Evaluation of in vitro bioactivity and angiogenesis-promoting effect for mesoporous bioactive glass codoped with copper and silver

Li, Yi-Ju; Wong, Kin Weng; Huang, Ya-Chi; Chien, Chi-Sheng; Shih, Chi‐Jen

doi:10.1016/j.jnoncrysol.2023.122371

Cited by 7 publications

(5 citation statements)

References 25 publications

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“…Moreover, Li and co-workers [77] studied the combination of silver antibacterial capacity and copper angiogenesis-promoting properties. Prepared through a sol-gel method, these MBGNs underwent an in vitro bioactivity assay to assess their capability to form hydroxyapatite in phosphate-buffered saline.…”

Section: Mms Based On Silicon and Titanium Derivates As Antimicrobial...mentioning

confidence: 99%

“…Bone formation [77] MBGNs/copper ions S. aureus Antibacterial [78] Phosphate-based mesoporous glasses/ Cu ions S. aureus, E. coli Bioabsorbable materials [79] Zn-MBG S. aureus, E. coli Implants-associated infections [80] Zn/SBA-1/SBA-15 E. coli, B. subtilis Bone regeneration [81] Tricalcium silicate/MBGNs/Li S. aureus, E. coli Biomedical applications [82] MBGNs/Ce-Co S. aureus Wound healing [83] Na and colleagues presented an approach against antimicrobial infections by combining antibiotics with photothermal therapy using multifunctional nanomaterials [84]. In this study, the inherent photothermal efficiency of two-dimensional rhenium disulfide (ReS 2 ) nanosheets was heightened by coating them on mesoporous silica nanoparticles (MSNs) to create a highly efficient light-responsive nanomaterial with controlled-release drug delivery capabilities, known as MSN-ReS 2 .…”

Section: Aureusmentioning

confidence: 99%

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Advances in Nanomaterials and Composites Based on Mesoporous Materials as Antimicrobial Agents: Relevant Applications in Human Health

Gomez,

Hamer,

Regiart

et al. 2024

Antibiotics

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Nanotechnology has emerged as a cornerstone in contemporary research, marked by the advent of advanced technologies aimed at nanoengineering materials with diverse applications, particularly to address challenges in human health. Among these challenges, antimicrobial resistance (AMR) has risen as a significant and pressing threat to public health, creating obstacles in preventing and treating persistent diseases. Despite efforts in recent decades to combat AMR, global trends indicate an ongoing and concerning increase in AMR. The primary contributors to the escalation of AMR are the misuse and overuse of various antimicrobial agents in healthcare settings. This has led to severe consequences not only in terms of compromised treatment outcomes but also in terms of substantial financial burdens. The economic impact of AMR is reflected in skyrocketing healthcare costs attributed to heightened hospital admissions and increased drug usage. To address this critical issue, it is imperative to implement effective strategies for antimicrobial therapies. This comprehensive review will explore the latest scientific breakthroughs within the metal–organic frameworks and the use of mesoporous metallic oxide derivates as antimicrobial agents. We will explore their biomedical applications in human health, shedding light on promising avenues for combating AMR. Finally, we will conclude the current state of research and offer perspectives on the future development of these nanomaterials in the ongoing battle against AMR.

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Section: Mms Based On Silicon and Titanium Derivates As Antimicrobial...mentioning

confidence: 99%

Section: Aureusmentioning

confidence: 99%

Advances in Nanomaterials and Composites Based on Mesoporous Materials as Antimicrobial Agents: Relevant Applications in Human Health

Gomez,

Hamer,

Regiart

et al. 2024

Antibiotics

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“…Because of the properties previously mentioned, bioactive glasses are increasingly being investigated for their application in soft tissue regeneration. These bioactive glass materials release ions that can stimulate cell functions, induce angiogenesis [28,29], and exhibit antimicrobial properties [30,31], making them suitable for different stages of the wound healing process [13].…”

Section: Introductionmentioning

confidence: 99%

Bioactive-Glass-Based Materials with Possible Application in Diabetic Wound Healing: A Systematic Review

Vargas Guerrero,

Aendekerk,

de Boer

et al. 2024

IJMS

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Diabetes affected 537 million adults in 2021, costing a total of USD 966 billion dollars in healthcare. One of the most common complications associated with diabetes corresponds to the development of diabetic foot ulcers (DFUs). DFUs affect around 15% of diabetic patients; these ulcers have impaired healing due to neuropathy, arterial disease, infection, and aberrant extracellular matrix (ECM) degradation, among other factors. The bioactive-glass-based materials discussed in this systematic review show promising results in accelerating diabetic wound healing. It can be concluded that the addition of BG is extremely valuable with regard to the wound healing rate and wound healing quality, since BG activates fibroblasts, enhances M1-to-M2 phenotype switching, induces angiogenesis, and initiates the formation of granulation tissue and re-epithelization of the wound. In addition, a higher density and deposition and better organization of collagen type III are seen. This systematic review was made using the PRISMA guideline and intends to contribute to the advancement of diabetic wound healing therapeutic strategies development by providing an overview of the materials currently being developed and their effect in diabetic wound healing in vitro and in vivo.

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“…Bone defects caused by congenital diseases, bone tumors, trauma, and other reasons are common clinical diseases, and different repair materials are needed to promote the new bone formation in their treatment. , However, most of the clinically used bone repair materials usually show insufficient osteoconductive and osteoinductive ability. , Bioactive glass, a kind of silicate glass composed of basic components such as SiO 2 , Na 2 O, CaO, and P 2 O 5 , can quickly form the hydroxyapatite layer on its surface in the physiological environment, showing excellent osteoconductivity and biocompatibility. , Mesoporous bioactive glass (MBG) with abundant mesoporous pore and a large specific surface area has the capacity to degrade over time and release ions, providing abundant calcium and phosphorus for new bone formation. , Studies have tried to load growth factors to the mesoporous structure of MBG to enhance the osteoinductive ability; however, exogenous growth factors still have limitations in clinical applications due to their short half-life, inflammation, ectopic osteogenesis, and so on. − Based on the specific biological functions of some trace elements as well as the degradability and ion release ability of MBG, ion-doped MBG has attracted extensive attention in the field of bone defect repair. − …”

Section: Introductionmentioning

confidence: 99%

Vanadium-Doped Mesoporous Bioactive Glass Promotes Osteogenic Differentiation of rBMSCs via the WNT/β-Catenin Signaling Pathway

Cong,

Zhang,

et al. 2023

ACS Appl. Bio Mater.

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Pentavalent vanadium [V(V)] has been studied as bioactive ions to improve the bone defect repair; however, its osteogenic promotion mechanism is still not fully understood so far. In this study, a V-doped mesoporous bioactive glass (V-MBG) was prepared, and its effects on osteogenic differentiation of rat bone marrow mesenchymal stem cells (rBMSCs) and potential signaling pathways were investigated. The physicochemical characterization revealed that the incorporation of V slightly reduced the specific surface area and increased the mesoporous pore size, and the abundant mesopores of V-MBG were beneficial to the sustained dissolution of V(V) ions as well as calcium, silicon, and phosphorus ions. Cell proliferation results indicated that the high dilution ratio (>16) V-MBG extract markedly promoted the proliferation of rBMSCs compared with the control group and the same dilution ratio MBG extract. Compared with the same dilution ratio MBG extract, diluted V-MBG extracts markedly promoted the secretion of alkaline phosphatase (ALP) and osteocalcin (OCN) protein at day 7 but insignificantly stimulated the runt-related transcription factor 2 (RUNX2) and vascular endothelial growth factor (VEGF) protein synthesis. In depth, the diluted V-MBG extracts remarkably up-regulated the expression of WNT/β-catenin pathway direct target genes, including WNT3a, β-catenin, and AXIN2 genes in contrast to the same dilution ratio MBG extracts, suggesting that the released V(V) ions might promote osteogenic differentiation of rBMSCs via the WNT/β-catenin signaling pathway.

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Evaluation of in vitro bioactivity and angiogenesis-promoting effect for mesoporous bioactive glass codoped with copper and silver

Cited by 7 publications

References 25 publications

Advances in Nanomaterials and Composites Based on Mesoporous Materials as Antimicrobial Agents: Relevant Applications in Human Health

Advances in Nanomaterials and Composites Based on Mesoporous Materials as Antimicrobial Agents: Relevant Applications in Human Health

Bioactive-Glass-Based Materials with Possible Application in Diabetic Wound Healing: A Systematic Review

Vanadium-Doped Mesoporous Bioactive Glass Promotes Osteogenic Differentiation of rBMSCs via the WNT/β-Catenin Signaling Pathway

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