Evaluation of hybrid liposomes-encapsulated silymarin regarding physical stability and in vivo performance

El-Samaligy, Mohamed S.; Afifi, Nagia N.; Mahmoud, E. A.

doi:10.1016/j.ijpharm.2006.04.023

Cited by 111 publications

(43 citation statements)

References 44 publications

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“…Our results clearly demonstrated the bioavailability of systemically administered silibinin (Zhao and Agarwal, 1999). Additionally, recent literature is abundant with the studies reporting different formulations with tested increased bioavailability using different animal models (Abrol et al, 2005;El-samaligy et al, 2006). A detailed study on the bioavailability and clinical efficacy in humans has been conducted with Silibinin Phytosome called as Siliphos (Kidd and Head, 2005).…”

Section: Milk Thistle Extract Silymarin and Silibinin: Pharmacology mentioning

confidence: 57%

Silymarin and epithelial cancer chemoprevention: How close we are to bedside?

Kaur

Agarwal

2007

Toxicology and Applied Pharmacology

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Failure and high systemic toxicity of conventional cancer therapies have accelerated the focus on the search for newer agents, which could prevent and/or slow-down cancer growth and have more human acceptability by being less or non-toxic. Silymarin is one such agent, which has been extensively used since ages for the treatment of liver conditions, and thus has possibly the greatest patient acceptability. In recent years, increasing body of evidence has underscored the cancer preventive efficacy of silymarin in both in vitro and in vivo animal models of various epithelial cancers. Apart from chemopreventive effects, other noteworthy aspects of silymarin and its active constituent silibinin in cancer treatment include their capability to potentiate the efficacy of known chemotherapeutic drugs, as an inhibitor of multidrug resistance associated proteins, and as an adjunct to the cancer therapeutic drugs due to their organ-protective efficacy specifically liver, and immunostimulatory effects. Widespread use of silymarin for liver health in humans and commercial availability of its formulations with increased bioavailability, further underscore the necessity of carrying out controlled clinical trials with these agents in cancer patients. In this review, we will briefly discuss the outcomes of clinical trials being conducted by us and others in cancer patients to provide insight into the clinical relevance of the observed chemopreventive effects of these agents in various epithelial cancer models.

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Section: Milk Thistle Extract Silymarin and Silibinin: Pharmacology mentioning

confidence: 57%

Silymarin and epithelial cancer chemoprevention: How close we are to bedside?

Kaur

Agarwal

2007

Toxicology and Applied Pharmacology

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“…Tissues were cleared in xylene and embedded in paraffin bees wax blocks and kept at 56°C for another 24 h. Sections from the paraffin blocks of 4 μm thickness were cut by sledge microtome, deparaffinized, and stained with hematoxyline and eosin (18). All sections were examined using an electric light microscope (Binuclear XS2-N107T, China).…”

Section: Histopathological Examinationmentioning

confidence: 99%

Enhancement of Bioavailability and Pharmacodynamic Effects of Thymoquinone Via Nanostructured Lipid Carrier (NLC) Formulation

et al. 2015

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Abstract. Thymoquinone (TQ), obtained from black cumin (Nigella sativa), is a natural product with antioxidant, anti-inflammatory, and hepatoprotective effects but unfortunately with poor bioavailability. Aiming to improve its poor oral bioavailability, TQ-loaded nanostructured lipid carriers (NLCs) were prepared by high-speed homogenization followed by ultrasonication and evaluated in vitro. Bioavailability and pharmacodynamic studies were also performed. The resultant NLCs showed poor physical homogeneity in Compritol 888 ATO Pluronic F127 system which consequently produced larger particle size and polydispersity index, smaller zeta potential values, and lower short-term (30 days) physical stability than other systems. Encapsulation efficiency percentage (EE%) lied between 84.6±5% and 96.2±1.6%. TQ AUC 0-t values were higher in animals treated with NLCs, with a relative bioavailability of 2.03-and 3.97-fold (for F9 and F12, respectively) higher than TQ suspension, indicating bioavailability enhancement by NLC formulation. Hepatoprotective effects of F12 showed significant (P<0.05) decrease in both serum alanine amino transferase and aspartate amino transferase to reach 305.0±24.88 and 304.7±23.55 U/ml, respectively, when compared with untreated toxic group. Anti-oxidant efficacy of F12 showed significant (P<0.05) decline of malondialdehyde and elevation of reduced glutatione. This improvement was also confirmed histopathologically.

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“…These are spherical in shape and can be formulated using cholesterol and natural phospholipids. [51,52] Liposomes are also preferred to be an advanced delivery system for nutraceutical products. Intranasal quercetin liposomes is one of the examples which have been reported to enhance the penetration of quercetin through blood brain barriers and increase the therapeutic anticancer efficacy of the product.…”

Section: Liposomesmentioning

confidence: 99%

Untitled

Sharma¹

2017

IJGP

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The term "nutraceuticals" can be explained as the food items as a whole or a part which possesses some nutritional value along with the medicinal properties. This special feature, besides providing good health, leads to treatment and prevention of certain diseases. With the advancements in the qualitative and quantitative determining parameters, the requisition of these products has been found to be amplified. Due to this, the nutraceutical market has become a million dollar industry at a global level. The era of emergence of nutrients as medicines in the pharmaceutical world is of great importance and draws attention of scientists and researchers toward the appreciable benefits. The history and discovery has explored many facts about the remarkably profound therapeutic activities of such agents. As a result, interdisciplinary approaches are now been applied to design and develop various dosage forms to deliver these herbal products relative to their applications. The extensive researches have revealed the involvement of these agents in the treatment of many disorders such as cancer, arthritis, metabolic abnormalities, diabetes, asthma, and many others. The presented review is an attempt to classify all types of nutraceuticals with examples followed by their applications in the treatment of various disorders. Furthermore, the implementation of the designing and development of dosage forms for offering better delivery carrier of the nutraceuticals, the importance and challenges have also been enumerated.

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Evaluation of hybrid liposomes-encapsulated silymarin regarding physical stability and in vivo performance

Cited by 111 publications

References 44 publications

Silymarin and epithelial cancer chemoprevention: How close we are to bedside?

Silymarin and epithelial cancer chemoprevention: How close we are to bedside?

Enhancement of Bioavailability and Pharmacodynamic Effects of Thymoquinone Via Nanostructured Lipid Carrier (NLC) Formulation

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