Evaluation of in vitro aldose reductase inhibitory potential of alkaloidal fractions of <i>Piper nigrum, Murraya koenigii, Argemone mexicana</i>, and <i>Nelumbo nucifera</i>

Gupta, Sunil; Singh, Nirmal; Jaggi, Amteshwar Singh

doi:10.1515/jbcpp-2013-0071

Cited by 15 publications

(6 citation statements)

References 62 publications

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“…Aldose reductase has an important role in the development of long-term diabetic complications because of increased polyol pathway activity. Gupta et al revealed potent aldose reductase inhibitory activity of hydroalcoholic and alkaloidal extracts of N. nucifera (Gupta et al, 2014). The stamens of N. nucifera were examined for their possible inhibitory activity on aldose reductase and isolated alkaloids from the ethylacetate soluble fraction of the methanolic extract demonstrate potent aldose reductase inhibitory activity (Lim et al, 2006;Veeresham et al, 2014).…”

Section: Pharmacological Reportsmentioning

confidence: 99%

A Comprehensive Review on Chemical Profiling of Nelumbo Nucifera: Potential for Drug Development

Sharma

Gautam

Adhikari³

et al. 2016

Phytotherapy Research

136

107

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Nelumbo nucifera, also known as sacred lotus, has primarily been used as food throughout the Asian continent, and its medicinal values have been described in Ayurvedic and Traditional Chinese Medicine. The purpose of this study is to systematically characterize the chemical profiling and pharmacological activities of N. nucifera. Herein, we critically reviewed and analysed the phytochemical and pharmacological reports of N. nucifera. Our search for the keyword 'Nelumbo nucifera pharmacology' in all databases reported in Web of Science yielded 373 results excluding reviews and abstracts in document types. Two hundred and forty-three spectrum natural compounds from different parts of N. nucifera belonging to diverse chemical groups, including alkaloids, flavonoids, glycosides, terpenoids, steroids, fatty acids, proteins, minerals, and vitamins have been reported. In addition, distinct pharmacological activities, mainly against cancer, microbial infection, diabetes, inflammation, atherosclerosis, and obesity, have been associated with crude extracts, fractions, and isolated compounds. This review highlights potential use of neferine, liensinine, isoliensinine, and nuciferine in clinical trials. In depth, mechanism of the potential chemical entities from N. nucifera via structure activity relationship needs to be explored to guarantee the stability and safety for the clinical use. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Pharmacological Reportsmentioning

confidence: 99%

A Comprehensive Review on Chemical Profiling of Nelumbo Nucifera: Potential for Drug Development

Sharma

Gautam

Adhikari³

et al. 2016

Phytotherapy Research

136

107

View full text Add to dashboard Cite

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“…The highest hit with Nelumbo nucifera indicates the commonality between these two crops. Both black pepper and Nelumbo nucifera are dicot and have common polyol‐alkaloid pathways, potent aldose reductase inhibitory activity is found in their alkaloidal extracts (Gupta et al, 2014). Both are medicinal plants and have larvicidal and repellent activity in the methanol and ethyl acetate extracts (Kamaraj et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Drought responsiveness in black pepper (Piper nigrum L.): Genes associated and development of a web‐genomic resource

Negi

Kokkat

Jasrotia

et al. 2020

Physiologia Plantarum

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Black pepper (Piper nigrum L.; 2n = 52; Piperaceae), the king of spices, is a perennial, trailing woody flowering vine and has global importance with widespread dietary, medicinal, and preservative uses. It is an economically important germplasm cultivated for its fruit and the major cash crop in >30 tropical countries. Crop production is mainly affected by drought stress. The present study deals with the candidate gene identification from drought-affected black pepper leaf transcriptome generated by Illumina Hiseq2000. It also aims to mine putative molecular markers (namely SSRs, SNPs, and InDels) and generate primers for them. The identification of transcription factors and pathways involved in drought tolerance is also reported here. De novo transcriptome assembly was performed with trinity assembler. In total, 4914 differential expressed genes, 2110 transcriptional factors, 786 domains and 1137 families, 20,124 putative SSR markers, and 259,236 variants were identified. At2g30105 (unidentified gene containing leucine-rich repeats and ubiquitin-like domain), serine threonine protein kinase, Mitogen-activated protein kinase, Nucleotide Binding Site-Leucine Rich Repeat, Myeloblastosis-related proteins, basic helix-loop-helix are all found upregulated and are reported to be associated with plant tolerance against drought condition. All these information are catalogued in the Black Pepper Drought Transcriptome Database (BPDRTDb), freely accessible for academic use at http:// webtom.cabgrid.res.in/bpdrtdb/. This database is a good foundation for the genetic improvement of pepper plants, breeding programmes, and mapping population of this crop. Putative markers can also be a reliable genomic resource to develop droughttolerant variety for better black pepper productivity.

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“…The same study also showed that the flavanoid of M. paniculata significantly blocked the decrease of superoxide dismutase and glutathione peroxidase and the increase of malondialdehyde levels in diabetic rats. On the other hand, studies with isolated coumarin of Murraya genus, respectively, showed hypoglycemic activity and inhibitory effect on the activity of the enzyme aldose reductase (Gacche and Dhole, ; Gupta et al, ) and on platelet aggregation (Chia et al, ), which are considered to be important causes of diabetic complications.…”

Section: Discussionmentioning

confidence: 99%

Murraya paniculata(L.) (Orange Jasmine): Potential Nutraceuticals with Ameliorative Effect in Alloxan‐Induced Diabetic Rats

Menezes

Garcia

Viana

et al. 2017

Phytotherapy Research

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Orange jasmine, Murraya paniculata (Rutaceae), is a plant from India widely used in folk medicine as antinociceptive, antiinflammatory, and antioxidant. Although oral hypoglycemic agents and insulin are the mainstays of treatment of diabetes mellitus (DM), there is a significant demand for new natural products to reduce the development of diabetic complications. Alloxan-induced diabetic rats were treated for 60 days with a hydroalcoholic extract of M. paniculata (MPE), at doses of 100, 200, and 400 mg/kg. MPE decreased glycemia and also cholesterol and triglyceride levels, starting 1 week after treatments, as compared with the same group before treatments. Glucose values were reduced toward normality after 1 week of treatment. MPE hypoglycemic effects were potentiated by glibenclamide and metformin. MPE also decreased fructosamine and glycated hemoglobin values. MPE reduced diabetes-induced morphological alterations of the kidney, pancreas, and liver. MPE acts similarly to glibenclamide and metformin, and its glucose-lowering action is partly a consequence of ATP-sensitive K channel inhibition. MPE may be a potential therapeutic alternative for the treatment of diabetes and its complications. Copyright © 2017 John Wiley & Sons, Ltd.

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Evaluation of in vitro aldose reductase inhibitory potential of alkaloidal fractions of Piper nigrum, Murraya koenigii, Argemone mexicana, and Nelumbo nucifera

Abstract: It may be concluded that the alkaloidal extracts of these plants possess potent aldose reductase inhibitory activity and may be therapeutically exploited in diabetes-related complications associated with increased activity of aldose reductase.

Cited by 15 publications

References 62 publications

A Comprehensive Review on Chemical Profiling of Nelumbo Nucifera: Potential for Drug Development

A Comprehensive Review on Chemical Profiling of Nelumbo Nucifera: Potential for Drug Development

Drought responsiveness in black pepper (Piper nigrum L.): Genes associated and development of a web‐genomic resource

Murraya paniculata(L.) (Orange Jasmine): Potential Nutraceuticals with Ameliorative Effect in Alloxan‐Induced Diabetic Rats

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