Evaluation of imidazo[2,1–b]thiazole-based anticancer agents in one decade (2011–2020): Current status and future prospects

Synthesis of Benzo[4,5]thiazolo[2,3-c][1,2,4]triazole Derivatives via C-H Bond Functionalization of Disulfide Intermediates

“…Sulfur- and nitrogen-containing heterocycles are present in many natural products [ 1 , 2 ], agrochemicals [ 3 , 4 , 5 ], commercially available drugs [ 6 , 7 ], and compounds with the potential to become active pharmaceutical ingredients [ 8 , 9 , 10 , 11 , 12 , 13 , 14 ]. As a result, there is continued interest in developing new methods for the synthesis of biologically active fused heterocycles incorporating the benzothiazole fragment [ 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ].…”

Oxidative Cyclization of 4‐(2‐Mercaptophenyl)‐Substituted 4H‐1,2,4‐Triazolium Species to Tricyclic Benzothiazolium Salts

“…The vast majority of biologically active molecules found in pharmaceuticals and agrochemicals bear at least one heterocyclic ring [1–6] . Of particular interest are compounds based on fused heterocyclic scaffolds which exhibit a wide range of biological activity [7–10] . Among these molecules are several fused nitrogen‐ and sulfur‐containing heterocyclic anti‐cancer agents incorporating a (benzo)thiazole fragment, [10–22] a thiadiazole ring, [23–28] or a thiadiazine unit [27–29] .…”

“…[1][2][3][4][5][6] Of particular interest are compounds based on fused heterocyclic scaffolds which exhibit a wide range of biological activity. [7][8][9][10] Among these molecules are several fused nitrogen-and sulfur-containing heterocyclic anti-cancer agents incorporating a (benzo)thiazole fragment, [10][11][12][13][14][15][16][17][18][19][20][21][22] a thiadiazole ring, [23][24][25][26][27][28] or a thiadiazine unit. [27][28][29] The same scaffolds can be found in molecules with antibacterial, antimicrobial and antifungal properties, [22,[30][31][32][33][34][35] prospective therapeutic agents used to treat asthma or chronic obstructive pulmonary disease, [36][37][38] molecules with anti-inflammatory activity, [39] compounds with antidiabetic activity, [40,41] and promising therapeutics to treat Alzheimer's disease…”

[3+2] Cycloaddition Reaction for the Stereoselective Synthesis of a New Spirooxindole Compound Grafted Imidazo[2,1-b]thiazole Scaffold: Crystal Structure and Computational Study

“…Imidazo [2,1-b]thiazole is an important bicyclic nitrogen and sulfur containing compound in some natural as well as synthetic pharmacologically active compounds and agrochemicals [1,2]. Many compounds reported in the literature incorporating imidazothiazole exhibited pharmaceutical targets such as antihelminthic [3], antifungal [4] and antibacterial [5], and also in cancer research development as anti-tumor agents [6][7][8]. Levamisolum is one of the representative pharmaceutically relevant molecules for immunomodulatory and antihelminthic agents which have partially hydrogenated imidazo[2,1-b]thiazole as a core constituent (Figure 1).…”