Evaluation of in vitro α-amylase and α-glucosidase inhibitory potential and hemolytic effect of phenolic enriched fractions of the aerial part of Salvia officinalis L.

Mahdi, Souad; Azzi, Rachid; Lahfa, Farid

doi:10.1016/j.dsx.2020.05.002

Cited by 12 publications

(7 citation statements)

References 25 publications

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“…In this study, hydroethanolic sage extract was shown to be an excellent α-glucosidase inhibitor, especially when compared to the aqueous one. Better activity of the sage extracts prepared using moderately polar solvents was also observed in the study of Mahdi et al [57]. In their study, the extract prepared using ethyl-acetate was better inhibitor of α-amylase and α-glucosidase than the extracts prepared using either hydro-methanol solution or n-butanol.…”

Section: The Relationship Between the Investigated Variablessupporting

confidence: 67%

“…Several studies have noted the abundance of phenolic compounds in sage extracts, connecting them to the potential antidiabetic effects of this plant [45]. Sage phenolics may affect carbohydrate digestion [57], inhibit hepatocyte gluconeogenesis, and decrease insulin resistance. In this study, hydroethanolic sage extract was shown to be an excellent α-glucosidase inhibitor, especially when compared to the aqueous one.…”

Section: The Relationship Between the Investigated Variablesmentioning

confidence: 99%

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Chemical Composition, Antioxidant, and α-Glucosidase-Inhibiting Activity of Aqueous and Hydroethanolic Extracts of Traditional Antidiabetics from Croatian Ethnomedicine

et al. 2021

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Type 2 diabetes (T2D) is a chronic disease with a growing prevalence worldwide. In addition to the conventional therapy, many T2D patients use phytotherapeutic preparations. In the present study, chemical composition, antioxidant, and α-glucosidase inhibiting activity of traditional antidiabetics from Croatian ethnomedicine (Achillea millefolium, Artemisia absinthium, Centaurium erythraea, Morusalba, Phaseolus vulgaris, Sambucus nigra, and Salvia officinalis) were assessed. The efficacy of water and 80% ethanol as extraction solvents for bioactive constituents was compared. HPLC analysis revealed that the prepared extracts were rich in phenols, especially rutin, ferulic, and chlorogenic acid. Antiradical (against DPPH and ABTS radicals), reducing (towards Mo6+ and Fe3+ ions), and enzyme inhibiting properties were in linear correlation with the content of phenolic constituents. Ethanolic extracts, richer in phenolic substances, showed dominant efficacy in those assays. Aqueous extracts, on the other hand, were better Fe2+ ion chelators and more active in the β-carotene linoleic acid assay. Extracts from S. officinalis and A. millefolium were particularly active antioxidants and α-glucosidase inhibitors. A. absinthium, another potent α-glucosidase inhibitor, contained chromium, a mineral that promotes insulin action. The investigated plants contained significant amounts of minerals useful in management of T2D, with negligible amounts of heavy metals deeming them safe for human use.

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Section: The Relationship Between the Investigated Variablessupporting

confidence: 67%

Section: The Relationship Between the Investigated Variablesmentioning

confidence: 99%

Chemical Composition, Antioxidant, and α-Glucosidase-Inhibiting Activity of Aqueous and Hydroethanolic Extracts of Traditional Antidiabetics from Croatian Ethnomedicine

et al. 2021

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“…On the other hand, the proportion of total phenols among tested Salvia extracts varied considerably (1–26%). Previous reports also indicate a great variability in the total phenolics (expressed as gallic acid equivalents) of Salvia extracts of various polarity as follows: S. officinalis (2–293 mg/g) [ 35 , 36 , 37 , 38 ], S. fruticosa (24–267 mg/g) [ 39 , 40 , 41 , 42 , 43 ], S. nemorosa (40–295 mg/g) [ 44 , 45 , 46 ], S. sclarea (30–268 mg/g) [ 41 , 42 , 44 , 47 , 48 ], and S. verticillata (50–176 mg/g) [ 46 , 47 , 49 ]. Contrary to the above, the total phenolics in different samples of S. glutinosa were quite similar (38–43 mg/g) [ 44 , 50 ].…”

Section: Resultsmentioning

confidence: 99%

“…Mocan et al [ 50 ] also found that these two species equally inhibited α-glucosidase. Mahdi et al [ 37 ] revealed that the ethyl acetate fraction of S. officinalis hydro-methanol decoction extract had the best antidiabetic activity tested both by α-amylase and α-glucosidase assays, which corresponded to the highest content of phenolic compounds. In this study, we show that tannins contributed the most to the observed enzyme inhibition activity of Salvia extracts which was indicated by the high correlation coefficient ( r = 0.7934).…”

Section: Resultsmentioning

confidence: 99%

Comparative Antioxidant, Anti-Acetylcholinesterase and Anti-α-Glucosidase Activities of Mediterranean Salvia Species

Mervić

Štefan

Kindl

et al. 2022

Plants

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Salvia species have a cosmopolitan distribution and comprise several well-known plants valuable for pharmaceutical and food industries due to their recognized medicinal, food flavouring, and preservative properties. The present study aimed to evaluate and compare the biological activities of seven wild-growing Salvia species from the Mediterranean area (S. fruticosa, S. glutinosa, S. nemorosa, S. officinalis, S. pratensis, S. sclarea, S. verticillata). All studied ethanolic leaf extracts exhibited significant DPPH and NO radical scavenging ability, lipid peroxidation inhibition, and reducing power, as well as moderate iron-chelating properties. Together with S. officinalis and S. fruticosa, S. verticillata showed anti-acetylcholinesterase activity, while S. glutinosa was also found to possess the ability to inhibit α-glucosidase. Total flavonoid (0.37–0.90%), phenolic acid (3.55–12.44%), tannin (1.22–2.60%), and anthocyanin contents (0.03–0.08%) were determined in Salvia leaves. Rosmarinic acid was the predominant hydroxycinnamic acid in all studied sage plants, ranging from 9400 to 38,800 μg/g. The correlation study showed a strong relationship between biological activities and contents of total phenolic acids, total tannins, and rosmarinic acid, indicating their significant contribution to the efficiency of tested Salvia species. Our results highlighted Mediterranean sage plants as rich sources of potent antioxidant, neuroprotective, and hypoglycemic agents which are worthy of further research.

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“…A recent study showed that the SVO could reduce the aldose reductase activity, which plays a crucial role in the pathogenesis of DM complications (42). Another in vitro investigation also demonstrated that SVO extract has inhibitory effects on αglucosidase and α-amylase activities that may control the postprandial hyperglycemia (43). Furthermore, the clinical evidence was also in favor of administrating the agent for DM cases, as the consumption of SVO reduced insulin resistance in polycystic ovary syndrome patients (44).…”

Section: Figurementioning

confidence: 99%

Salvia Officinalis Protects Pancreatic Beta-cells Against Streptozotocin-Induced Damage; A Stereological Study

Ashkani-Esfahani

Noorafshan

Ebrahimi

et al. 2021

Jundishapur J Nat Pharm Prod

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Background: Diabetes mellitus (DM) is a chronic disease, progressing due to inadequate secretion of insulin by pancreas. Salvia officinalis (SVO) has anti-inflammatory and anti-oxidative potentials, which may be beneficial in regulating underlying causes of DM. Objectives: In this study, we aimed to estimate the protective effects of SVO against Streptozotocin (STZ)-induced pancreatic injury in rat models of DM. Methods: Forty-eight male Sprague-Dawley rats were randomly divided into four groups (n = 12); C1: normal group with no treatment, C2: diabetic group with no treatment, E1: diabetic group treated with 200 mg/kg of the SVO extract, and E2: diabetic group treated with 400 mg/kg of the SVO extract. All groups received a single dose of STZ on day 7 except C1. Pancreas volume, shrinkage, volume densities of the islets, numerical densities, and volume of the beta cells were measured using stereological methods. Results: Blood sugar (BS) levels were significantly lower in SVO-treated groups comparing to C2 group. Also, volume densities and total number of islets and beta cells in E1 and E2 groups were higher than C2 (P < 0.05), but lower than C1 (P < 0.05). Volume densities of the islets and beta cells, and total number of beta cells in E1, and volume densities of the islets and beta cells in E2 groups were considerably higher than C2 group (P < 0.05). Conclusions: Our result showed the beneficial effects of SVO extract regarding pancreatic damage. We concluded that SVO might be prescribed as a therapeutic food supplement for patients with diabetes.

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Evaluation of in vitro α-amylase and α-glucosidase inhibitory potential and hemolytic effect of phenolic enriched fractions of the aerial part of Salvia officinalis L.

Cited by 12 publications

References 25 publications

Chemical Composition, Antioxidant, and α-Glucosidase-Inhibiting Activity of Aqueous and Hydroethanolic Extracts of Traditional Antidiabetics from Croatian Ethnomedicine

Chemical Composition, Antioxidant, and α-Glucosidase-Inhibiting Activity of Aqueous and Hydroethanolic Extracts of Traditional Antidiabetics from Croatian Ethnomedicine

Comparative Antioxidant, Anti-Acetylcholinesterase and Anti-α-Glucosidase Activities of Mediterranean Salvia Species

Salvia Officinalis Protects Pancreatic Beta-cells Against Streptozotocin-Induced Damage; A Stereological Study

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