Evaluation of immunohistochemical expression of E-cadherin in pleomorphic adenoma and adenoid cystic carcinoma

Sangala, BhavaniNagendra; Raghunath, Vandana; Kavle, Pratibha; Gupta, Anish; Gotmare, SwatiShrikant; Andey, VenkataSubhash

doi:10.4103/jomfp.jomfp_337_21

Cited by 1 publication

(4 citation statements)

References 31 publications

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“…Although not significant, we observed low E‐cadherin immunostaining in the membrane and cytoplasm in 65% of PA cases, 78% of ACC cases, and 65% of MEC cases. Previous studies investigating the same salivary gland tumors found different E‐cadherin immunostaining, 8–11,13–15 although other authors did not observe any significant difference when PA and ACC were compared as a whole 12 . These findings could be attributable to tumor heterogeneity and loss of cellular cohesion due to extracellular matrix.…”

Section: Discussionmentioning

confidence: 84%

“…The EMT is a biological event that occurs in many cancers, including those originating in salivary glands. [10][11][12] It involves a polarized epithelial cell that is altered to a mesenchymal phenotype with increased migratory and invasive capacities. 5 The present results demonstrated a significantly higher expression of the transcription factors SNAIL, SLUG, and TWIST in the malignant neoplasms studied than PA.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies investigating the same salivary gland tumors found different E-cadherin immunostaining, [8][9][10][11][13][14][15] although other authors did not observe any significant difference when PA and ACC were compared as a whole. 12 These findings could be attributable to tumor heterogeneity and loss of cellular cohesion due to extracellular matrix.…”

Section: Discussionmentioning

confidence: 99%

“…The EMT is a biological event that occurs in many cancers, including those originating in salivary glands 10–12 . It involves a polarized epithelial cell that is altered to a mesenchymal phenotype with increased migratory and invasive capacities 5 .…”

Section: Discussionmentioning

confidence: 99%

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E‐CADERIN, N‐CADERIN, SLUG, SNAIL, and TWIST contribute to epithelial‐mesenchymal transition in salivary gland tumors

de Santana,

Braga,

Camillo‐Coutinho

et al. 2024

J Oral Pathology Medicine

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BackgroundTranscription factors are important in the epithelial‐mesenchymal transition process and are possibly related to the development of a more invasive tumor phenotype. Thus, the objective of this study was to analyze the expression and identify the localization of cellular markers related to the epithelial‐mesenchymal transition process in salivary gland tumors.Study DesignThe expression and localization of E‐CADERIN, N‐CADERIN, SLUG, SNAIL, and TWIST were evaluated, using immunohistochemistry, in 48 salivary gland tumors, being 17 pleomorphic adenomas (PA), 14 adenoid cystic carcinomas (ACC), and 17 mucoepidermoid carcinomas (MEC). these proteins were compared to clinical and histopathologic parameters. normal gland tissues were included for immunohistochemical comparisons.ResultsACC and MEC cases showed higher expression of SNAIL compared to PA. MEC showed high expression of SLUG and TWIST. Low expression of N‐CADHERIN, SNAIL, and TWIST in ACC was frequent in T3 and T4. High expression of TWIST in MEC was more frequent at age ≥ 40 years A positive correlation was only observed between N‐cadherin/SNAIL in ACC, between SNAIL/TWIST in MEC, and between SLUG/TWIST in PA.ConclusionThis study provided insight into EMT‐related proteins (E‐cadherin, N‐cadherin, SNAIL, SLUG, and TWIST) and their contribution to the maintenance of morphogenesis and the development of the salivary gland tumors and showed a positive correlation among N‐CADHERIN/SNAIL in ACC and SNAIL/TWIST in MEC.

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Section: Discussionmentioning

confidence: 84%