Evaluation of immune protection induced by DNA vaccines from Haemaphysalis longicornis paramyosin in rabbits

Zhang, Tiantian; Zhang, Jincheng; Cui, Xuejiao; Zheng, Jingjing; Ru, Li; Wang, Fang; Liu, Jingze; Hu, Yonghong

doi:10.1186/s13071-017-2262-x

Cited by 15 publications

(12 citation statements)

References 24 publications

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“…Indeed, the merits and demerits of DNA vaccines have been discussed extensively [ 151 ]. The concept of DNA tick-vaccines has been demonstrated [ 152 , 153 ]. Similarly, chimeric DNA constructs could be combined to formulate cocktail vaccines, however, this could also trigger undesired immunological reactions such as antigenic competition [ 154 ].…”

Section: Can We Enhance the Efficacy Of Cocktail Vaccines?mentioning

confidence: 99%

Cocktail Anti-Tick Vaccines: The Unforeseen Constraints and Approaches toward Enhanced Efficacies

Ndawula

Lew-Tabor

2020

Vaccines

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Ticks are second to mosquitoes as vectors of disease. Ticks affect livestock industries in Asia, Africa and Australia at ~$1.13 billion USD per annum. For instance, 80% of the global cattle population is at risk of infestation by the Rhipicephalus microplus species-complex, which in 2016 was estimated to cause $22–30 billion USD annual losses. Although the management of tick populations mainly relies on the application of acaricides, this raises concerns due to tick resistance and accumulation of chemical residues in milk, meat, and the environment. To counteract acaricide-resistant tick populations, immunological tick control is regarded among the most promising sustainable strategies. Indeed, immense efforts have been devoted toward identifying tick vaccine antigens. Until now, Bm86-based vaccines have been the most effective under field conditions, but they have shown mixed success worldwide. Currently, of the two Bm86 vaccines commercialized in the 1990s (GavacTM in Cuba and TickGARDPLUSTM in Australia), only GavacTM is available. There is thus growing consensus that combining antigens could broaden the protection range and enhance the efficacies of tick vaccines. Yet, the anticipated outcomes have not been achieved under field conditions. Therefore, this review demystifies the potential limitations and proposes ways of sustaining enhanced cocktail tick vaccine efficacy.

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Section: Can We Enhance the Efficacy Of Cocktail Vaccines?mentioning

confidence: 99%

Cocktail Anti-Tick Vaccines: The Unforeseen Constraints and Approaches toward Enhanced Efficacies

Ndawula

Lew-Tabor

2020

Vaccines

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“…In contrast, many ticks are of medical and economic importance, and the prevention and control of ticks has always been received attention. In China, there are many effective control strategies for ticks, including rotational grazing (Dong et al, ), chemical control (Nong et al, ; Rajput, Hu, Chen, Arijo, & Xiao, ), biological control (Ren et al, ; Sun et al, ), and vaccine development (T. T. Zhang et al, ). In such cases, the dynamic changes in ticks also deserve further study.…”

Section: Tick Dynamics Under Environmental Changes and Controlmentioning

confidence: 99%

Ticks (Acari: Ixodoidea) in China: Geographical distribution, host diversity, and specificity

Zhang

Liu

2019

Arch Insect Biochem Physiol

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Ticks are obligate blood‐sucking ectoparasites, which not only directly damage through bites but also transmit many pathogens. China has a high diversity of tick species, 125 species have been reported, including 111 hard tick and 14 soft tick species. Many of the ticks are important vectors of pathogens, resulting in zoonoses. The dynamics of ticks are affected by both the host and habitat environment. However, systematic studies on the geographical distribution, host diversity, and specificity of ticks are limited in China. To achieve this goal, the relevant available data were summarized and analyzed in this study. Ticks are distributed in all parts of China and Xinjiang has the most records of ticks. The distribution of ticks in adjacent areas is similar, indicating that the habitat environment affects their distribution. Most ticks are widely distributed, whereas some species are endemic to their distributed regions. Ticks are parasitic on mammals, birds, and reptiles, of which mammals are the main host species. Overall, most ticks parasitize different hosts, only a few ticks have strict host specificity, such as ticks that are specifically parasitic on reptiles and bats. In addition, environmental changes and control efforts also influence the dynamics of ticks. These results can better reveal tick biological traits and are valuable for tick control.

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“…The abundance of band #1, containing an unknown tick host protein, increased gradually due to the presence of R. slovaca . The main protein in band #3 was identified as paramyosin, an immunomodulatory protein playing an important role in immune reactions against parasites in vertebrate hosts [38]. Finally, the major protein in band #2 was recognised as putative defensin.…”

Section: Resultsmentioning

confidence: 99%

Comparative proteomics of the vector Dermacentor reticulatus revealed differentially regulated proteins associated with pathogen transmission in response to laboratory infection with Rickettsia slovaca

et al. 2019

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Background Tick-borne rickettsial diseases are caused by pathogens acquired from hard ticks. In particular, Rickettsia slovaca , a zoonotic infectious bacterium causing tick-borne lymphadenopathy (TIBOLA), is transmitted by the vectors Dermacentor spp. that can be found all over Europe. Although recent studies point out the extreme complexity of bacteria-induced effects in these blood-feeding vectors, the knowledge of individual molecules involved in the preservation and transmission of the pathogen is still limited. System biology tools, including proteomics, may contribute greatly to the understanding of pathogen-tick-host interactions. Methods Herein, we performed a comparative proteomics study of the tick vector Dermacentor reticulatus that was experimentally infected with the endosymbiotic bacterium R. slovaca . Rickettsia -free ticks, collected in the southern region of Slovakia, were infected with the bacterium by a capillary tube-feeding system, and the dynamics of infection was assessed by quantitative PCR method after 5, 10, 15 and 27 days. Results At the stage of controlled proliferation (at 27 dpi), 33 (from 481 profiled) differentially abundant protein spots were detected on a two-dimensional gel. From the aforementioned protein spots, 21 were successfully identified by tandem mass spectrometry. Conclusions Although a few discovered proteins were described as having structural or housekeeping functions, the vast majority of the affected proteins were suggested to be essential for tick attachment and feeding on the host, host immune system evasion and defensive response modulation to ensure successful pathogen transmission. Electronic supplementary material The online version of this article (10.1186/s13071-019-3564-y) contains supplementary material, which is available to authorized users.

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Evaluation of immune protection induced by DNA vaccines from Haemaphysalis longicornis paramyosin in rabbits

Cited by 15 publications

References 24 publications

Cocktail Anti-Tick Vaccines: The Unforeseen Constraints and Approaches toward Enhanced Efficacies

Cocktail Anti-Tick Vaccines: The Unforeseen Constraints and Approaches toward Enhanced Efficacies

Ticks (Acari: Ixodoidea) in China: Geographical distribution, host diversity, and specificity

Comparative proteomics of the vector Dermacentor reticulatus revealed differentially regulated proteins associated with pathogen transmission in response to laboratory infection with Rickettsia slovaca

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