Evaluation of in vitro anticancer activity of 1,8-Cineole–containing n-hexane extract of Callistemon citrinus (Curtis) Skeels plant and its apoptotic potential

Pharmacological properties and therapeutic potential of saffron (Crocus sativus L.) in osteosarcoma

“…Levels of IL‐6 and 8 were analysed in osteosarcoma cells incubated with the saffron extracts. IL‐6 and IL‐8 are inflammatory mediators released as a result of oxidative stress . Oxidative stress is one of the important enhancers of carcinogenesis as it generates mutations and chromosomal defects in cells .…”

“…In contrast to our observations, saffron from other parts of world was shown to increase levels of some inflammatory mediators including IL-6 in patients with metabolic syndrome. [7] Similarly, acetone extract of saffron flower was also reported to enhance levels of IL-6 and IL-8. Some other studies also reported anti-inflammatory activity of saffron, suggesting that the anti-inflammatory functions of saffron vary depending on the plant material and extracts with different chemical nature.…”

“…Thus, Safranbolu saffron can be considered as a safe chemotherapeutic agent for osteosarcoma treatments. In contrast to our observations, saffron from other parts of world was shown to increase levels of some inflammatory mediators including IL‐6 in patients with metabolic syndrome . Similarly, acetone extract of saffron flower was also reported to enhance levels of IL‐6 and IL‐8.…”

“…IL-6 and IL-8 are inflammatory mediators released as a result of oxidative stress. [7] Oxidative stress is one of the important enhancers of carcinogenesis as it generates mutations and chromosomal defects in cells. [17] Therefore, identifying or developing novel chemotherapeutic agents that do not cause inflammation is very important.…”

“…Therefore, compounds isolated from several plant species have identified to have strong anticancer activity on cancer cells . In particular, several plant‐based chemotherapeutic drugs such as vinblastine, vinorelbine, vincristine, vindesine, taxol and camptothecin are currently on the market with different brand names . For instance, vinblastine, vinorelbine, vincristine, vindesine and vinflunine are five major vinca alkaloids derived from the Madagascar periwinkle plant (Catharanthus roseus G. Don, also called Vinca rosea) .…”