Evaluation of In Vitro Wettability of Soft Contact Lenses Using Tear Supplements

Iwashita, Hiroko; Itokawa, Takashi; Suzuki, Takashi; Okajima, Yukinobu; Kakisu, Koji; Hori, Yuichi

doi:10.1097/icl.0000000000000698

Cited by 9 publications

(14 citation statements)

References 36 publications

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“…Higher values of this parameter for silicone hydrogel contact lenses may be related to the bulk content of the Si-rich hydrophobic phase reaching over 30% [70]. Similar studies were carried out by Iwashita et al [71], who made the opposite conclusion that CA values associated with the silicone hydrogel contact lenses were significantly lower than those associated with the hydrogel contact lenses. In addition, storing the contact lenses in HA increased CA values.…”

Section: Discussionmentioning

confidence: 78%

Influence of Selected Ophthalmic Fluids on the Wettability and Hydration of Hydrogel and Silicone Hydrogel Contact Lenses—In Vitro Study

Chwalik-Pilszyk

Wiśniewska

2022

Materials

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This study attempts to evaluate the effect of incubation in selected ophthalmic fluids on contact lenses (Etafilcon A, Omafilcon A, Narafilcon A, Senofilcon A). Four research groups differing in the incubation environment were created: (1) initial state, (2) contact lens solution (CLS), (3) contact lens solution and eye drops (ED) and (4) eye drops. Dehydration by gravimetric method and the contact angle (CA) by the sessile drop method were tested. The surface free energy (SFE) was also calculated with the use of several methods: Owens–Wendt, Wu, Neumann, and Neumann–Kwok. The greatest changes in the dehydration profile were observed for contact lenses incubated in ED. The most noticeable changes in CA values were observed for contact lenses incubated in ED, in which it was not possible to settle water drop after incubation. On the basis of SFE analysis, higher values were found for hydrogel contact lenses, e.g., according to the Owens–Wendt method, they ranged from 54.45 ± 6.56 mJ/m2 to 58.09 ± 4.86 mJ/m2, while in the case of silicone-hydrogel contact lenses, they ranged from 32.86 ± 3.47 mJ/m2 to 35.33 ± 6.56 mJ/m2. Incubation in all tested environments decreased the SFE values, but the differences were in most cases statistically insignificant. Calculating the SFE may be a useful method as it can be used to estimate the possibility of bacteria adhering to contact lens surfaces.

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Section: Discussionmentioning

confidence: 78%

Influence of Selected Ophthalmic Fluids on the Wettability and Hydration of Hydrogel and Silicone Hydrogel Contact Lenses—In Vitro Study

Chwalik-Pilszyk

Wiśniewska

2022

Materials

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“… 16 , 29 CA may vary depending upon the SCL material, 16 tear component, 37 and tear supplements. 29 TMH representing the tear volume reduced while wearing the SCL compared to the TMH before wearing the SCL. 38 Chen et al reported that lower the tear volume with SCLs, higher the subjective symptoms.…”

Section: Discussionmentioning

confidence: 99%

“…CA was measured using the sessile drop technique by the CA analyzer (Drop Master DMs-401, Kyowa Interface Science Co., Ltd., Nobitome Niiza, Japan). 29 Five new samples of each type of SCLs were evaluated using saline. After retrieval from the blister pack, the SCLs were carefully grasped at the edge using forceps and were carefully contacted with a cloth (TechniCloth TX604, Texwipe, Kernersville, NC) only at the edge to remove the excess liquid.…”

Section: Methodsmentioning

confidence: 99%

<p>Comparison and Evaluation of Prelens Tear Film Stability by Different Noninvasive in vivo Methods</p>

Itokawa

Suzuki

Iwashita

et al. 2020

OPTH

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Purpose Prelens tear film stability of soft contact lens (SCL) play an important role for contact lens discomfort. In this study, we investigated the association between two types of noninvasive methods and evaluated the tear film stability with SCL using the methods. Patients and Methods In experiment 1, images of ring mire were recorded with a keratograph after focusing the pigment located at the front or back of the SCL. Interferometry and videokeratoscopy were used for the assessment of tear film stability in the right eye of 10 women, with two different cosmetic daily disposable SCLs: polymacon and etafilcon A with polyvinylpyrrolidone. Time to first distortion by noninvasive keratograph break up time (NIKBUT-first) was compared to noninvasive interferometry break up time (NIBUT). In experiment 2, ten normal females wore two different daily disposable SCLs: samfilcon A and narafilcon A. NIKBUT-first and NIBUT were compared between the lenses after 8 hours of SCL wearing. Results In experiment 1, NIBUT-first without SCL was significantly correlated to NIBUT without SCL (r=0.445, P=0.0488, Pearson’s correlation coefficients). However, NIKBUT-first with SCL was not significantly correlated with NIBUT with SCL. In experiment 2, although NIKBUT-first was not significantly different between SCLs, samfilcon A had significantly longer NIBUT than narafilcon A (P=0.0315, paired t -test). Conclusion NIKBUT-first with SCL could be related to tear film stability between the lens and the corneal surface, but not to prelens tear film stability. NIIBUT could be a suitable method to evaluate prelens tear stability.

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“…In addition to having varying physicochemical properties, wetting agents interact differently with different contact lens materials. Using a modified in vitro method, the wettability of hydrogel and SiHy contact lens materials using a sessile drop composed of either saline or three different artificial tear solutions has been measured [224]. The study found that contact angles were generally lower for hydrogels compared to SiHys and for a lubricant solution containing 2-methacryloyloxyethyl phosphorylcholine compared to another lubricant solution containing HA.…”

Section: Rewetting Dropsmentioning

confidence: 99%

BCLA CLEAR - Contact lens wettability, cleaning, disinfection and interactions with tears

Willcox

Keir

Maseedupally

et al. 2021

Contact Lens and Anterior Eye

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Contact lens materials have undergone significant changes over the past 20 years, particularly with respect to the introduction of silicone hydrogel materials. Whilst this development addressed hypoxic issues, other important areas relating to contact lens success, notably comfort, require further research.Contact lens wettability remains a crucially important part of biocompatibility. Contact lenses can be made more wettable by incorporation of surfactants into blister packs, internal wetting agents, surface treatments or care solutions. However, there remains no clear association between contact lens wettability and comfort, making it challenging to determine the potential for these approaches to be of significant clinical benefit. Most contact lenses are used on a daily wear, reusable basis, which requires them to be disinfected when not worn. The ideal disinfecting solution would also improve comfort during wear. However, balancing these requirements with other factors, including biocompatibility, remains a challenge. Soft lens materials invariably take up and subsequently release certain components of disinfecting solutions onto the ocular surface. This may affect tear film stability and the normal ocular microbiome, and further research is needed in this area to determine whether this has any affect on comfort. Finally, contact lens materials sorb components of the tear film, and these interactions are complex and may change the biochemistry of the tear film, which in turn may affect their comfort.In conclusion, the interaction between lens materials, tear film and disinfection solution plays an important role in the biocompatibility of lenses. However, the exact role and whether this can be altered to improve biocompatibility and comfort during wear remains debatable. This report summarises the best available evidence to examine this complex relationship and the opportunities for practitioners to enhance in-eye comfort of contemporary lenses, along with providing suggestions for areas of study that may provide further information on this topic.

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Evaluation of In Vitro Wettability of Soft Contact Lenses Using Tear Supplements

Cited by 9 publications

References 36 publications

Influence of Selected Ophthalmic Fluids on the Wettability and Hydration of Hydrogel and Silicone Hydrogel Contact Lenses—In Vitro Study

Influence of Selected Ophthalmic Fluids on the Wettability and Hydration of Hydrogel and Silicone Hydrogel Contact Lenses—In Vitro Study

<p>Comparison and Evaluation of Prelens Tear Film Stability by Different Noninvasive in vivo Methods</p>

BCLA CLEAR - Contact lens wettability, cleaning, disinfection and interactions with tears

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