Evaluation of in vitro release kinetics of Capsaicin-loaded chitosan nanoparticles using DDSolver

Abstract

The present aim is to evaluate the release profile and its release kinetics of encapsulated capsaicin from chitosan nanoparticles using the software DDSolver. The release study was performed by using a dialysis technique in PBS solutions with different pHs (1.2, 6.8 and 7.4) to mimics the different gastrointestinal tract and circulatory system pH ranges as a releasing medium. The nanoparticles were prepared using o/w emulsification and ionotropic gelation technique under optimal condition obtained from response surface methodology (RSM) design as described in our previous study. These nanoparticles were around 180 nm in average hydrodynamic size and encapsulation efficiency percentage around 70%, respectively. In vitro drug release study suggested that the chitosan nanoparticles can potentially use to controlled and sustained release of capsaicin over at least 96. The kinetic release analysis results by DDSolver software indicated that Weibull model was suggested to be the best dynamic models with highest R2adjusted and model selection criteria (MSC) and lowest Akaike information criterion (AIC), respectively, for capsaicin loaded chitosan nanoparticles. The release mechanism of capsaicin from nanoparticles was found to be Fickian diffusion. The results suggest that the chitosan nanoparticles can be applied for the controlled and sustained release of capsaicin in the gastrointestinal tract and circulatory system.

Formulation, optimization and characterization of allantoin-loaded chitosan nanoparticles to alleviate ethanol-induced gastric ulcer: in-vitro and in-vivo studies

“…7 A). These results resembles an earlier study 62 . Additionally, besides the release characteristics of the formulation, the physicochemical properties of the drug might influence such behaviour.…”

“…Moreover, supplementary analysis by Korsmeyer-Peppas and Weibull mathematical models established a Fickian mechanism, n < 0.5 and β ≤ 0.75, elucidating that the drug release from NPs was substantially governed by diffusion. Similar kinetic behavior of other drugs loaded in CS/STPP NPs was previously reported 62 , 63 .…”

Drug release study of the chitosan-based nanoparticles

“… CSNPs controlled and sustained release of CAP. Release kinetics followed the Weibull model with Fickian diffusion [ 123 ] Ionic crosslinked Freeze-dried CS scaffolds Diclofenac sodium Porous CS scaffolds loaded with model drug diclofenac sodium SF methods A swelling-dependent release is affected by significant changes in pore size and porosity. Crosslinking affects increasing compactness and decreasing overall porosity.…”

“…Furthermore, at an acidic pH, the electrostatic attraction between protonated amine groups and H2O molecules was more significant, dissolves CS polymers, resulting in NPs matrix erosion and rapid drug release [ 123 ]. NPs swelled significantly and even dissociated rapidly, resulting in the quick model drug release [ 132 ].…”

“…The Hixson-Crowell model was used to study dissolution-type release kinetics due to changes in surface area or particle diameter [ 140 ]. As shown in Table 1 , the model release from CSNPs has various models: the zero-order [ 137 ], Hixson-Crowell [ 125 ], Higuchi [ 127 ], Weibull [ 123 ], and the Korsmeyer-Peppas [ 136 ].…”