Evaluation of In-office Vital Tooth Whitening Combined with Different Concentrations of At-home Peroxides: A Randomized Double-blind Clinical Trial

Abstract

Background: The clinical evidence relate the effect of associating the in-office and at home vital tooth whitening, describing positive effects on tooth color change and reduction of dental sensitivity. Objective: The purpose of this randomized double-blind clinical trial was to evaluate the effect on the shortened application of in-office vital tooth whitening combined with different concentrations of at-home peroxides in the final tooth color change and dental sensitivity. Methods: Randomized double-blind clinical trial with 120 participants between 18-65 years, allocated in four tooth whitening treatment groups: G1= Carbamide Peroxide 10% + Hydrogen Peroxide 40%, G2= Carbamide Peroxide 15% + Hydrogen Peroxide 40%, G3= Carbamide Peroxide 20% + Hydrogen Peroxide 40%, G4= Hydrogen Peroxide 10% + Hydrogen Peroxide 40% was conducted. Tooth color was measured at baseline and dental sensitivity and tooth color change during and after treatment. Results: No statistical significant differences were found in tooth color change (superior arch p= 0.183 / inferior arch p= 0.374), and in dental sensitivity (p=0.268). Conclusion: Reducing the application time of in-office whitening, combined with in-home products was effective in improving the color. All groups resulted in identical final color change and dental sensitivity. Clinicaltrials.gov: NCT02682329 Available from: https://clinicaltrials.gov/ct2/show/NCT02682329?term=hydrogen+peroxide.

Dental sensitivity in tooth whitening and its relationship to peroxides concentrations: a cross-sectional retrospective study

“…Detailed information regarding tooth whitening effectiveness in terms of color change could be found on the original RCT (17). Remove the tray and align it correctly over your teeth.…”

“…In this framework, Feliz-Matos et al reported the results of a randomized clinical trial (RCT), in 2018, where it was combined different concentrations of peroxides with the ambulatory and in-office VTW techniques. The research showed favourable outcomes in terms of tooth color change, dental sensitivity and length of the treatment (16,17). This has been one of the few recent studies that have evaluated the association of dental sensitivity with distinct percentages of the whitening agents employing the combined technique, because most of the authors have focused their investigations on the at-home or in-office techniques applied individually (18)(19)(20).…”

“…The dataset was selected from one of the four groups (group #4) studied in the RCT, composed of 27 de-identified subjects who attended the dental clinic of Universidad Iberoamericana (UNIBE), Santo Domingo, Dominican Republic, from September 2013-February 2014 (17). The time span was determined by the sample behaviour, taking into account that a non-probabilistic sample was chosen.…”

“…Details of the composition and mode of applications recommended by the manufacturer of the whitening products are described in Table 1 (17).…”

Estratégias Contra O Uso Abusivo De Drogras: Uma Revisão Sobre Vacinas Imunofarmacoterapicas

“…Ademais, o uso desse gel em baixas concentrações tem a vantagem de promover uma agressão reduzida a polpa, assim minimiza o risco e a intensidade de indução da sensibilidade dentinária(REZENDE et al, 2016). Já uma concentração maior do produto fornece resultados mais rápidos, porém promove sensibilidade dentinária numa intensidade de média a severa(FÉLIZ- MATOS et al, 2019).Além disso, Féliz-Matos et al (2019) mostraram que no clareamento caseiro há uma mudança de cor significativa independentemente da concentração utilizada, entre 10 a 20%. Outro importante ponto a ser analisado é a utilização do peróxido de hidrogênio em baixas concentrações em comparação ao uso de peróxido de carbamida no tratamento caseiro,Cardenas et al (2019) afirmaram que o branqueamento com peróxido de carbamida produz maior eficácia em termos de mudança de cor.…”