Evaluation of hypolipidemic Marrubium vulgare effect in Triton WR-1339-induced hyperlipidemia in mice

Ibrahim, Abeer Y.; Hendawy, Saber F.; El-Sayed, Ahmed A.; Omer, Elsayed A.

doi:10.1016/j.apjtm.2016.03.038

Cited by 20 publications

(16 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…After 7 h and 24 h of treatment, the intragastric administration of all extracts caused a significant decrease of plasma total cholesterol; LDL cholesterol and triglyceride levels were also significantly lowered by all extracts. Additionally, more polar extracts (methanol and ethyl acetate) showed a significant ameliorative action on elevated atherogenic index (AI) and LDL/HDL-C ratios [ 95 ]. These findings coincide with recorded decreases in the total cholesterol and LDL cholesterol levels during antidiabetic studies, which was probably due to a stimulation of the insulin secretion [ 86 ].…”

Section: Applications In Medicine and As Pesticidesmentioning

confidence: 99%

Marrubium vulgare L.: A Phytochemical and Pharmacological Overview

et al. 2020

View full text Add to dashboard Cite

Marrubium vulgare is a plant with high bioactive potential. It contains marrubiin, a labdane diterpene that is characteristic for this genus, as well as a complex mixture of phenolic compounds. According to numerous studies, M. vulgare acts as a good antioxidant agent, and due to this, it could potentially be useful in treatments of cancer, diabetes mellitus, and liver diseases. In addition, its anti-inflammatory, wound-healing, antihypertensive, hypolipidemic, and sedative potential are discussed. Apart from that, its antimicrobial activity, especially against Gram+ bacteria, fungi, herpes simplex virus, and parasites such as Toxoplasma gondii, Trichomonas vaginalis, and Plasmodium berghei-berghei was recorded. Additionally, it could be used as a chicken lice repellent, herbicide, and natural insecticide against mosquito larvae and natural molluscicide. In veterinary medicine, M. vulgare can be used as an anthelmintic against the eggs and larvae of bovine strongyles parasites, and as an antibiotic against bovine mastitis caused by resistant bacterial strains. Due to the mentioned benefits, there is a tendency for the cultivation of M. vulgare in order to ensure high-quality raw material, but more firm scientific evidence and well-designed clinical trials are necessary for the well-established use of M. vulgare herb and its preparations.

show abstract

Section: Applications In Medicine and As Pesticidesmentioning

confidence: 99%

Marrubium vulgare L.: A Phytochemical and Pharmacological Overview

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The antioxidant activities of SEO and vitamin C, used as a standard, were evaluated by the method of Gülçin, Oktay, Kirecci, and Küfreviŏglu (2003) modified by Abeer, Saber, Ahmed, and Elsayed (2016). The absorbance of peroxide was read at 500 nm.…”

Section: Lipid Peroxidationmentioning

confidence: 99%

The protective effects ofSalvia officinalisessential oil compared to simvastatin against hyperlipidemia, liver, and kidney injuries in mice submitted to a high‐fat diet

et al. 2020

View full text Add to dashboard Cite

The present study was undertaken to evaluate the effects of Salvia officinalis essential oil (SEO) and simvastatin in hyperlipidemic mice. Animals were randomly divided into four groups. The control group received a standard diet. The high‐fat diet (HFD) group received HFD. The third and fourth groups received HFD associated either with simvastatin (2.5 mg/kg bw) or with SEO (4 mg/kg bw). All animals were sacrificed after 8 weeks of treatment. SEO and simvastatin reduced in HFD mice body weight gain, hyperlipidemia, disruption of liver and renal functions and reactive oxygen species production. In fact, total cholesterol, triglycerides, total lipids, and low‐density lipoprotein cholesterol levels, as well as aspartate transaminase, alanine transaminase, gamma‐glutamyltranspeptidase and lactate dehydrogenase activities were reduced, while fecal lipids increased compared to those of HFD mice. The lipid‐lowering effect of SEO was more effective than that of simvastatin. Practical applications High‐fat diet provokes hyperlipidemia, atherosclerosis, and abnormal lipid metabolism leading to the development of hepatic and renal dysfunctions as well as perturbations of the antioxidant status in liver and kidney. The results of this research highlight the beneficial effects of SEO in the management of these disorders without inducing side effects; in fact, the plant essential oil decreased lipids and improved the antioxidant status more than did a synthetic drug.

show abstract

“…Atherosclerosis and hyperlipidemia have been found as major factor for cerebrovascular diseases, coronary artery diseases and peripheral vascular diseases. 22,23 Poloxamer-407 treated DI animals exhibited increased body weight. OZS animals exhibited comparatively normal body weight.…”

Section: Discussionmentioning

confidence: 94%

Effect of γ-oryzanol on hyperlipidemia and thrombus formation in mice treated with poloxamer-407

Panchal¹,

Bhatt²,

Mishra³

et al. 2018

Pol. Ann. Med.

View full text Add to dashboard Cite

Evaluation of hypolipidemic Marrubium vulgare effect in Triton WR-1339-induced hyperlipidemia in mice

Abstract: The findings indicated that Marrubium may contain polar products able to lower plasma lipid concentrations and might be beneficial in treatment of hyperlipidemia and atherosclerosis.

Cited by 20 publications

References 33 publications

Marrubium vulgare L.: A Phytochemical and Pharmacological Overview

Marrubium vulgare L.: A Phytochemical and Pharmacological Overview

The protective effects ofSalvia officinalisessential oil compared to simvastatin against hyperlipidemia, liver, and kidney injuries in mice submitted to a high‐fat diet

Effect of γ-oryzanol on hyperlipidemia and thrombus formation in mice treated with poloxamer-407

Contact Info

Product

Resources

About