Evaluation of in vitro neurotoxicity of methyl mercury, PCB153 and PCB126

An in vitro approach to assess the toxicity of certain food contaminants: Methylmercury and polychlorinated biphenyls

“…Cerebellar granule neurons prepared from Gclm (−/−) mice [that lack the modifier subunit of glutamatecysteine ligase (GCLM), the rate limiting step in the synthesis of GSH], and from wild-type mice were used for this purpose . Preliminary results of these studies have been presented (Vitalone et al, 2006.…”