Evaluation of hypoglycemic effect of Morus alba in an animal model

Abstract

Objective:The objective of the present investigation was to evaluate the therapeutic efficacy of mulberry leaves in an animal model of diabetes.Materials and Methods:Animals were treated with mulberry leaf extract 400 mg and 600 mg/kg body weight for 35 days. Blood glucose, glycosylated hemoglobin, triglyceride, LDL, VLDL, HDL, blood urea, cholesterol, number of β cells, and diameter of the islets of Langerhans were measured at the beginning and at the end of the experiment.Results:Blood glucose level and other parameters (except HDL) were elevated in the diabetic group, but were brought to control group level in the diabetic group treated with 600 mg/kg body weight of mulberry leaf extract. The diameter of the islets and the number of β cells were reduced in the diabetic group; both parameters were brought to control group level after treatment with mulberry leaf extract.Conclusion:Mulberry leaf extract, at a dose of 600 mg/kg body weight, has therapeutic effects in diabetes-induced Wistar rats and can restore the diminished β cell numbers.

Mulberry leaves and their potential effects against cardiometabolic risks: a review of chemical compositions, biological properties and clinical efficacy

“…This indicated that mulberry leaves could be effective to improve glycaemic control and reverse insulin resistance. Moreover, histological examination showed that mulberry leaves treatment restored the size and number of pancreatic β-cells of diabetic animals closely to the baseline levels (Mohammadi and Naik 2008 ).…”

“… 2011 ). Meanwhile, long-term mulberry leaves ingestion tended to normalize the levels of fasting plasma glucose (FPG), glycated haemoglobin (HbA1c), fructosamine and insulin indexes of diabetic animals to nearly normal values (Mohammadi and Naik 2008 ; Park et al. 2009 ; Kim JY et al.…”

Evaluation of a Standardized Extract from Morus alba against α‐Glucosidase Inhibitory Effect and Postprandial Antihyperglycemic in Patients with Impaired Glucose Tolerance: A Randomized Double‐Blind Clinical Trial

“…In addition, in the acute toxicity evaluation, no toxicity was observed. M. alba extracts have been previously reported to have antihyperglycemic effect in STZ-induced diabetic rats [27] and in diet-induced obese mice [28] and to block inflammatory response in STZ-diabetic mice model [29] and in STZ-induced diabetic rats fed high-fat diet [30]. Among them, Jeszka-Skowron et al have reported that DNJ may suggest additional roles in the gut to reduce or inhibit intestinal glucose digestion and absorption [30].…”

A review study on phytochemistry and pharmacology applications of Juglans Regia plant

“…[ 28 ] Previous research also indicates that polysaccharides, flavonoids, polypeptides, steroids, alkaloids, and pectin in the medicinal plants can well justify the blood glucose, and cholesterol lipid lowering properties of some herbs in the treatment of diabetes by preventing the blood biochemical changes. [ 26 29 60 61 ]…”

“…[ 16 17 30 ] The results of previous studies shown that walnut administration would change the distribution of lipids in different lipoprotein groups; and the use of walnuts is likely associated with anti-atherogenic effects. [ 60 61 62 63 ]…”