Evaluation of HPMPC therapy for primary and recurrent genital herpes in mice and guinea pigs

RCMV ALL-03 Model and Study of CMV Pathogenesis in Congenital Infection

“…In other related studies, the toxicity of antiviral compounds which cannot be reflected by in vitro studies was evaluated using GPCMV. In vivo study with CDV was done with this model and it showed renal toxicity in the tested group (Bravo et al, 1993;Li et al, 1990), which was similar to that observed in humans.…”

Preclinical Toxicology of Vaccines

“…Because genital disease in guinea pigs closely resembles that of humans [162], it has been used to test potential vaccines [163,164] and antiviral chemotherapies [165] for genital herpes. McClements et al [166] reported that immunization with DNA encoding herpes simplex virus type 2 full length glycoprotein D (HSV-2 gD) or a truncated form of HSV-2 gB induced immune responses in mice and protected them from lethal challenge with HSV-2.…”

Preclinical Toxicology of Vaccines 1 1Disclaimer: The findings and conclusions in this chapter have not been formally disseminated by the Food and Drug Administration and should not be construed to represent any Agency determination or policy.

“…Because genital disease in guinea pigs closely resembles that of humans [162], it has been used to test potential vaccines [163,164] and antiviral chemotherapies [165] for genital herpes. McClements et al [166] reported that immunization with DNA-encoding herpes simplex virus type 2 full length glycoprotein D (HSV-2 gD) or a truncated form of HSV-2 g-induced immune responses in mice and protected them from lethal challenge with HSV-2.…”