Evaluation of hydrogen peroxide gaseous disinfection systems to decontaminate viruses

Pottage, Thomas; Richardson, Chad L.; Parks, Simon; Walker, James T.; Bennett, Allan

doi:10.1016/j.jhin.2009.08.020

Cited by 111 publications

(84 citation statements)

References 17 publications

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“…No significant inactivation was observed even after 10 min of contact with these compounds in solution. These results are not surprising for two reasons: first of all, the ability to survive exposure to gastric acidity would be a useful evolutionary development for a foodborne virus (Baert et al 2009a) and second, previous studies have already demonstrated that hydrogen peroxide is an effective virucide only at concentrations higher than 10 g L -1 and therefore is less potent than PAA (Eterpi et al 2009;Li et al 2011;Pottage et al 2010). It is worth noting that despite their weak activity, both the acid and hydrogen peroxide are likely essential for the activity of the peroxyacid.…”

Section: Discussionmentioning

confidence: 79%

Study of the Virucidal Potential of Organic Peroxyacids Against Norovirus on Food-Contact Surfaces

2014

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This study was conducted to evaluate the efficacy of four different peroxyacids, namely peracetic (PAA), perpropionic (PPA), perlactic (PLA), and percitric (PCA) for inactivating viruses in suspension or attached to stainless steel or polyvinyl chloride surfaces. The test virus was a proxy for human norovirus, namely murine norovirus 1. Plaque-forming units in suspension (10(7) per mL) were treated with 50-1,000 mg L(-1) peroxyacid (equilibrium mixture of organic acid, hydrogen peroxide, peroxyacid, and water) for 1-10 min. Inactivation was measured by plaque assay. PAA and PPA were the most effective, with a 5 min treatment at 50 mg L(-1) being sufficient to reduce viral titer by at least 3.0 log10, whether the virus was in suspension or attached to stainless steel or polyvinyl chloride disks under clean or fouled conditions. Combinations of organic acid and hydrogen peroxide were found ineffective. Similar inactivation was observed in the case of virus in artificial biofilm (alginate gel). These short super-oxidizers could be used for safe inactivation of human noroviruses in water or on hard surfaces.

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Section: Discussionmentioning

confidence: 79%

Study of the Virucidal Potential of Organic Peroxyacids Against Norovirus on Food-Contact Surfaces

2014

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“…However, inactivation of B. atrophaeus spores required overnight exposure in the presence of soil load. Other laboratory fumigation agents such as VHP, formaldehyde, and gaseous chlorine dioxide (GCD) have varying degrees of soil load tolerance (Casella & Schmidt-Lorenz, 1989;Julie et al, 2011;Koen & Frank, 2011;Meszaros, 2005;Pottage et al, 2010). Among them, GCD appears to tolerate soil load best (Krishnan et al, 2006b).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of a Dry Fogging System for Laboratory Decontamination

et al. 2012

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“…This retention of viability in a small subsection of spores that remain resistant to gaseous disinfectants is a phenomenon known as "trailing" (33). Various explanations for this include: (i) the presence of a subpopulation of hyper-resistant spores, (ii) the occlusion of spores by layering or other factors, and/or (iii) the possibility of cross-contamination.…”

Section: Discussionmentioning

confidence: 99%

Low-Temperature Decontamination with Hydrogen Peroxide or Chlorine Dioxide for Space Applications

Pottage¹,

Macken²,

Giri³

et al. 2012

Appl Environ Microbiol

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ABSTRACTThe currently used microbial decontamination method for spacecraft and components uses dry-heat microbial reduction at temperatures of >110°C for extended periods to prevent the contamination of extraplanetary destinations. This process is effective and reproducible, but it is also long and costly and precludes the use of heat-labile materials. The need for an alternative to dry-heat microbial reduction has been identified by space agencies. Investigations assessing the biological efficacy of two gaseous decontamination technologies, vapor hydrogen peroxide (Steris) and chlorine dioxide (ClorDiSys), were undertaken in a 20-m3exposure chamber. Five spore-formingBacillusspp. were exposed on stainless steel coupons to vaporized hydrogen peroxide and chlorine dioxide gas. Exposure for 20 min to vapor hydrogen peroxide resulted in 6- and 5-log reductions in the recovery ofBacillus atrophaeusandGeobacillus stearothermophilus, respectively. However, in comparison, chlorine dioxide required an exposure period of 60 min to reduce bothB. atrophaeusandG. stearothermophilusby 5 logs. Of the three otherBacillusspp. tested,Bacillus thuringiensisproved the most resistant to hydrogen peroxide and chlorine dioxide with D values of 175.4 s and 6.6 h, respectively. Both low-temperature decontamination technologies proved effective at reducing theBacillusspp. tested within the exposure ranges by over 5 logs, with the exception ofB. thuringiensis, which was more resistant to both technologies. These results indicate that a review of the indicator organism choice and loading could provide a more appropriate and realistic challenge for the sterilization procedures used in the space industry.

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Evaluation of hydrogen peroxide gaseous disinfection systems to decontaminate viruses

Cited by 111 publications

References 17 publications

Study of the Virucidal Potential of Organic Peroxyacids Against Norovirus on Food-Contact Surfaces

Study of the Virucidal Potential of Organic Peroxyacids Against Norovirus on Food-Contact Surfaces

Evaluation of a Dry Fogging System for Laboratory Decontamination

Low-Temperature Decontamination with Hydrogen Peroxide or Chlorine Dioxide for Space Applications

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