“…Thus, in the presence of unmeasured disturbances, inferential control is one of the solutions that can be used to control an unmeasured process output. Although, in distillation columns, the compositions are strong functions of temperatures (Kano et al, 2000), in multi-component distillation, temperature control is not always effective for composition control, since the tray temperature does not correspond exactly to the product compositions (Patke et al, 1982, Kano et al, 2000. Therefore, it is important to be able to infer compositions from secondary measurements like temperatures, flows, pressures, etc.…”