Evaluation ofin silico, in vitroα-amylase inhibition potential and antidiabetic activity ofPterospermum acerifoliumbark

Rathinavelusamy, Paramaguru; Mazumder, Papiya Mitra; Sasmal, D.; Jayaprakash, Venkatesan

doi:10.3109/13880209.2013.823551

Cited by 6 publications

(6 citation statements)

References 20 publications

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“…The inhibition constant (Ki) for this compound was estimated as 269.35 nmol with two hydrogen bond interactions, although there is no report on the evaluation of fucosterol and β-sitosterol against pancreatic α-amylase activity so far. [ 77 ] Taking together, anti-diabetic sterols of this algae may be responsible at least in part for anti-diabetic activity of Sargassum species. [ 46 ] However, this activity is supposed to be performed via different mechanisms, of which α-amylase inhibitory activity is one of the most critical ones.…”

Section: Resultsmentioning

confidence: 99%

Alpha-amylase inhibitory activity and sterol composition of the marine algae, Sargassum glaucescens

Payghami¹,

Jamili

Rustaiyan³

et al. 2015

Phcog Res

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Background:Sargassum species (phaeophyceae) are economically important brown algae in southern parts of Iran. Sargassum is mainly harvested as a row material in alginate production industries and is a source of plant foods or plant bio-stimulants even a component of animal foods.Objective:In this study, Sargassum glaucescens, collected from the seashore of Chabahar, was employed for phytochemical and biological evaluations.Materials and Methods:For that purpose, the dried algae was extracted by methanol and subjected to different chromatographic separation methods.Results:Six sterols, fucosterol (1), 24(S)-hydroxy-24-vinylcholesterol (2), 24(R)-hydroxy-24-vinylcholesterol (3), stigmasterol (4), β-sitosterol (5) and cholesterol (6) were identified by spectroscopic methods including 1H-NMR, 13C-NMR and mass spectroscopy. In vitro alpha-amylase inhibitory test was performed on the methanolic extract and the results revealed a potent inhibition (IC50 = 8.9 ± 2.4 mg/mL) of the enzyme compared to acarbose as a positive control.Conclusion:Various biological activities and distribution of sterols in Sargassum genus have been critically reviewed here. The results concluded that these algae are a good candidate for further anti-diabetic investigations in animals and human.

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Section: Resultsmentioning

confidence: 99%

Alpha-amylase inhibitory activity and sterol composition of the marine algae, Sargassum glaucescens

Payghami¹,

Jamili

Rustaiyan³

et al. 2015

Phcog Res

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Section: Discussionmentioning

confidence: 99%

“…Trypsin inhibitor was previously isolated by Shee and Sharma (2007) from the seeds of Murraya koenigii which belongs to rutaceae family. Rathinavelusamy et al (2014) previously reported a protein with α-amylase inhibition potential and antidiabetic activity from the bark of Pterospermum acerifolium belonging to malvaceae family. Bijina et al (2011) observed that the crude extract of leaves of Moringa oleifera showed maximum percent of inhibition (77%) followed by the seed extract (63%).…”

Section: Discussionmentioning

confidence: 99%

In vitro screening of peptidase inhibitory activity in some plants of North India

Samiksha

Sohal

2020

Heliyon

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In the present study, trypsin and chymotrypsin inhibitory activity of some plants of different families was evaluated. A total of 55 plants were screened, out of which six showed the maximum trypsin inhibitory activity namely Acacia concinna, Caesalpinia bonducella, Lathyrus sativus, Mucuna pruriens, Psoralea corylifolia and Sapindus mukorossi . Results suggested that the plants showing trypsin inhibitory activity (TIA) also have chymotrypsin inhibitory activity (CIA). Both trypsin and chymotrypsin inhibitory activities were high in seeds compared to leaves followed by flowers. It was also observed that TIA was maximally present in Sapindaceae family whereas CIA was maximum in fabaceae family followed by others.

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“…Though the activity of (28) was adjudged good, the comparison was done at a very high concentration (20 mg/kg) of the test compound as against glibenclamide (0.3 mg/kg). In another in vivo multiple dose (15 and 30 mg/kg for 30 days) antidiabetic study of an ethyl acetate sub-fraction of an ethanol extract of the bark of Pterospermum acerifolium from which (28) was isolated, the authors reported good activity at 30 mg/kg of the fraction as against 0.6 mg/kg of STD drug used in the study (Rathinavelusamy et al 2014 ). It was not clear to us what the STD drug was in the article.…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

“…It was not clear to us what the STD drug was in the article. Rathinavelusamy et al 2014 after isolating (28) from the most active fraction of Pterospermum acerifolium conducted an in silico antidiabetic study to determine the inhibitory activity of (28) against the human pancreatic α-amylase (HPA). They revealed free binding energy and inhibition constant (K i ) of − 8.39 kcal/mol and 0.269 µmol for (28) , and -6.07 kcal/mol and 28.52 µmol for the reference drug, acarbose, and they presented (28) as a potential HPA inhibitor when compared to acarbrose (Rathinavelusamy et al 2014 ).…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

Linking phytochemistry to traditional uses and pharmacology of an underexplored genus – Psydrax: a review

2022

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The genus Psydrax is one of the ethno-medicinally important genera of the Rubiaceae family which has only received a limited scientific attention, despite coming from a pharmacologically and phytochemically important plant family. The genus has found applications in ethnomedical management of diabetes, stomach disorders, inflammations, cardiovascular diseases, epilepsy, wounds, malaria and fever. To unveil knowledge gaps, stimulate research interest and unravel opportunities for drug discovery from the genus Psydrax , we have carried out an extensive review on its traditional applications, phytochemistry and pharmacology for the first time. Literature on these topics was obtained from Google Scholar, Pubmed and ScienceDirect journal articles published from 1788 to September, 2021. Only articles written in English were reviewed. While several species of Pysdrax used in traditional medicine have not been chemically explored for drug discovery, over a hundred secondary metabolites have so far been identified in few species of the genus, and majority of these chemotaxonomic markers are iridoids. Bioactive extracts and some isolated constituents of Psydrax species have shown various in vitro and in vivo pharmacological properties including anti-hyperglycemia, anti-inflammatory, anticonvulsant and antimicrobial, and thus, support some of the ethnomedical uses of the plants. For an evidence-informed application of the genus, Psydrax , in traditional medicine, more ethnobotanical surveys, elaborate in vivo pharmacological assays, in-depth toxicity and holistic phytochemical studies are required to fully exploit more species of the genus prior to future clinical studies. Following documented traditional uses of Psydrax species, the deliberate cultivation of medicinal plants under this genus is recommended for sustainability in medicinal plant utilization.

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Evaluation ofin silico, in vitroα-amylase inhibition potential and antidiabetic activity ofPterospermum acerifoliumbark

Abstract: The present study confirmed the antihyperglycemic activity along with its status on hepatic biomarkers, antihyperlipidemic and antioxidant properties of Pterospermum acerifolium bark.

Cited by 6 publications

References 20 publications

Alpha-amylase inhibitory activity and sterol composition of the marine algae, Sargassum glaucescens

Alpha-amylase inhibitory activity and sterol composition of the marine algae, Sargassum glaucescens

In vitro screening of peptidase inhibitory activity in some plants of North India

Linking phytochemistry to traditional uses and pharmacology of an underexplored genus – Psydrax: a review

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