Evaluation of <i>Geum urbanum</i> L. Extracts with Respect to Their Antimicrobial Potential

Bunse, Marek; Mailänder, Lilo K.; Lorenz, Peter; Stintzing, Florian C.

doi:10.1002/cbdv.202100850

Cited by 5 publications

(2 citation statements)

References 55 publications

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“…The MIC values for the methanolic extracts of G. urbanum were higher than those obtained in our experiment. In addition, ethyl acetate and butanol extracts of fresh and dried G. urbanum roots showed a marked inhibitory effect on S. aureus after placing 0.6 mg extract on the disc [72]. In turn, the E. faecalis strain was the most sensitive to the aqueous ethanolic extract of G. urbanum, with an MIC value of 0.0625 mg/mL.…”

Section: Antibacterial Activitymentioning

confidence: 96%

Antioxidant and Antibacterial Activity of Extracts from Selected Plant Material

et al. 2022

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Plants are a valuable source of biologically active molecules, mainly phenolic compounds. In the present study, the total phenolic content (TPC), DPPH· and ABTS+ scavenging activity as well as ferric reducing ability (FRAP) of aqueous ethanolic (70%) extracts of Cistus incanus L. and Asarum europaeum L. herb, Geum urbanum L. rhizome, Angelica archangelica L. root, white mulberry (Morus alba L.), lemon balm (Melisa officinalis L.), red raspberry (Rubus idaeus L.) and Betula pendula Roth. leaves were determined. In addition, the phenolic profiles of the studied plant extracts and antibacterial activity have been investigated. The extracts from C. incanus and G. urbanum demonstrated the highest TPC and antioxidant capacity, while the extracts from A. archangelica and white mulberry were characterized by the lowest values. A remarkable correlation was also found between the TPC and antioxidant activity of the examined extracts. HPLC analysis showed that the studied extracts were sources of both phenolic acids and flavonoids. More flavonoids than phenolic acids were identified in the extracts of C. incanus, M. alba, R. idaeus and B. pendula compared to the other extracts tested. Not all extracts showed a significant impact on the growth of the tested bacterial strains. Escherichia coli was the most sensitive strain to lemon balm extract (MIC, 0.125 mg/mL), whereas the strains of Acinetobacter baumannii and Bordetella bronchiseptica were sensitive to the G. urbanum extract (MIC, 0.125 mg/mL). Among Gram-positive bacteria, Enterococcus faecalis was the most sensitive to G. urbanum extract. In turn, Staphylococcus aureus and Staphylococcus epidermidis were sensitive to the extracts from C. incanus herb (MIC, 0.125 mg/mL), red raspberry (MIC, 0.125 mg/mL) and lemon balm leaves (MIC. 0.25 mg/mL). Based on the obtained results, the applicability of the studied plant extracts as additives to food and cosmetic products may be considered in the future.

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Section: Antibacterial Activitymentioning

confidence: 96%

Antioxidant and Antibacterial Activity of Extracts from Selected Plant Material

et al. 2022

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“…In the last decade, it has become particularly evident that the skin microbiome not only influences skin appearance and disease (e.g., acne) but is also linked to the gut microbiome and plays a major role in immune defense ( Beri, 2018 ; Nakouti et al, 2022 ). EOs and other natural MOCS can be used to rebalance the skin microbiome and the resulting clinical picture, promoting a healthy skin microbiology ( Han et al, 2017 ; Wallen-Russell and Wallen-Russell, 2017 ; Białoń et al, 2019 ; Bunse et al, 2022 ).…”

Section: Therapeutic Uses Of Eosmentioning

confidence: 99%

Essential Oils as Multicomponent Mixtures and Their Potential for Human Health and Well-Being

et al. 2022

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Essential oils (EOs) and their individual volatile organic constituents have been an inherent part of our civilization for thousands of years. They are widely used as fragrances in perfumes and cosmetics and contribute to a healthy diet, but also act as active ingredients of pharmaceutical products. Their antibacterial, antiviral, and anti-inflammatory properties have qualified EOs early on for both, the causal and symptomatic therapy of a number of diseases, but also for prevention. Obtained from natural, mostly plant materials, EOs constitute a typical example of a multicomponent mixture (more than one constituent substances, MOCS) with up to several hundreds of individual compounds, which in a sophisticated composition make up the property of a particular complete EO. The integrative use of EOs as MOCS will play a major role in human and veterinary medicine now and in the future and is already widely used in some cases, e.g., in aromatherapy for the treatment of psychosomatic complaints, for inhalation in the treatment of respiratory diseases, or topically administered to manage adverse skin diseases. The diversity of molecules with different functionalities exhibits a broad range of multiple physical and chemical properties, which are the base of their multi-target activity as opposed to single isolated compounds. Whether and how such a broad-spectrum effect is reflected in natural mixtures and which kind of pharmacological potential they provide will be considered in the context of ONE Health in more detail in this review.

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Biosynthesis of Silver and Gold Nanoparticles Using Geum urbanum L. Rhizome Extracts and Their Biological Efficiency

Macovei,

Harabagiu,

Burlec

et al. 2024

J Inorg Organomet Polym

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The present study evaluates the biosynthesis of AgNPs and AuNPs using aqueous and ethanolic Geum urbanum L. rhizome extracts. The biosynthesized metal nanoparticles (MNPs) were characterized using UV-Vis spectroscopy, FTIR, DLS, SEM, EDX, and TEM. The UV-Vis spectra confirmed the synthesis of AgNPs and AuNPs through peaks corresponding to the surface plasmon effect of metallic Ag (400–430 nm) and Au (530–570 nm). FTIR analysis indicated that alcohols, phenols, proteins, and carbohydrates from G. urbanum rhizome extracts composition are involved in MNPs synthesis. In DLS analysis, AgNPs (34.26–41.14 nm) showed smaller hydrodynamic diameters than AuNPs (46.26–70.29 nm). At the same time, all values for zeta potential were negative, between − 21 and − 13 mV, suggesting good stabilities for all the colloidal MNPs systems in dispersion. TEM analysis showed that the biosynthesized AgNPs had a spherical morphology, while AuNPs were quasi-spherical, polygonal, and triangular. According to TEM data, AgNPs synthesized using aqueous and ethanolic G. urbanum rhizome extracts were characterized by mean diameters of 9.82 ± 3.68 and 14.29 ± 3.46 nm, while AuNPs by 15.88 ± 6.28 and 24.89 ± 10.75 nm, respectively. EDX analysis confirmed the presence of metallic Ag and Au in the MNPs composition by detecting strong signals at 3 (AgNPs) and 2.2 keW (AuNPs). In disc diffusion assay, MNPs showed good antimicrobial activity against Gram-positive (S. aureus MSSA, S. aureus MRSA, S. epidermidis) and Gram-negative (E. coli, P. aeruginosa, K. pneumoniae) bacteria and yeasts (C. albicans). AgNPs and AuNPs were also characterized by a significant antioxidant potential, evaluated through in vitro assays (lipoxygenase inhibition, DPPH radical scavenging activity, metal ion chelating activity, and hydroxyl radical scavenging assays). An overall better activity was obtained for the ethanolic G. urbanum rhizome extract and its derived AgNPs (EC50 = 34.2 ± 1.86 mg/mL in lipoxygenase inhibition assay). Therefore, the G. urbanum rhizome extracts proved to be excellent sources for biologically active AgNPs and AuNPs.

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Evaluation of Geum urbanum L. Extracts with Respect to Their Antimicrobial Potential

Cited by 5 publications

References 55 publications

Antioxidant and Antibacterial Activity of Extracts from Selected Plant Material

Antioxidant and Antibacterial Activity of Extracts from Selected Plant Material

Essential Oils as Multicomponent Mixtures and Their Potential for Human Health and Well-Being

Biosynthesis of Silver and Gold Nanoparticles Using Geum urbanum L. Rhizome Extracts and Their Biological Efficiency

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