Evaluation of Host Tissue Integration, Revascularization, and Cellular Infiltration Within Various Dermal Substrates

Capito, Anthony E.; Tholpady, Sunil S.; Agrawal, Hitesh; Drake, David B.; Katz, Adam J.

doi:10.1097/sap.0b013e31823b6b01

Cited by 62 publications

(57 citation statements)

References 25 publications

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“…[240][241][242][243][244][245] As with the aforementioned ECM products, the dermal matrices serve as scaffolds for cellular repopulation and angiogenesis, with varying degrees of incorporation into the recipient wound bed. 246,247 One of these cryopreserved dermal allografts, referred to as a human skin allograft, claims that both the extracellular and cellular components are preserved during the minimal processing. 242,243 Two of the available dermal regenerative matrices have successfully undergone small RCTs (Graftjacket Ò ; KCI, San Antonio, TX and TheraSkin Ò ; Soluble Systems, Newport News, VA), while a third is currently undergoing a clinical trial for DFUs (dCell Ò ; Tissue Regenix, San Antonio, TX).…”

Section: Biological and Bioengineered Therapiesmentioning

confidence: 99%

Challenges in the Treatment of Chronic Wounds

Frykberg

Banks

2015

Advances in Wound Care

1,595

1,429

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Significance: Chronic wounds include, but are not limited, to diabetic foot ulcers, venous leg ulcers, and pressure ulcers. They are a challenge to wound care professionals and consume a great deal of healthcare resources around the globe. This review discusses the pathophysiology of complex chronic wounds and the means and modalities currently available to achieve healing in such patients.Recent Advances: Although often difficult to treat, an understanding of the underlying pathophysiology and specific attention toward managing these perturbations can often lead to successful healing.Critical Issues: Overcoming the factors that contribute to delayed healing are key components of a comprehensive approach to wound care and present the primary challenges to the treatment of chronic wounds. When wounds fail to achieve sufficient healing after 4 weeks of standard care, reassessment of underlying pathology and consideration of the need for advanced therapeutic agents should be undertaken. However, selection of an appropriate therapy is often not evidence based.Future Directions: Basic tenets of care need to be routinely followed, and a systematic evaluation of patients and their wounds will also facilitate appropriate care. Underlying pathologies, which result in the failure of these wounds to heal, differ among various types of chronic wounds. A better understanding of the differences between various types of chronic wounds at the molecular and cellular levels should improve our treatment approaches, leading to better healing rates, and facilitate the development of new more effective therapies. More evidence for the efficacy of current and future advanced wound therapies is required for their appropriate use.

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Section: Biological and Bioengineered Therapiesmentioning

confidence: 99%

Challenges in the Treatment of Chronic Wounds

Frykberg

Banks

2015

Advances in Wound Care

1,595

1,429

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“…Finally, the immune/inflammatory response of rats may not accurately reflect that of humans-especially in response to human-derived tissues. Despite these challenges and limitations, recent work in our lab [25] takes the field a step closer to elucidating quantifiable differences in host response to different matrices on a cellular level, and provides an objective foundation upon which to gather, compare and associate clinical use and outcomes.…”

Section: Discussionmentioning

confidence: 99%

Macrophage phenotypes correspond with remodeling outcomes of various acellular dermal matrices

Agrawal¹,

Tholpady²,

Capito³

et al. 2012

OJRM

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“…9,10 This ADM is decellularized, but it maintains multiple growth factors and tissue substances that support rapid host integration to become syngeneic. 10 It is stored at room temperature and is ready to use without rehydration. 9 This ADM has been shown to decrease scar formation when used after scar excision.…”

mentioning

confidence: 99%