Evaluation of hydrocortisone as a strain-dependent growth-regulator of Porphyromonas gingivalis

Klomp, Tim; Jahr, Holger; Abdelbary, Mohamed M. H.; Conrads, Georg

doi:10.1016/j.anaerobe.2023.102698

Cited by 1 publication

(1 citation statement)

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“…In line with this, we found that Epi-treated bacteria were more resistant to antibiotics, SDS, H 2 O 2 , and ethanol (Figure 5), of which the mechanisms need to be further investigated. Moreover, we observed this phenomenon in attenuated the M. tuberculosis H37Ra strain, and this phenomenon may be different in different strains [39]. Our data suggest that the application of quorumsensing inhibitors to increase biofilm susceptibility to antibiotics may be a potential strategy to address Epi-induced M. tuberculosis biofilm formation.…”

Section: Discussionmentioning

confidence: 62%

Epinephrine Stimulates Mycobacterium tuberculosis Growth and Biofilm Formation

Lei,

Rahman,

Cao

et al. 2023

IJMS

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The human stress hormones catecholamines play a critical role in communication between human microbiota and their hosts and influence the outcomes of bacterial infections. However, it is unclear how M. tuberculosis senses and responds to certain types of human stress hormones. In this study, we screened several human catecholamine stress hormones (epinephrine, norepinephrine, and dopamine) for their effects on Mycobacterium growth. Our results showed that epinephrine significantly stimulated the growth of M. tuberculosis in the serum-based medium as well as macrophages. In silico analysis and molecular docking suggested that the extra-cytoplasmic domain of the MprB might be the putative adrenergic sensor. Furthermore, we showed that epinephrine significantly enhances M. tuberculosis biofilm formation, which has distinct texture composition, antibiotic resistance, and stress tolerance. Together, our data revealed the effect and mechanism of epinephrine on the growth and biofilm formation of M. tuberculosis, which contributes to the understanding of the environmental perception and antibiotic resistance of M. tuberculosis and provides important clues for the understanding of bacterial pathogenesis and the development of novel antibacterial therapeutics.

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Section: Discussionmentioning

confidence: 62%