Evaluation of hyaluronic matrix efficacy in sinus augmentation: a randomized-controlled histomorphometric and micro–computed tomography analysis

Do osteoconductive bone substitutes result in similar bone regeneration for maxillary sinus augmentation when compared to osteogenic and osteoinductive bone grafts? A systematic review and frequentist network meta-analysis

“…For the outcome of overall NBF, the total sample consisted of 1483 biopsies in 52 RCTs on MSA . The grafting materials were AB alone (n = 16 trials; 215 biopsies) 37,39,41,43,44,52,54,58,65,68,71,73,76,80,81,83 , AG alone (n = 6 trials; 78 biopsies) 47,49,57,73,74,83 , XG alone (n = 27 trials; 365 biopsies) 36,38,42,43,45,46,[48][49][50][51]53,55,56,59,60,[62][63][64]66,67,73,75,[77][78][79]82,85 , AP alone (n = 19 trials, 263 biopsies) 35,…”

“…For the mean percentage NBF with a healing time <6 months (range 3-5 months), a total of 645 biopsies in 19 RCTs consisting of 10 groups were included 35,37,39,45,46,50,55,56,58,64,66,[68][69][70][71][72][73]81,82 . NBF was significantly higher in AB compared to AP alone (WMD = À10.66%, 95% CI À 16.38% to À4.94%) and XG alone (WMD = À7.93%, 95% CI À 15.11% to À0.75%).…”

Polysaccharide-Based Systems for Targeted Stem Cell Differentiation and Bone Regeneration

“…Although clinical studies on novel materials are rare, one uses a hyaluronic acid-based bone graft for sinus augmentation. The study compares the material to commonly used collagenated heterologous bone and finds enhanced bone formation after 4 months [84]. Additional to their use in bone tissue regeneration, systems with hyaluronic acid could also play a role as release systems for drugs or growth factors.…”

Maxillary Sinus Lifting

“…Dogan et al 55 performed a comparison using micro-CT and histomorphometry on the early recovery period of collagenized heterolog bone graft (test group)alone and mixed with hyaluronic acid and collagenized heterolog bone graft (control group). Thirteen systemically healthy patients underwent bilateral sinus augmentation and one side was filled with collagenized heterolog bone graft alone while the other side was filled with hyaluronic acid + collagenized heterolog bone graft.…”