Evaluation of hypocholesterolemic effect and antioxidant activity of Boops boops proteins in cholesterol-fed rats

Abstract

Dietary proteins affect blood cholesterol concentrations and antioxidant status, which are related to several diseases, including cardiovascular disease. The present study attempts to investigate the potential of Boops boops proteins (Bb-NHP) and its hydrolysate (Bb-HP) in the prevention of hypercholesterolemia and oxidative stress in rats fed a high cholesterol diet (HCD). After four weeks' treatment, serum lipid profiles (total cholesterol, triglycerides, HDL-cholesterol and LDL-cholesterol), the activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), the level of malonaldehyde (MDA) and the activities of antioxidant enzymes [catalase (CAT) and glutathione peroxidase (GPx)] in liver were determined. Compared with those fed a standard diet, high cholesterol diet induced dyslipidemia, oxidative stress, and aortic structure alterations. Interestingly, supplementing the HCD with Boops boops proteins attenuated these anomalies in a dose-dependent manner. These observations suggested that B. boops proteins might provide health benefits by helping to reduce the deleterious effects of increased intake of cholesterol that characterize modern diets.

Hypolipidemic, antiobesity and cardioprotective effects of sardinelle meat flour and its hydrolysates in high-fat and fructose diet fed Wistar rats

“…Further, oral administration of Fluv and FSPHs increased the HDL-c levels compared to the corresponding values of HCD group and the value obtained were even higher than that of control group. Similar results were also reported by Lassoued et al [11] with protein hydrolysates from Boops boops and Ktari et al [10] with protein hydrolystes from Salaria bascilisca. Ben Khaled et al [9] also reported that sardinelle protein hydrolysates obtained by enzymatic hydrolysis help to balance the serum lipid profile in rats fed a high-fat diet.…”

“…Several works have reported the importance of dietary proteins and protein hydrolysates in the regulation of cholesterol metabolism [9,10,11]. To date, hypocholesterolemic properties have been reported for soy [12] and whey [13].…”

Antihyperlipidemic and antioxidant effects of feather protein hydrolysate in high‐fat diet‐fed mice

“…Interestingly, when hyperlipidemic mice were supplemented with FPH, these activities decreased and became comparable to the control group. Similar findings were observed in previous studies showing the hepatoprotective effects of protein hydrolysates on hypercholesteromic rats [20].…”

Sardina pilchardus and Sardinella aurita protein hydrolysates reduce cholesterolemia and oxidative stress in rat fed high cholesterol diet

“…We have previously demonstrated that hypercholesterolemia was associated with the deterioration of antioxidant status, resulting from increased MDA levels and decreased antioxidant enzyme activity [36]; in our experimental design, we studied whether deterioration of antioxidant status associated with hypercholesterolemia was corrected by fish protein hydrolysates. In the present study, results showed that sardine and particularly sardinelle decreased TBARS and hydroperoxides in serum.…”