic infiltration surrounding the tumor plays a decisive role in tumor initiation, progression, and metastasis. [8,12] Increase in the number of eosinophils above 450/cu mm is regarded as eosinophilia. It is often produced as response rather than the actual disease process.…”

Section: Discussionmentioning

confidence: 99%

Tumor-associated tissue eosinophilia in oral squamous cell carcinoma – A predictable biological behavior

Shrestha

Narayan

Kumar

et al. 2020

JGOH

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Objectives: Squamous cell carcinoma of the oral cavity is the most common aggressive epithelial malignant neoplasm. Its biological behavior is influenced by the host immune cells, such as multifaceted eosinophils, associated with wound healing and tissue damage processes. Their presence within a variety of human cancers raises queries about their role. The infiltrations of tumor stroma by eosinophils are believed to play a significant role in progression of the carcinoma and could be either a potential diagnostic tool for stromal invasion or as a prognostic indicator. Its role in cancer still remains unclear since in the literature, there are very few studies showing improved prognosis and few contradictory studies showing poor prognosis. This study was conducted with an aim to compare the tumor-associated tissue eosinophilia in oral squamous cell carcinoma (OSCC) and normal tissue and to correlate the expression in different grades of carcinoma using a special stain that targets eosinophils exclusively and vividly. Materials and Methods: The study includes 30 samples, six normal, and 24 histopathologically diagnosed with OSCC. 5 μ thick sections were made and stained using special stain and examined under high power (×40), ten consecutive microscopic fields were studied. The average numbers of eosinophils were statistically analyzed. Results: Eosinophil count for carcinoma was higher compared to normal mucosa, but the comparison in different grades of cancer did not show much difference. Conclusion: Since eosinophil count was higher in carcinoma, eosinophil infiltration in dysplastic cases should prompt thorough evaluation for invasiveness.

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Evaluation of Infiltration of Immunological cells (Tumour Associated Tissue Eosinophils and Mast cells) in Oral Squamous Cell Carcinoma by Using Special Stains

Abstract: Aim: Our study aimed to evaluate the infiltration of tissue eosinophils and mast cells in oral squamous cell carcinoma (OSCC) by using special stains. Study Design: Comparative study.

Cited by 7 publications

References 37 publications

Evaluation of myeloid cells (tumor-associated tissue eosinophils and mast cells) infiltration in different grades of oral squamous cell carcinoma

Evaluation of myeloid cells (tumor-associated tissue eosinophils and mast cells) infiltration in different grades of oral squamous cell carcinoma

Assessment of Tissue Eosinophilia as a Prognosticator in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma—An Image Analysis Study

Tumor-associated tissue eosinophilia in oral squamous cell carcinoma – A predictable biological behavior

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