Evaluation of<i>Antiaris africana</i>methanol extract and compounds for antioxidant and antitumor activities

Kuete, Victor; Vouffo, Bertin; Mbaveng, Armelle T.; Vouffo, Edwige Ymele Chiogo; Siagat, R.; Dongo, Étienne

doi:10.3109/13880200902988595

Cited by 33 publications

(19 citation statements)

References 22 publications

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“…Meanwhile, the anticancer properties of 3,3’-dimethoxy-4’- O -β-D-xylopyronosylellagic acid (93) from Antiaris africana (a plant traditionally used to treat cancer, amongst other ailments), has been verified. This compound indicated a pronounced tumor reducing activity (96.64%) in potato disk tumor induction assay and also showed interesting inhibitory properties against human DU-145 and hepatocarcinoma Hep G2 cells with > 70% inhibition at 50 μg/mL [94]. At the same time, the ceramide tanacetamide (113), with an interesting vasorelaxant property, was isolated along with salvin A and maslinic acid from Vitex cienkowskii , thus validating the use of the plant in the treatment of cardiovascular diseases [100].…”

Section: Resultsmentioning

confidence: 99%

Cameroonian medicinal plants: a bioactivity versus ethnobotanical survey and chemotaxonomic classification

Ntie‐Kang

Lifongo

Mbaze

et al. 2013

BMC Complement Altern Med

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BackgroundIn Cameroon herbs are traditionally used to meet health care needs and plans are on the way to integrate traditional medicine in the health care system, even though the plans have not been put into action yet. The country however has a rich biodiversity, with ~8,620 plant species, some of which are commonly used in the treatment of several microbial infections and a range of diseases (malaria, trypanosomiasis, leishmaniasis, diabetes and tuberculosis).MethodsOur survey consisted in collecting published data from the literature sources, mainly from PhD theses in Cameroonian university libraries and also using the author queries in major natural product and medicinal chemistry journals. The collected data includes plant sources, uses of plant material in traditional medicine, plant families, region of collection of plant material, isolated metabolites and type (e.g. flavonoid, terpenoid, etc.), measured biological activities of isolated compounds, and any comments on significance of isolated metabolites on the chemotaxonomic classification of the plant species. This data was compiled on a excel sheet and analysed.ResultsIn this study, a literature survey led to the collection of data on 2,700 secondary metabolites, which have been previously isolated or derived from Cameroonian medicinal plants. This represents distinct phytochemicals derived from 312 plant species belonging to 67 plant families. The plant species are investigated in terms of chemical composition with respect to the various plant families. A correlation between the known biological activities of isolated compounds and the ethnobotanical uses of the plants is also attempted. Insight into future direction for natural product search within the Cameroonian forest and Savanna is provided.ConclusionsIt can be verified that a phytochemical search of active secondary metabolites, which is inspired by knowledge from the ethnobotanical uses of medicinal plants could be very vital in a drug discovery program from plant-derived bioactive compounds.

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Section: Resultsmentioning

confidence: 99%

Cameroonian medicinal plants: a bioactivity versus ethnobotanical survey and chemotaxonomic classification

Ntie‐Kang

Lifongo

Mbaze

et al. 2013

BMC Complement Altern Med

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“…Africanoside effected a concentration-dependent inhibition of tumor cell growth with a mean IC 50 value of 5.3 nM. 20,21 Amoora rohituka Amooranin (AMR), a triterpene acid isolated from the petroleum ether, dichloromethane, and ethanol fraction of stem bark of Amoora rohituka (Meliaceae). The mechanism of cell death associated with AMR cytotoxicity in human mammary carcinoma MCF-7, multidrug resistant breast carcinoma MCF-7/TH and breast epithelial MCF-10A cell lines.…”

Section: Antiaris Africanamentioning

confidence: 99%

Medicinal Plants for Treatment of Cancer: A Brief Review

Jain¹,

Dwivedi²,

Jain³

et al. 2016

phcogj

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“…Nas figuras 1 e 2 são mostrados os perfis cromatográficos para o óleo das flores e cascas respectivamente. (KUETE et al, 2010;SARTORATTO et al, 2004 et al,2010). Em um trabalho realizado por HARRIS e colaboradores, (2003) reporta que devido à natureza lipídica dos compostos terpênicos que estão presentes no óleo, resulta em um transporte melhor do antibiótico para dentro da célula bacteriana, alterando a permeabilidade da membrana citoplasmática.…”

Section: Resultsunclassified

Composição Química Do Óleo Essencial Da Ocotea Diospyrifolia (Mez) (Lauraceae) E Ação Sinérgica / Chemical Composition of Ocotea Diospyrifolia Essential Oil (Mez) (Lauraceae) and Synergistic Action

Santos

Mallmann

Silva

et al. 2020

BJD

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Evaluation ofAntiaris africanamethanol extract and compounds for antioxidant and antitumor activities

Cited by 33 publications

References 22 publications

Cameroonian medicinal plants: a bioactivity versus ethnobotanical survey and chemotaxonomic classification

Cameroonian medicinal plants: a bioactivity versus ethnobotanical survey and chemotaxonomic classification

Medicinal Plants for Treatment of Cancer: A Brief Review

Composição Química Do Óleo Essencial Da Ocotea Diospyrifolia (Mez) (Lauraceae) E Ação Sinérgica / Chemical Composition of Ocotea Diospyrifolia Essential Oil (Mez) (Lauraceae) and Synergistic Action

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