Evaluation of in vitro and in vivo biocompatibility of iron produced by powder metallurgy

Biodegradable Iron-Based Materials—What Was Done and What More Can Be Done?

“…In an analogical test, Liu et al used human umbilical vein endothelial cells (ECV304) and rodent vascular smooth muscle cells [ 54 ]. Another method was chosen by Paim et al using extracted adipose-derived stem cells from the abdominal adipose tissue of a healthy adult donor undergoing tumescent liposuction [ 55 ]. The cells were next subjected to washing and centrifuge procedures.…”

“…If the cell viability is reduced by more than 30%, the material is considered cytotoxic. Based on this recommendation, Paim et al proved that iron is not cytotoxic and can be used as a material in biodegradable stents [ 55 ].…”

“…It is essential to know these basics when performing in vivo testing to see when the body’s response is unnatural and needs to be recorded. At this point, nobody reported problems with infections or rejection of the implant due to the presence of iron [ 55 ]. There is no indication of problems with the compatibility of tissues with iron.…”

“…Iron is hemocompatible since few platelets adhere to it, and the hemolysis rate is well below 5% [ 55 ]. The problem with increased platelet adhesion may arise if Zn or Ag are added to the alloy [ 51 , 67 ].…”

Biyoçözünür İmplant Uygulamaları İçin Saf Çinko Tozlarından İnce Taneli Yapıların İmalatı ve Çözünme Davranışının Karakterizasyonu

“…Aynı zamanda implantın gereğinden uzun bir süre vücut içerisinde kalması farklı problemlere yol açmaktadır. Örneğin stent uygulamaları için, malzeme damar içerisine yerleştirildikten ortalama 6-12 ay sonra işlevini tamamlamalı ve çözünmelidir [7]. Zn çözünme hızı sebebi ile bu yönden avantajlı bir malzemedir.…”