Evaluation of in vitro antiviral activity in methanol extracts against influenza virus type A from Korean medicinal plants

Abstract

Methanol extracts from 101 Korean medicinal plants were tested for inhibitory activity against influenza virus type A by means of a modified haemagglutination inhibition (HI) test. MM-57, MM-72, MM-104 and MM-110, four of 101 extracts tested exhibited strong anti-influenza virus type A activity at concentration ranges of 0.78-6.25 mg/mL, 0.78-3.13 mg/mL, 0.78-1.56 mg/mL and 0.0975-0.39 mg/mL, respectively. The extracts MM-57, MM-72 and MM-110 showed very strong anti-influenza virus type A activity in the range 1.56-6.25 mg/mL, 1.56-3.13 mg/mL and 195-390 micro g/mL, respectively. The four methanol extracts were weakly cytotoxic to red blood cells. These results demonstrated that four methanol extracts of Korean medicinal plants exhibit strong anti-influenza virus type A activity, and weak cytotoxic effects. They may inhibit attachment of the virus to the cell and may therefore be used for prophylaxis.

Antiviral activities of Cholistani plants against common poultry viruses

“…Similarly, the low IC 50 value of these plants confirms the potential of Cholistani plants against AIV. The similar results are reported by other researchers like (Park, 2003) have reported anti AIV activity from methanol extracts of four Korean medicinal plants. (Lee et al, 2016; et al, 2019) have reported anti AIV activity from n-hexane and ethyl acetate extracts of green tea.…”

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